MDR/XDR-TB Management of Patients and Contacts: Challenges Facing the New Decade. The 2020 Clinical Update by the Global Tuberculosis Network

Global Tuberculosis Network; Giovanni Battista Migliori; Simon Tiberi; Alimuddin Zumla; Eskild Petersen; Jeremiah Muhwa Chakaya; Christian Wejse; Marcela Muñoz Torrico; Raquel Duarte; Jan Willem Alffenaar; H. Simon Schaaf; Ben J. Marais; Daniela Maria Cirillo; Riccardo Alagna; Adrian Rendon; Emanuele Pontali; Alberto Piubello; José Figueroa; Gabriella Ferlazzo; Alberto García-Basteiro; Rosella Centis; Dina Visca; Lia D'Ambrosio; Giovanni Sotgiu

doi:10.1016/j.ijid.2020.01.042

MDR/XDR-TB Management of Patients and Contacts: Challenges Facing the New Decade. The 2020 Clinical Update by the Global Tuberculosis Network

Global Tuberculosis Network, Giovanni Battista Migliori^*, Simon Tiberi, Alimuddin Zumla, Eskild Petersen, Jeremiah Muhwa Chakaya, Christian Wejse, Marcela Muñoz Torrico, Raquel Duarte, Jan Willem Alffenaar, H. Simon Schaaf, Ben J. Marais, Daniela Maria Cirillo, Riccardo Alagna, Adrian Rendon, Emanuele Pontali, Alberto Piubello, José Figueroa, Gabriella Ferlazzo, Alberto García-BasteiroRosella Centis, Dina Visca, Lia D'Ambrosio, Giovanni Sotgiu

^*Corresponding author for this work

Institute for Evidence-Based Healthcare

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Abstract

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.

Original language	English
Pages (from-to)	S15-S25
Number of pages	11
Journal	International Journal of Infectious Diseases
Volume	92
Early online date	4 Feb 2020
DOIs	https://doi.org/10.1016/j.ijid.2020.01.042
Publication status	Published - Mar 2020

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MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis NetworkFinal published version, 1.33 MBLicence: CC BY-NC-ND

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Global Tuberculosis Network, Migliori, G. B., Tiberi, S., Zumla, A., Petersen, E., Chakaya, J. M., Wejse, C., Muñoz Torrico, M., Duarte, R., Alffenaar, J. W., Schaaf, H. S., Marais, B. J., Cirillo, D. M., Alagna, R., Rendon, A., Pontali, E., Piubello, A., Figueroa, J., Ferlazzo, G., ... Sotgiu, G. (2020). MDR/XDR-TB Management of Patients and Contacts: Challenges Facing the New Decade. The 2020 Clinical Update by the Global Tuberculosis Network. International Journal of Infectious Diseases, 92, S15-S25. https://doi.org/10.1016/j.ijid.2020.01.042

@article{36a41fce2efd4265ac3801abaf561912,

title = "MDR/XDR-TB Management of Patients and Contacts: Challenges Facing the New Decade. The 2020 Clinical Update by the Global Tuberculosis Network",

abstract = "The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.",

author = "{Global Tuberculosis Network} and Migliori, {Giovanni Battista} and Simon Tiberi and Alimuddin Zumla and Eskild Petersen and Chakaya, {Jeremiah Muhwa} and Christian Wejse and {Mu{\~n}oz Torrico}, Marcela and Raquel Duarte and Alffenaar, {Jan Willem} and Schaaf, {H. Simon} and Marais, {Ben J.} and Cirillo, {Daniela Maria} and Riccardo Alagna and Adrian Rendon and Emanuele Pontali and Alberto Piubello and Jos{\'e} Figueroa and Gabriella Ferlazzo and Alberto Garc{\'i}a-Basteiro and Rosella Centis and Dina Visca and Lia D'Ambrosio and Giovanni Sotgiu and Arkub, {T. Abu} and Akkerman, {O. W.} and A. Aleksa and E. Belilovski and E. Bernal and Blanc, {F. X.} and M. Boeree and S. Borisov and J. Bruchfeld and {Cadi{\~n}anos Loidi}, J. and Caminero, {J. A.} and Carvalho, {A. C.} and {Cebrian Gallardo}, {J. J.} and Charalampos and E. Danila and {Davies Forsman}, L. and J. Denholm and K. Dheda and R. Diel and S. Diktanas and C. Dobler and M. Enwerem and S. Esposito and {Escobar Salinas}, N. and A. Filippov and B. Formenti and {Garc{\'i}a Garc{\'i}a}, {J. M.} and D. Goletti and {Gomez Rosso}, R. and G. Gualano and P. Isaakidis and A. Kaluzhenina and S. Koirala and L. Kuksa and H. Kunst and Y. Li and C. Magis-Escurra and V. Manfrin and S. Manga and K. Manika and V. Marchese and {Mart{\'i}nez Robles}, E. and A. Maryandyshev and A. Matteelli and A. Mariani and J. Mazza-Stalder and F. Mello and L. Mendoza and A. Mesi and S. Miliauskas and {Mustafa Hamdan}, H. and N. Ndjeka and {Nieto Marcos}, M. and Ottenhoff, {T. H.M.} and Palmero, {D. J.} and F. Palmieri and A. Papavasileiou and Payen, {M. C.} and A. Pontarelli and {Pretti Dalcolmo}, M. and {Quir{\'o}s Fernandez}, S. and R. Romero and {Rossato Silva}, D. and Santos, {A. P.} and B. Seaworth and M. Sinitsyn and A. Skrahina and I. Solovic and A. Spanevello and M. Tadolini and C. Torres and Z. Udwadia and {van den Boom}, M. and Volchenkov, {G. V.} and A. Yedilbayev and R. Zaleskis and Zellweger, {J. P.}",

year = "2020",

month = mar,

doi = "10.1016/j.ijid.2020.01.042",

language = "English",

volume = "92",

pages = "S15--S25",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier",

}

Global Tuberculosis Network, Migliori, GB, Tiberi, S, Zumla, A, Petersen, E, Chakaya, JM, Wejse, C, Muñoz Torrico, M, Duarte, R, Alffenaar, JW, Schaaf, HS, Marais, BJ, Cirillo, DM, Alagna, R, Rendon, A, Pontali, E, Piubello, A, Figueroa, J, Ferlazzo, G, García-Basteiro, A, Centis, R, Visca, D, D'Ambrosio, L & Sotgiu, G 2020, 'MDR/XDR-TB Management of Patients and Contacts: Challenges Facing the New Decade. The 2020 Clinical Update by the Global Tuberculosis Network', International Journal of Infectious Diseases, vol. 92, pp. S15-S25. https://doi.org/10.1016/j.ijid.2020.01.042

MDR/XDR-TB Management of Patients and Contacts: Challenges Facing the New Decade. The 2020 Clinical Update by the Global Tuberculosis Network. / Global Tuberculosis Network; Migliori, Giovanni Battista; Tiberi, Simon et al.
In: International Journal of Infectious Diseases, Vol. 92, 03.2020, p. S15-S25.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - MDR/XDR-TB Management of Patients and Contacts: Challenges Facing the New Decade. The 2020 Clinical Update by the Global Tuberculosis Network

AU - Global Tuberculosis Network

AU - Migliori, Giovanni Battista

AU - Tiberi, Simon

AU - Zumla, Alimuddin

AU - Petersen, Eskild

AU - Chakaya, Jeremiah Muhwa

AU - Wejse, Christian

AU - Muñoz Torrico, Marcela

AU - Duarte, Raquel

AU - Alffenaar, Jan Willem

AU - Schaaf, H. Simon

AU - Marais, Ben J.

AU - Cirillo, Daniela Maria

AU - Alagna, Riccardo

AU - Rendon, Adrian

AU - Pontali, Emanuele

AU - Piubello, Alberto

AU - Figueroa, José

AU - Ferlazzo, Gabriella

AU - García-Basteiro, Alberto

AU - Centis, Rosella

AU - Visca, Dina

AU - D'Ambrosio, Lia

AU - Sotgiu, Giovanni

AU - Arkub, T. Abu

AU - Akkerman, O. W.

AU - Aleksa, A.

AU - Belilovski, E.

AU - Bernal, E.

AU - Blanc, F. X.

AU - Boeree, M.

AU - Borisov, S.

AU - Bruchfeld, J.

AU - Cadiñanos Loidi, J.

AU - Caminero, J. A.

AU - Carvalho, A. C.

AU - Cebrian Gallardo, J. J.

AU - Charalampos,

AU - Danila, E.

AU - Davies Forsman, L.

AU - Denholm, J.

AU - Dheda, K.

AU - Diel, R.

AU - Diktanas, S.

AU - Dobler, C.

AU - Enwerem, M.

AU - Esposito, S.

AU - Escobar Salinas, N.

AU - Filippov, A.

AU - Formenti, B.

AU - García García, J. M.

AU - Goletti, D.

AU - Gomez Rosso, R.

AU - Gualano, G.

AU - Isaakidis, P.

AU - Kaluzhenina, A.

AU - Koirala, S.

AU - Kuksa, L.

AU - Kunst, H.

AU - Li, Y.

AU - Magis-Escurra, C.

AU - Manfrin, V.

AU - Manga, S.

AU - Manika, K.

AU - Marchese, V.

AU - Martínez Robles, E.

AU - Maryandyshev, A.

AU - Matteelli, A.

AU - Mariani, A.

AU - Mazza-Stalder, J.

AU - Mello, F.

AU - Mendoza, L.

AU - Mesi, A.

AU - Miliauskas, S.

AU - Mustafa Hamdan, H.

AU - Ndjeka, N.

AU - Nieto Marcos, M.

AU - Ottenhoff, T. H.M.

AU - Palmero, D. J.

AU - Palmieri, F.

AU - Papavasileiou, A.

AU - Payen, M. C.

AU - Pontarelli, A.

AU - Pretti Dalcolmo, M.

AU - Quirós Fernandez, S.

AU - Romero, R.

AU - Rossato Silva, D.

AU - Santos, A. P.

AU - Seaworth, B.

AU - Sinitsyn, M.

AU - Skrahina, A.

AU - Solovic, I.

AU - Spanevello, A.

AU - Tadolini, M.

AU - Torres, C.

AU - Udwadia, Z.

AU - van den Boom, M.

AU - Volchenkov, G. V.

AU - Yedilbayev, A.

AU - Zaleskis, R.

AU - Zellweger, J. P.

PY - 2020/3

Y1 - 2020/3

N2 - The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.

AB - The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.

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U2 - 10.1016/j.ijid.2020.01.042

DO - 10.1016/j.ijid.2020.01.042

M3 - Article

C2 - 32032752

AN - SCOPUS:85079627781

SN - 1201-9712

VL - 92

SP - S15-S25

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

MDR/XDR-TB Management of Patients and Contacts: Challenges Facing the New Decade. The 2020 Clinical Update by the Global Tuberculosis Network

Abstract

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