Mediterranean-type diets and inflammatory markers in patients with coronary heart disease: a systematic review and meta-analysis

Hannah L. Mayr, Audrey C. Tierney, Colleen J. Thomas, Miguel Ruiz-Canela, Jessica Radcliffe, Catherine Itsiopoulos

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
9 Downloads (Pure)

Abstract

The health benefits of a Mediterranean diet are thought to be mediated via its anti-inflammatory effects; however, the anti-inflammatory effect of this diet is unclear in patients who have already developed coronary heart disease (CHD). This systematic review and meta-analysis assessed the effect of Mediterranean-type diets on cytokines and adipokines in patients with CHD. An electronic search of the literature was conducted up to October 2016 using PubMed, Scopus, Web of Science, and Cochrane Library. Eleven of the 435 articles identified met eligibility criteria. Four observational studies reported significant inverse associations between Mediterranean-type diet scores and inflammatory cytokines. Five clinical trials (4 in non-Mediterranean countries) demonstrated nonsignificant reductions, and 2 trials conducted in Spain demonstrated significant reductions in C-reactive protein with a Mediterranean-type diet. Random effects meta-analysis of 4 controlled trials detected a nonsignificant difference in final mean value of C-reactive protein with Mediterranean-type diet vs low-fat diet. Despite promising findings from observational studies, this review demonstrated mostly nonsignificant effects of Mediterranean-type diet interventions on inflammatory cytokines and no effect in comparison to low-fat diets in controlled trials conducted primarily in Mediterranean populations. Therefore, randomized controlled trials of a traditional Mediterranean diet in non-Mediterranean populations and with multiple inflammatory biomarkers are needed in the high-risk CHD patient group.

Original languageEnglish
Pages (from-to)10-24
Number of pages15
JournalNutrition Research
Volume50
Early online date21 Oct 2017
DOIs
Publication statusPublished - 1 Feb 2018
Externally publishedYes

Fingerprint

Mediterranean Diet
systematic review
Nutrition
meta-analysis
Coronary Disease
Meta-Analysis
diet
Mediterranean diet
cytokines
low fat diet
C-reactive protein
observational studies
Fat-Restricted Diet
anti-inflammatory activity
Cytokines
C-Reactive Protein
Observational Studies
Anti-Inflammatory Agents
adipokines
Library Science

Cite this

Mayr, Hannah L. ; Tierney, Audrey C. ; Thomas, Colleen J. ; Ruiz-Canela, Miguel ; Radcliffe, Jessica ; Itsiopoulos, Catherine. / Mediterranean-type diets and inflammatory markers in patients with coronary heart disease : a systematic review and meta-analysis. In: Nutrition Research. 2018 ; Vol. 50. pp. 10-24.
@article{8a5c24d983b346cab18516765e9d761d,
title = "Mediterranean-type diets and inflammatory markers in patients with coronary heart disease: a systematic review and meta-analysis",
abstract = "The health benefits of a Mediterranean diet are thought to be mediated via its anti-inflammatory effects; however, the anti-inflammatory effect of this diet is unclear in patients who have already developed coronary heart disease (CHD). This systematic review and meta-analysis assessed the effect of Mediterranean-type diets on cytokines and adipokines in patients with CHD. An electronic search of the literature was conducted up to October 2016 using PubMed, Scopus, Web of Science, and Cochrane Library. Eleven of the 435 articles identified met eligibility criteria. Four observational studies reported significant inverse associations between Mediterranean-type diet scores and inflammatory cytokines. Five clinical trials (4 in non-Mediterranean countries) demonstrated nonsignificant reductions, and 2 trials conducted in Spain demonstrated significant reductions in C-reactive protein with a Mediterranean-type diet. Random effects meta-analysis of 4 controlled trials detected a nonsignificant difference in final mean value of C-reactive protein with Mediterranean-type diet vs low-fat diet. Despite promising findings from observational studies, this review demonstrated mostly nonsignificant effects of Mediterranean-type diet interventions on inflammatory cytokines and no effect in comparison to low-fat diets in controlled trials conducted primarily in Mediterranean populations. Therefore, randomized controlled trials of a traditional Mediterranean diet in non-Mediterranean populations and with multiple inflammatory biomarkers are needed in the high-risk CHD patient group.",
author = "Mayr, {Hannah L.} and Tierney, {Audrey C.} and Thomas, {Colleen J.} and Miguel Ruiz-Canela and Jessica Radcliffe and Catherine Itsiopoulos",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.nutres.2017.10.014",
language = "English",
volume = "50",
pages = "10--24",
journal = "Progress in Food and Nutrition Science",
issn = "0271-5317",
publisher = "Elsevier",

}

Mediterranean-type diets and inflammatory markers in patients with coronary heart disease : a systematic review and meta-analysis. / Mayr, Hannah L.; Tierney, Audrey C.; Thomas, Colleen J.; Ruiz-Canela, Miguel; Radcliffe, Jessica; Itsiopoulos, Catherine.

In: Nutrition Research, Vol. 50, 01.02.2018, p. 10-24.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Mediterranean-type diets and inflammatory markers in patients with coronary heart disease

T2 - a systematic review and meta-analysis

AU - Mayr, Hannah L.

AU - Tierney, Audrey C.

AU - Thomas, Colleen J.

AU - Ruiz-Canela, Miguel

AU - Radcliffe, Jessica

AU - Itsiopoulos, Catherine

PY - 2018/2/1

Y1 - 2018/2/1

N2 - The health benefits of a Mediterranean diet are thought to be mediated via its anti-inflammatory effects; however, the anti-inflammatory effect of this diet is unclear in patients who have already developed coronary heart disease (CHD). This systematic review and meta-analysis assessed the effect of Mediterranean-type diets on cytokines and adipokines in patients with CHD. An electronic search of the literature was conducted up to October 2016 using PubMed, Scopus, Web of Science, and Cochrane Library. Eleven of the 435 articles identified met eligibility criteria. Four observational studies reported significant inverse associations between Mediterranean-type diet scores and inflammatory cytokines. Five clinical trials (4 in non-Mediterranean countries) demonstrated nonsignificant reductions, and 2 trials conducted in Spain demonstrated significant reductions in C-reactive protein with a Mediterranean-type diet. Random effects meta-analysis of 4 controlled trials detected a nonsignificant difference in final mean value of C-reactive protein with Mediterranean-type diet vs low-fat diet. Despite promising findings from observational studies, this review demonstrated mostly nonsignificant effects of Mediterranean-type diet interventions on inflammatory cytokines and no effect in comparison to low-fat diets in controlled trials conducted primarily in Mediterranean populations. Therefore, randomized controlled trials of a traditional Mediterranean diet in non-Mediterranean populations and with multiple inflammatory biomarkers are needed in the high-risk CHD patient group.

AB - The health benefits of a Mediterranean diet are thought to be mediated via its anti-inflammatory effects; however, the anti-inflammatory effect of this diet is unclear in patients who have already developed coronary heart disease (CHD). This systematic review and meta-analysis assessed the effect of Mediterranean-type diets on cytokines and adipokines in patients with CHD. An electronic search of the literature was conducted up to October 2016 using PubMed, Scopus, Web of Science, and Cochrane Library. Eleven of the 435 articles identified met eligibility criteria. Four observational studies reported significant inverse associations between Mediterranean-type diet scores and inflammatory cytokines. Five clinical trials (4 in non-Mediterranean countries) demonstrated nonsignificant reductions, and 2 trials conducted in Spain demonstrated significant reductions in C-reactive protein with a Mediterranean-type diet. Random effects meta-analysis of 4 controlled trials detected a nonsignificant difference in final mean value of C-reactive protein with Mediterranean-type diet vs low-fat diet. Despite promising findings from observational studies, this review demonstrated mostly nonsignificant effects of Mediterranean-type diet interventions on inflammatory cytokines and no effect in comparison to low-fat diets in controlled trials conducted primarily in Mediterranean populations. Therefore, randomized controlled trials of a traditional Mediterranean diet in non-Mediterranean populations and with multiple inflammatory biomarkers are needed in the high-risk CHD patient group.

UR - http://www.scopus.com/inward/record.url?scp=85038408317&partnerID=8YFLogxK

U2 - 10.1016/j.nutres.2017.10.014

DO - 10.1016/j.nutres.2017.10.014

M3 - Article

VL - 50

SP - 10

EP - 24

JO - Progress in Food and Nutrition Science

JF - Progress in Food and Nutrition Science

SN - 0271-5317

ER -