Longitudinal studies of cardiac troponin I in a large cohort of healthy children

Gus Koerbin, Julia M. Potter, Walter P. Abhayaratna, Richard D. Telford, Tony Badrick, Fred S. Apple, Allan S. Jaffe, Peter E. Hickman

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Abstract

BACKGROUND: There is little information available on cardiac troponin concentrations in healthy young children. METHODS: Using a precommercial high-sensitivity assay from Abbott Diagnostics, we measured cardiac troponin I (cTnI) in longitudinal blood samples collected at ages 8, 10, and 12 years from a cohort of healthy, community-dwelling children. The 99th percentile values were calculated and estimates of the long-term biological variation were made. RESULTS: cTnI concentrations were above the limit of detection in 87%, 90%, and 98%of the children at ages 8, 10, and 12 years. The 99th percentiles were lower compared to a healthy adult population in both male and female children at all ages studied. At the 3 periods of study assessment, different children had cTnI concentrations above the 99th percentile. The calculated 99th percentile varied markedly depending upon whether the lowest or highest cTnI measurement for an individual child was included in the calculation. Biological variation varied markedly between 0% and 136%, the index of individuality was low at 0.36, and the reference change value was an increase of 147% or a decrease of 59%. CONCLUSIONS: In this longitudinal study of cTnI concentrations in healthy children as determined by a high-sensitivity assay, different children had concentrations of cTnI above the 99th percentile at the 3 episodes of assessment. These results suggest that in children the 99th percentile may not be a reliable index of silent cardiac disease, but rather may be indicating low-grade intercurrent illness.

Original languageEnglish
Pages (from-to)1665-1672
Number of pages8
JournalClinical Chemistry
Volume58
Issue number12
DOIs
Publication statusPublished - Dec 2012

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Troponin I
Longitudinal Studies
Assays
Troponin
Independent Living
Blood
Individuality
Limit of Detection
Heart Diseases
Reference Values

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Koerbin, G., Potter, J. M., Abhayaratna, W. P., Telford, R. D., Badrick, T., Apple, F. S., ... Hickman, P. E. (2012). Longitudinal studies of cardiac troponin I in a large cohort of healthy children. Clinical Chemistry, 58(12), 1665-1672. https://doi.org/10.1373/clinchem.2012.192054
Koerbin, Gus ; Potter, Julia M. ; Abhayaratna, Walter P. ; Telford, Richard D. ; Badrick, Tony ; Apple, Fred S. ; Jaffe, Allan S. ; Hickman, Peter E. / Longitudinal studies of cardiac troponin I in a large cohort of healthy children. In: Clinical Chemistry. 2012 ; Vol. 58, No. 12. pp. 1665-1672.
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abstract = "BACKGROUND: There is little information available on cardiac troponin concentrations in healthy young children. METHODS: Using a precommercial high-sensitivity assay from Abbott Diagnostics, we measured cardiac troponin I (cTnI) in longitudinal blood samples collected at ages 8, 10, and 12 years from a cohort of healthy, community-dwelling children. The 99th percentile values were calculated and estimates of the long-term biological variation were made. RESULTS: cTnI concentrations were above the limit of detection in 87{\%}, 90{\%}, and 98{\%}of the children at ages 8, 10, and 12 years. The 99th percentiles were lower compared to a healthy adult population in both male and female children at all ages studied. At the 3 periods of study assessment, different children had cTnI concentrations above the 99th percentile. The calculated 99th percentile varied markedly depending upon whether the lowest or highest cTnI measurement for an individual child was included in the calculation. Biological variation varied markedly between 0{\%} and 136{\%}, the index of individuality was low at 0.36, and the reference change value was an increase of 147{\%} or a decrease of 59{\%}. CONCLUSIONS: In this longitudinal study of cTnI concentrations in healthy children as determined by a high-sensitivity assay, different children had concentrations of cTnI above the 99th percentile at the 3 episodes of assessment. These results suggest that in children the 99th percentile may not be a reliable index of silent cardiac disease, but rather may be indicating low-grade intercurrent illness.",
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Koerbin, G, Potter, JM, Abhayaratna, WP, Telford, RD, Badrick, T, Apple, FS, Jaffe, AS & Hickman, PE 2012, 'Longitudinal studies of cardiac troponin I in a large cohort of healthy children' Clinical Chemistry, vol. 58, no. 12, pp. 1665-1672. https://doi.org/10.1373/clinchem.2012.192054

Longitudinal studies of cardiac troponin I in a large cohort of healthy children. / Koerbin, Gus; Potter, Julia M.; Abhayaratna, Walter P.; Telford, Richard D.; Badrick, Tony; Apple, Fred S.; Jaffe, Allan S.; Hickman, Peter E.

In: Clinical Chemistry, Vol. 58, No. 12, 12.2012, p. 1665-1672.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Koerbin, Gus

AU - Potter, Julia M.

AU - Abhayaratna, Walter P.

AU - Telford, Richard D.

AU - Badrick, Tony

AU - Apple, Fred S.

AU - Jaffe, Allan S.

AU - Hickman, Peter E.

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N2 - BACKGROUND: There is little information available on cardiac troponin concentrations in healthy young children. METHODS: Using a precommercial high-sensitivity assay from Abbott Diagnostics, we measured cardiac troponin I (cTnI) in longitudinal blood samples collected at ages 8, 10, and 12 years from a cohort of healthy, community-dwelling children. The 99th percentile values were calculated and estimates of the long-term biological variation were made. RESULTS: cTnI concentrations were above the limit of detection in 87%, 90%, and 98%of the children at ages 8, 10, and 12 years. The 99th percentiles were lower compared to a healthy adult population in both male and female children at all ages studied. At the 3 periods of study assessment, different children had cTnI concentrations above the 99th percentile. The calculated 99th percentile varied markedly depending upon whether the lowest or highest cTnI measurement for an individual child was included in the calculation. Biological variation varied markedly between 0% and 136%, the index of individuality was low at 0.36, and the reference change value was an increase of 147% or a decrease of 59%. CONCLUSIONS: In this longitudinal study of cTnI concentrations in healthy children as determined by a high-sensitivity assay, different children had concentrations of cTnI above the 99th percentile at the 3 episodes of assessment. These results suggest that in children the 99th percentile may not be a reliable index of silent cardiac disease, but rather may be indicating low-grade intercurrent illness.

AB - BACKGROUND: There is little information available on cardiac troponin concentrations in healthy young children. METHODS: Using a precommercial high-sensitivity assay from Abbott Diagnostics, we measured cardiac troponin I (cTnI) in longitudinal blood samples collected at ages 8, 10, and 12 years from a cohort of healthy, community-dwelling children. The 99th percentile values were calculated and estimates of the long-term biological variation were made. RESULTS: cTnI concentrations were above the limit of detection in 87%, 90%, and 98%of the children at ages 8, 10, and 12 years. The 99th percentiles were lower compared to a healthy adult population in both male and female children at all ages studied. At the 3 periods of study assessment, different children had cTnI concentrations above the 99th percentile. The calculated 99th percentile varied markedly depending upon whether the lowest or highest cTnI measurement for an individual child was included in the calculation. Biological variation varied markedly between 0% and 136%, the index of individuality was low at 0.36, and the reference change value was an increase of 147% or a decrease of 59%. CONCLUSIONS: In this longitudinal study of cTnI concentrations in healthy children as determined by a high-sensitivity assay, different children had concentrations of cTnI above the 99th percentile at the 3 episodes of assessment. These results suggest that in children the 99th percentile may not be a reliable index of silent cardiac disease, but rather may be indicating low-grade intercurrent illness.

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DO - 10.1373/clinchem.2012.192054

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JO - Clinical Chemistry

JF - Clinical Chemistry

SN - 0009-9147

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Koerbin G, Potter JM, Abhayaratna WP, Telford RD, Badrick T, Apple FS et al. Longitudinal studies of cardiac troponin I in a large cohort of healthy children. Clinical Chemistry. 2012 Dec;58(12):1665-1672. https://doi.org/10.1373/clinchem.2012.192054