Molecular mechanisms underlying the effects of statins in the central nervous system

Amelia J. McFarland, Shailendra Anoopkumar-Dukie, Devinder S. Arora, Gary D. Grant, Catherine M. McDermott, Anthony V. Perkins, Andrew K. Davey*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

63 Citations (Scopus)

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary and secondary prevention against cardiovascular disease and stroke. Statins’ effects on the central nervous system (CNS), particularly on cognition and neurological disorders such as stroke and multiple sclerosis, have received increasing attention in recent years, both within the scientific community and in the media. Current understanding of statins’ effects is limited by a lack of mechanism-based studies, as well as the assumption that all statins have the same pharmacological effect in the central nervous system. This review aims to provide an updated discussion on the molecular mechanisms contributing to statins’ possible effects on cognitive function, neurodegenerative disease, and various neurological disorders such as stroke, epilepsy, depression and CNS cancers. Additionally, the pharmacokinetic differences between statins and how these may result in statin-specific neurological effects are also discussed.

Original languageEnglish
Pages (from-to)20607-20637
Number of pages31
JournalInternational Journal of Molecular Sciences
Volume15
Issue number11
DOIs
Publication statusPublished - 10 Sep 2014

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McFarland, A. J., Anoopkumar-Dukie, S., Arora, D. S., Grant, G. D., McDermott, C. M., Perkins, A. V., & Davey, A. K. (2014). Molecular mechanisms underlying the effects of statins in the central nervous system. International Journal of Molecular Sciences, 15(11), 20607-20637. https://doi.org/10.3390/ijms151120607