Medication adherence in older patients with dementia: A systematic literature review

Najwan El-Saifi, Wendy Moyle, Cindy Jones, Haitham Tuffaha

Research output: Contribution to journalReview articleResearchpeer-review

7 Citations (Scopus)

Abstract

Background: Older patients with dementia are often unable to take their medications as prescribed due to cognitive and physical impairment. Objectives: To review the evidence on medication adherence in older patients with dementia in terms of the level of adherence, outcomes, contributing factors, and available interventions. Methods: A systematic literature review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searched databases included CINAHL, Cochrane Library, DARE, MEDLINE, and PubMed. Results: Eighteen studies reported levels of medication adherence or discontinuation and related factors. Medication adherence ranged from 17% to 42%, and medication discontinuation before the end of treatment ranged from 37% to 80%. Nonadherence was associated with an increased risk of hospitalization or death, while increasing age, choice of medication, use of concomitant medications, and medicines’ costs were reported to decrease medication adherence. Telehealth home monitoring and treatment modification were the only interventions reported in the literature to improve medication adherence in this population. Conclusion: Older patients with dementia have a low level of medication adherence. Future research should focus on the development and implementation of interventions to help older patients with dementia and their caregivers make better use of medications.

Original languageEnglish
Pages (from-to)322-334
Number of pages13
JournalJournal of Pharmacy Practice
Volume31
Issue number3
DOIs
Publication statusPublished - 1 Jun 2018
Externally publishedYes

Fingerprint

Medication Adherence
Dementia
Telemedicine
PubMed
MEDLINE
Caregivers
Libraries
Meta-Analysis
Hospitalization
Databases
Guidelines
Costs and Cost Analysis
Therapeutics
Population

Cite this

El-Saifi, Najwan ; Moyle, Wendy ; Jones, Cindy ; Tuffaha, Haitham. / Medication adherence in older patients with dementia : A systematic literature review. In: Journal of Pharmacy Practice. 2018 ; Vol. 31, No. 3. pp. 322-334.
@article{5f79924555ea4d388403d0dfd71dc69f,
title = "Medication adherence in older patients with dementia: A systematic literature review",
abstract = "Background: Older patients with dementia are often unable to take their medications as prescribed due to cognitive and physical impairment. Objectives: To review the evidence on medication adherence in older patients with dementia in terms of the level of adherence, outcomes, contributing factors, and available interventions. Methods: A systematic literature review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searched databases included CINAHL, Cochrane Library, DARE, MEDLINE, and PubMed. Results: Eighteen studies reported levels of medication adherence or discontinuation and related factors. Medication adherence ranged from 17{\%} to 42{\%}, and medication discontinuation before the end of treatment ranged from 37{\%} to 80{\%}. Nonadherence was associated with an increased risk of hospitalization or death, while increasing age, choice of medication, use of concomitant medications, and medicines’ costs were reported to decrease medication adherence. Telehealth home monitoring and treatment modification were the only interventions reported in the literature to improve medication adherence in this population. Conclusion: Older patients with dementia have a low level of medication adherence. Future research should focus on the development and implementation of interventions to help older patients with dementia and their caregivers make better use of medications.",
author = "Najwan El-Saifi and Wendy Moyle and Cindy Jones and Haitham Tuffaha",
year = "2018",
month = "6",
day = "1",
doi = "10.1177/0897190017710524",
language = "English",
volume = "31",
pages = "322--334",
journal = "Journal of Pharmacy Practice",
issn = "0897-1900",
publisher = "SAGE Publications Ltd",
number = "3",

}

Medication adherence in older patients with dementia : A systematic literature review. / El-Saifi, Najwan; Moyle, Wendy; Jones, Cindy; Tuffaha, Haitham.

In: Journal of Pharmacy Practice, Vol. 31, No. 3, 01.06.2018, p. 322-334.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Medication adherence in older patients with dementia

T2 - A systematic literature review

AU - El-Saifi, Najwan

AU - Moyle, Wendy

AU - Jones, Cindy

AU - Tuffaha, Haitham

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Background: Older patients with dementia are often unable to take their medications as prescribed due to cognitive and physical impairment. Objectives: To review the evidence on medication adherence in older patients with dementia in terms of the level of adherence, outcomes, contributing factors, and available interventions. Methods: A systematic literature review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searched databases included CINAHL, Cochrane Library, DARE, MEDLINE, and PubMed. Results: Eighteen studies reported levels of medication adherence or discontinuation and related factors. Medication adherence ranged from 17% to 42%, and medication discontinuation before the end of treatment ranged from 37% to 80%. Nonadherence was associated with an increased risk of hospitalization or death, while increasing age, choice of medication, use of concomitant medications, and medicines’ costs were reported to decrease medication adherence. Telehealth home monitoring and treatment modification were the only interventions reported in the literature to improve medication adherence in this population. Conclusion: Older patients with dementia have a low level of medication adherence. Future research should focus on the development and implementation of interventions to help older patients with dementia and their caregivers make better use of medications.

AB - Background: Older patients with dementia are often unable to take their medications as prescribed due to cognitive and physical impairment. Objectives: To review the evidence on medication adherence in older patients with dementia in terms of the level of adherence, outcomes, contributing factors, and available interventions. Methods: A systematic literature review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searched databases included CINAHL, Cochrane Library, DARE, MEDLINE, and PubMed. Results: Eighteen studies reported levels of medication adherence or discontinuation and related factors. Medication adherence ranged from 17% to 42%, and medication discontinuation before the end of treatment ranged from 37% to 80%. Nonadherence was associated with an increased risk of hospitalization or death, while increasing age, choice of medication, use of concomitant medications, and medicines’ costs were reported to decrease medication adherence. Telehealth home monitoring and treatment modification were the only interventions reported in the literature to improve medication adherence in this population. Conclusion: Older patients with dementia have a low level of medication adherence. Future research should focus on the development and implementation of interventions to help older patients with dementia and their caregivers make better use of medications.

UR - http://www.scopus.com/inward/record.url?scp=85041350479&partnerID=8YFLogxK

U2 - 10.1177/0897190017710524

DO - 10.1177/0897190017710524

M3 - Review article

VL - 31

SP - 322

EP - 334

JO - Journal of Pharmacy Practice

JF - Journal of Pharmacy Practice

SN - 0897-1900

IS - 3

ER -