Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis

Irving L Weissman, M S McGrath, R A Reichert, W M Gallatin, Sophie Ezine, P Fink, Eugene C Butcher, J Marian, H C O'Neill

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The thymus is believed to be the major, if not the sole site of differentiation of T lymphocytes [1, 2]. During fetal development the thymus receives a bolus of precursors of T cells from the hematopoietic organs, probably the fetal liver and/or the yolk sac [3, 4]; these populations subsequently undergo self-renewal as well as maturation [5]. In adult life the thymus receives cells from the bone marrow at a very low level, but in times of stress, or after irradiation, there is a massive renewal of cells in the thymus from bone marrow precursors [2]
Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalHaematology and blood transfusion
Volume29
DOIs
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Thymus Gland
Lymphoma
Lymphocytes
T-Lymphoid Precursor Cells
Yolk Sac
Fetal Development
Bone Marrow Cells
Bone Marrow
T-Lymphocytes
Liver
Population

Cite this

Weissman, Irving L ; McGrath, M S ; Reichert, R A ; Gallatin, W M ; Ezine, Sophie ; Fink, P ; Butcher, Eugene C ; Marian, J ; O'Neill, H C. / Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis. In: Haematology and blood transfusion. 1985 ; Vol. 29. pp. 449-454.
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abstract = "The thymus is believed to be the major, if not the sole site of differentiation of T lymphocytes [1, 2]. During fetal development the thymus receives a bolus of precursors of T cells from the hematopoietic organs, probably the fetal liver and/or the yolk sac [3, 4]; these populations subsequently undergo self-renewal as well as maturation [5]. In adult life the thymus receives cells from the bone marrow at a very low level, but in times of stress, or after irradiation, there is a massive renewal of cells in the thymus from bone marrow precursors [2]",
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Weissman, IL, McGrath, MS, Reichert, RA, Gallatin, WM, Ezine, S, Fink, P, Butcher, EC, Marian, J & O'Neill, HC 1985, 'Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis' Haematology and blood transfusion, vol. 29, pp. 449-454. https://doi.org/10.1007/978-3-642-70385-0_93

Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis. / Weissman, Irving L; McGrath, M S; Reichert, R A; Gallatin, W M; Ezine, Sophie; Fink, P; Butcher, Eugene C; Marian, J; O'Neill, H C.

In: Haematology and blood transfusion, Vol. 29, 1985, p. 449-454.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis

AU - Weissman, Irving L

AU - McGrath, M S

AU - Reichert, R A

AU - Gallatin, W M

AU - Ezine, Sophie

AU - Fink, P

AU - Butcher, Eugene C

AU - Marian, J

AU - O'Neill, H C

PY - 1985

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AB - The thymus is believed to be the major, if not the sole site of differentiation of T lymphocytes [1, 2]. During fetal development the thymus receives a bolus of precursors of T cells from the hematopoietic organs, probably the fetal liver and/or the yolk sac [3, 4]; these populations subsequently undergo self-renewal as well as maturation [5]. In adult life the thymus receives cells from the bone marrow at a very low level, but in times of stress, or after irradiation, there is a massive renewal of cells in the thymus from bone marrow precursors [2]

U2 - 10.1007/978-3-642-70385-0_93

DO - 10.1007/978-3-642-70385-0_93

M3 - Article

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SP - 449

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JF - Haematology and blood transfusion

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