Leukaemogenic progression: The importance of differentiation and associated genetic events

E S Ho, H C O'Neill

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal differentiation of cells has been shown to result in reversal of malignancy and death of the cancer cell. Clearly the development of cancer is not the result of a single oncogenic event, but rather a myriad of events which appear to proceed in concert in a step-wise fashion and which are likely to be influenced by the cellular environment. Here we review some of the major genetic changes which occur in leukaemogenesis and discuss the possible role of differentiative events in the development of leukaemia.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalImmunology and Cell Biology
Volume73
Issue number3
DOIs
Publication statusPublished - Jun 1995
Externally publishedYes

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