TY - JOUR
T1 - Lithium therapy and weight change in people with bipolar disorder: A systematic review and meta-analysis
AU - Gomes-da-Costa, Susana
AU - Marx, Wolfgang
AU - Corponi, Filippo
AU - Anmella, Gerard
AU - Murru, Andrea
AU - Pons-Cabrera, Maria Teresa
AU - Giménez-Palomo, Anna
AU - Gutiérrez-Arango, Felipe
AU - Llach, Cristian Daniel
AU - Fico, Giovanna
AU - Kotzalidis, Georgios D.
AU - Verdolini, Norma
AU - Valentí, Marc
AU - Berk, Michael
AU - Vieta, Eduard
AU - Pacchiarotti, Isabella
N1 - Funding Information:
EV thanks the support of the Spanish Ministry of Science and Innovation ( PI15/00283 , PI18/00805 ) integrated into the Plan Nacional de I + D+I and co-financed by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER) ; the Instituto de Salud Carlos III ; the CIBER of Mental Health (CIBERSAM) ; the Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement ( 2017 SGR 1365 ), the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357 . Thanks the support of the European Union Horizon 2020 research and innovation program ( EU.3.1.1. Understanding health, wellbeing and disease : Grant No 754907 and EU.3.1.3. Treating and managing disease : Grant No 945151 ).
Funding Information:
GA’s research is supported by a Pons Bartran 2020 grant ( PI046549 ).
Funding Information:
MB is supported by a NHMRC Senior Principal Research Fellowship ( 1156072 ), and has received Grant/Research Support from the NIH , Cooperative Research Centre , Simons Autism Foundation , Cancer Council of Victoria , Stanley Medical Research Foundation , Medical Benefits Fund , National Health and Medical Research Council , Medical Research Futures Fund , Beyond Blue , Rotary Health , A2 milk company , Meat and Livestock Board , Woolworths, Avant and the Harry Windsor Foundation .
Funding Information:
EV thanks the support of the Spanish Ministry of Science and Innovation (PI15/00283, PI18/00805) integrated into the Plan Nacional de I + D+I and co-financed by the ISCIII-Subdirecci?n General de Evaluaci?n and the Fondo Europeo de Desarrollo Regional (FEDER); the Instituto de Salud Carlos III; the CIBER of Mental Health (CIBERSAM); the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017 SGR 1365), the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357. Thanks the support of the European Union Horizon 2020 research and innovation program (EU.3.1.1. Understanding health, wellbeing and disease: Grant No 754907 and EU.3.1.3. Treating and managing disease: Grant No 945151). GA's research is supported by a Pons Bartran 2020 grant (PI046549). MB is supported by a NHMRC Senior Principal Research Fellowship (1156072), and has received Grant/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, Medical Benefits Fund, National Health and Medical Research Council, Medical Research Futures Fund, Beyond Blue, Rotary Health, A2 milk company, Meat and Livestock Board, Woolworths, Avant and the Harry Windsor Foundation.
Publisher Copyright:
© 2021 The Authors
PY - 2022/3
Y1 - 2022/3
N2 - Lithium remains the gold standard maintenance treatment for Bipolar Disorder (BD). However, weight gain is a side effect of increasing relevance due to its metabolic implications. We conducted a systematic review and meta-analysis aimed at summarizing evidence on the use of lithium and weight change in BD. We followed the PRISMA methodology, searching Pubmed, Scopus and Web of Science. From 1003 screened references, 20 studies were included in the systematic review and 9 included in the meta-analysis. In line with the studies included in the systematic review, the meta-analysis revealed that weight gain with lithium was not significant, noting a weight increase of 0.462 Kg (p = 0158). A shorter duration of treatment was significantly associated with more weight gain. Compared to placebo, there were no significant differences in weight gain. Weight gain was significantly lower with lithium than with active comparators. This work reveals a low impact of lithium on weight change, especially compared to some of the most widely used active comparators. Our results could impact clinical decisions.
AB - Lithium remains the gold standard maintenance treatment for Bipolar Disorder (BD). However, weight gain is a side effect of increasing relevance due to its metabolic implications. We conducted a systematic review and meta-analysis aimed at summarizing evidence on the use of lithium and weight change in BD. We followed the PRISMA methodology, searching Pubmed, Scopus and Web of Science. From 1003 screened references, 20 studies were included in the systematic review and 9 included in the meta-analysis. In line with the studies included in the systematic review, the meta-analysis revealed that weight gain with lithium was not significant, noting a weight increase of 0.462 Kg (p = 0158). A shorter duration of treatment was significantly associated with more weight gain. Compared to placebo, there were no significant differences in weight gain. Weight gain was significantly lower with lithium than with active comparators. This work reveals a low impact of lithium on weight change, especially compared to some of the most widely used active comparators. Our results could impact clinical decisions.
UR - http://www.scopus.com/inward/record.url?scp=85111859290&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2021.07.011
DO - 10.1016/j.neubiorev.2021.07.011
M3 - Review article
C2 - 34265322
AN - SCOPUS:85111859290
SN - 0149-7634
VL - 134
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 104266
ER -