Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population

Jyotsna Batra; Sudipta Das; Rajshekhar Chatterjee; Sunandini Chandra; Balaram Ghosh

doi:10.1016/j.jaci.2011.01.044

Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population

Jyotsna Batra^*
, Sudipta Das
, Rajshekhar Chatterjee
, Sunandini Chandra
, Balaram Ghosh

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Research › peer-review

Abstract

Monocyte chemotactic protein (MCP3) 3 interacts with several CC chemokine receptors expressed on various leukocyte subpopulations, thus activating crucial effector cells involved in asthma pathogenesis. MCP3 mRNA expression was found to be significantly increased in the bronchial mucosa of atopic and nonatopic asthmatic subjects. Additionally, MCP3 levels were significantly increased in bronchoalveolar lavage fluid of asthmatic subjects and associated with increased accumulation of bronchial mucosal eosinophils.

Original language	English
Pages (from-to)	239-242.e3
Number of pages	4
Journal	Journal of Allergy and Clinical Immunology
Volume	128
Issue number	1
DOIs	https://doi.org/10.1016/j.jaci.2011.01.044
Publication status	Published - Jul 2011
Externally published	Yes

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10.1016/j.jaci.2011.01.044

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title = "Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population",

abstract = "Monocyte chemotactic protein (MCP3) 3 interacts with several CC chemokine receptors expressed on various leukocyte subpopulations, thus activating crucial effector cells involved in asthma pathogenesis. MCP3 mRNA expression was found to be significantly increased in the bronchial mucosa of atopic and nonatopic asthmatic subjects. Additionally, MCP3 levels were significantly increased in bronchoalveolar lavage fluid of asthmatic subjects and associated with increased accumulation of bronchial mucosal eosinophils.",

author = "Jyotsna Batra and Sudipta Das and Rajshekhar Chatterjee and Sunandini Chandra and Balaram Ghosh",

year = "2011",

month = jul,

doi = "10.1016/j.jaci.2011.01.044",

language = "English",

volume = "128",

pages = "239--242.e3",

journal = "Journal of Allergy and Clinical Immunology",

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T1 - Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population

AU - Batra, Jyotsna

AU - Das, Sudipta

AU - Chatterjee, Rajshekhar

AU - Chandra, Sunandini

AU - Ghosh, Balaram

PY - 2011/7

Y1 - 2011/7

N2 - Monocyte chemotactic protein (MCP3) 3 interacts with several CC chemokine receptors expressed on various leukocyte subpopulations, thus activating crucial effector cells involved in asthma pathogenesis. MCP3 mRNA expression was found to be significantly increased in the bronchial mucosa of atopic and nonatopic asthmatic subjects. Additionally, MCP3 levels were significantly increased in bronchoalveolar lavage fluid of asthmatic subjects and associated with increased accumulation of bronchial mucosal eosinophils.

AB - Monocyte chemotactic protein (MCP3) 3 interacts with several CC chemokine receptors expressed on various leukocyte subpopulations, thus activating crucial effector cells involved in asthma pathogenesis. MCP3 mRNA expression was found to be significantly increased in the bronchial mucosa of atopic and nonatopic asthmatic subjects. Additionally, MCP3 levels were significantly increased in bronchoalveolar lavage fluid of asthmatic subjects and associated with increased accumulation of bronchial mucosal eosinophils.

UR - https://www.scopus.com/pages/publications/79959814453

U2 - 10.1016/j.jaci.2011.01.044

DO - 10.1016/j.jaci.2011.01.044

M3 - Letter

AN - SCOPUS:79959814453

SN - 0091-6749

VL - 128

SP - 239-242.e3

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 1

ER -

Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population

Abstract

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