Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis

Irving L Weissman; M S McGrath; R A Reichert; W M Gallatin; Sophie Ezine; P Fink; Eugene C Butcher; J Marian; H C O'Neill

doi:10.1007/978-3-642-70385-0_93

Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis

Irving L Weissman, M S McGrath, R A Reichert, W M Gallatin, Sophie Ezine, P Fink, Eugene C Butcher, J Marian, H C O'Neill

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The thymus is believed to be the major, if not the sole site of differentiation of T lymphocytes [1, 2]. During fetal development the thymus receives a bolus of precursors of T cells from the hematopoietic organs, probably the fetal liver and/or the yolk sac [3, 4]; these populations subsequently undergo self-renewal as well as maturation [5]. In adult life the thymus receives cells from the bone marrow at a very low level, but in times of stress, or after irradiation, there is a massive renewal of cells in the thymus from bone marrow precursors [2]

Original language	English
Pages (from-to)	449-454
Number of pages	6
Journal	Haematology and blood transfusion
Volume	29
DOIs	https://doi.org/10.1007/978-3-642-70385-0_93
Publication status	Published - 1985
Externally published	Yes

Access to Document

10.1007/978-3-642-70385-0_93

Cite this

@article{cdba2b7bffcc462e9b2325daa0892455,

title = "Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis",

abstract = "The thymus is believed to be the major, if not the sole site of differentiation of T lymphocytes [1, 2]. During fetal development the thymus receives a bolus of precursors of T cells from the hematopoietic organs, probably the fetal liver and/or the yolk sac [3, 4]; these populations subsequently undergo self-renewal as well as maturation [5]. In adult life the thymus receives cells from the bone marrow at a very low level, but in times of stress, or after irradiation, there is a massive renewal of cells in the thymus from bone marrow precursors [2]",

author = "Weissman, {Irving L} and McGrath, {M S} and Reichert, {R A} and Gallatin, {W M} and Sophie Ezine and P Fink and Butcher, {Eugene C} and J Marian and O'Neill, {H C}",

year = "1985",

doi = "10.1007/978-3-642-70385-0_93",

language = "English",

volume = "29",

pages = "449--454",

journal = "Haematology and blood transfusion",

issn = "0171-7111",

}

TY - JOUR

T1 - Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis

AU - Weissman, Irving L

AU - McGrath, M S

AU - Reichert, R A

AU - Gallatin, W M

AU - Ezine, Sophie

AU - Fink, P

AU - Butcher, Eugene C

AU - Marian, J

AU - O'Neill, H C

PY - 1985

Y1 - 1985

N2 - The thymus is believed to be the major, if not the sole site of differentiation of T lymphocytes [1, 2]. During fetal development the thymus receives a bolus of precursors of T cells from the hematopoietic organs, probably the fetal liver and/or the yolk sac [3, 4]; these populations subsequently undergo self-renewal as well as maturation [5]. In adult life the thymus receives cells from the bone marrow at a very low level, but in times of stress, or after irradiation, there is a massive renewal of cells in the thymus from bone marrow precursors [2]

AB - The thymus is believed to be the major, if not the sole site of differentiation of T lymphocytes [1, 2]. During fetal development the thymus receives a bolus of precursors of T cells from the hematopoietic organs, probably the fetal liver and/or the yolk sac [3, 4]; these populations subsequently undergo self-renewal as well as maturation [5]. In adult life the thymus receives cells from the bone marrow at a very low level, but in times of stress, or after irradiation, there is a massive renewal of cells in the thymus from bone marrow precursors [2]

U2 - 10.1007/978-3-642-70385-0_93

DO - 10.1007/978-3-642-70385-0_93

M3 - Article

C2 - 4029738

SN - 0171-7111

VL - 29

SP - 449

EP - 454

JO - Haematology and blood transfusion

JF - Haematology and blood transfusion

ER -

Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis

Abstract

Access to Document

Fingerprint

Cite this