Leukaemogenic progression: The importance of differentiation and associated genetic events

E S Ho, H C O'Neill

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal differentiation of cells has been shown to result in reversal of malignancy and death of the cancer cell. Clearly the development of cancer is not the result of a single oncogenic event, but rather a myriad of events which appear to proceed in concert in a step-wise fashion and which are likely to be influenced by the cellular environment. Here we review some of the major genetic changes which occur in leukaemogenesis and discuss the possible role of differentiative events in the development of leukaemia.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalImmunology and Cell Biology
Volume73
Issue number3
DOIs
Publication statusPublished - Jun 1995
Externally publishedYes

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Neoplasms
Cell Differentiation
Blood Cells
Leukemia
Cell Death

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title = "Leukaemogenic progression: The importance of differentiation and associated genetic events",
abstract = "A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal differentiation of cells has been shown to result in reversal of malignancy and death of the cancer cell. Clearly the development of cancer is not the result of a single oncogenic event, but rather a myriad of events which appear to proceed in concert in a step-wise fashion and which are likely to be influenced by the cellular environment. Here we review some of the major genetic changes which occur in leukaemogenesis and discuss the possible role of differentiative events in the development of leukaemia.",
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Leukaemogenic progression : The importance of differentiation and associated genetic events. / Ho, E S; O'Neill, H C.

In: Immunology and Cell Biology, Vol. 73, No. 3, 06.1995, p. 193-197.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Leukaemogenic progression

T2 - The importance of differentiation and associated genetic events

AU - Ho, E S

AU - O'Neill, H C

PY - 1995/6

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N2 - A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal differentiation of cells has been shown to result in reversal of malignancy and death of the cancer cell. Clearly the development of cancer is not the result of a single oncogenic event, but rather a myriad of events which appear to proceed in concert in a step-wise fashion and which are likely to be influenced by the cellular environment. Here we review some of the major genetic changes which occur in leukaemogenesis and discuss the possible role of differentiative events in the development of leukaemia.

AB - A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal differentiation of cells has been shown to result in reversal of malignancy and death of the cancer cell. Clearly the development of cancer is not the result of a single oncogenic event, but rather a myriad of events which appear to proceed in concert in a step-wise fashion and which are likely to be influenced by the cellular environment. Here we review some of the major genetic changes which occur in leukaemogenesis and discuss the possible role of differentiative events in the development of leukaemia.

U2 - 10.1038/icb.1995.32

DO - 10.1038/icb.1995.32

M3 - Review article

VL - 73

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JO - Australian Journal of Experimental Biology and Medical Science

JF - Australian Journal of Experimental Biology and Medical Science

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