Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis

Irving L Weissman, M S McGrath, R A Reichert, W M Gallatin, Sophie Ezine, P Fink, Eugene C Butcher, J Marian, H C O'Neill

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The thymus is believed to be the major, if not the sole site of differentiation of T lymphocytes [1, 2]. During fetal development the thymus receives a bolus of precursors of T cells from the hematopoietic organs, probably the fetal liver and/or the yolk sac [3, 4]; these populations subsequently undergo self-renewal as well as maturation [5]. In adult life the thymus receives cells from the bone marrow at a very low level, but in times of stress, or after irradiation, there is a massive renewal of cells in the thymus from bone marrow precursors [2]
Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalHaematology and blood transfusion
Volume29
DOIs
Publication statusPublished - 1985
Externally publishedYes

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