Lymphocyte recirculation: the need for site-specific receptors to dictate T-lymphocyte localization into different tissue sites

F J Frogner, H C O'Neill

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

This paper addresses the need for receptors involved in recirculation of T lymphocytes both during development and during an immune response or inflammation. Some known receptors present on T lymphocytes which are important in maintaining normal T-cell localization and function, i.e. the integrins, LECAMs, LPAM-1 and H-CAM (CD44) are considered in terms of the specificity which they confer on lymphocyte recirculation. A clear understanding of lymphocyte trafficking patterns and of the receptors involved may provide, for example, novel therapies for treatment of malignant cancer, alleviation of damage caused by lymphocytes during inflammatory responses, and targeting of cells to sites of infection.

Original languageEnglish
Pages (from-to)627-632
Number of pages6
JournalScandinavian Journal of Immunology
Volume35
Issue number6
DOIs
Publication statusPublished - Jun 1992
Externally publishedYes

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Lymphocytes
T-Lymphocytes
L-Selectin
Integrins
Inflammation
Infection
Neoplasms
Therapeutics

Cite this

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abstract = "This paper addresses the need for receptors involved in recirculation of T lymphocytes both during development and during an immune response or inflammation. Some known receptors present on T lymphocytes which are important in maintaining normal T-cell localization and function, i.e. the integrins, LECAMs, LPAM-1 and H-CAM (CD44) are considered in terms of the specificity which they confer on lymphocyte recirculation. A clear understanding of lymphocyte trafficking patterns and of the receptors involved may provide, for example, novel therapies for treatment of malignant cancer, alleviation of damage caused by lymphocytes during inflammatory responses, and targeting of cells to sites of infection.",
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Lymphocyte recirculation : the need for site-specific receptors to dictate T-lymphocyte localization into different tissue sites. / Frogner, F J; O'Neill, H C.

In: Scandinavian Journal of Immunology, Vol. 35, No. 6, 06.1992, p. 627-632.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Lymphocyte recirculation

T2 - the need for site-specific receptors to dictate T-lymphocyte localization into different tissue sites

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AU - O'Neill, H C

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AB - This paper addresses the need for receptors involved in recirculation of T lymphocytes both during development and during an immune response or inflammation. Some known receptors present on T lymphocytes which are important in maintaining normal T-cell localization and function, i.e. the integrins, LECAMs, LPAM-1 and H-CAM (CD44) are considered in terms of the specificity which they confer on lymphocyte recirculation. A clear understanding of lymphocyte trafficking patterns and of the receptors involved may provide, for example, novel therapies for treatment of malignant cancer, alleviation of damage caused by lymphocytes during inflammatory responses, and targeting of cells to sites of infection.

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DO - 10.1111/j.1365-3083.1992.tb02967.x

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