Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls

Caroline Giezenaar, Laurence G. Trahair, Rachael Rigda, Amy T. Hutchison, Christine Feinle-Bisset, Natalie D. Luscombe-Marsh, Trygve Hausken, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen

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Abstract

Protein-rich supplements are used widely for the management of malnutrition in young and older people. Protein is the most satiating of the macronutrients in young. It is not known how the effects of oral protein ingestion on energy intake, appetite, and gastric emptying are modified by age. The aim of the study was to determine the suppression of energy intake by protein compared with control and underlying gastric-emptying and appetite responses of oral whey protein drinks in eight healthy older men (69-80 yr) compared with eight young male controls (18-34 yr). Subjects were studied on three occasions to determine the effects of protein loads of 30 g/120 kcal and 70 g/280 kcal compared with a flavored water control-drink (0 g whey protein) on energy intake (ad libitum buffet-style meal), and gastric emptying (three-dimensional-ultrasonography) and appetite (0-180 min) in a randomized, double-blind, cross-over design. Energy intake was suppressed by the protein compared with control (P = 0.034). Suppression of energy intake by protein was less in older men (1 ± 5%) than in young controls (15 ± 2%; P= 0.008). Cumulative energy intake (meal+drink) on the protein drink days compared with the control day increased more in older (18 ± 6%) men than young (1 ± 3%) controls (P = 0.008). Gastric emptying of all three drinks was slower in older men (50% gastric-emptying time: 68 ± 5 min) than young controls (36 ± 5 min; P= 0.007). Appetite decreased in young, while it increased in older (P < 0.05). In summary, despite having slower gastric emptying, elderly men exhibited blunted protein-induced suppression of energy intake by whey protein compared with young controls, so that in the elderly men, protein ingestion increased overall energy intake more than in the young men.

Original languageEnglish
Pages (from-to)R845-R854
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume309
Issue number8
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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Energy Intake
Gastric Emptying
Appetite
Proteins
Meals
Eating
Whey Proteins
Malnutrition
Cross-Over Studies
Ultrasonography
Water

Cite this

Giezenaar, Caroline ; Trahair, Laurence G. ; Rigda, Rachael ; Hutchison, Amy T. ; Feinle-Bisset, Christine ; Luscombe-Marsh, Natalie D. ; Hausken, Trygve ; Jones, Karen L. ; Horowitz, Michael ; Chapman, Ian ; Soenen, Stijn. / Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2015 ; Vol. 309, No. 8. pp. R845-R854.
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title = "Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls",
abstract = "Protein-rich supplements are used widely for the management of malnutrition in young and older people. Protein is the most satiating of the macronutrients in young. It is not known how the effects of oral protein ingestion on energy intake, appetite, and gastric emptying are modified by age. The aim of the study was to determine the suppression of energy intake by protein compared with control and underlying gastric-emptying and appetite responses of oral whey protein drinks in eight healthy older men (69-80 yr) compared with eight young male controls (18-34 yr). Subjects were studied on three occasions to determine the effects of protein loads of 30 g/120 kcal and 70 g/280 kcal compared with a flavored water control-drink (0 g whey protein) on energy intake (ad libitum buffet-style meal), and gastric emptying (three-dimensional-ultrasonography) and appetite (0-180 min) in a randomized, double-blind, cross-over design. Energy intake was suppressed by the protein compared with control (P = 0.034). Suppression of energy intake by protein was less in older men (1 ± 5{\%}) than in young controls (15 ± 2{\%}; P= 0.008). Cumulative energy intake (meal+drink) on the protein drink days compared with the control day increased more in older (18 ± 6{\%}) men than young (1 ± 3{\%}) controls (P = 0.008). Gastric emptying of all three drinks was slower in older men (50{\%} gastric-emptying time: 68 ± 5 min) than young controls (36 ± 5 min; P= 0.007). Appetite decreased in young, while it increased in older (P < 0.05). In summary, despite having slower gastric emptying, elderly men exhibited blunted protein-induced suppression of energy intake by whey protein compared with young controls, so that in the elderly men, protein ingestion increased overall energy intake more than in the young men.",
author = "Caroline Giezenaar and Trahair, {Laurence G.} and Rachael Rigda and Hutchison, {Amy T.} and Christine Feinle-Bisset and Luscombe-Marsh, {Natalie D.} and Trygve Hausken and Jones, {Karen L.} and Michael Horowitz and Ian Chapman and Stijn Soenen",
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Giezenaar, C, Trahair, LG, Rigda, R, Hutchison, AT, Feinle-Bisset, C, Luscombe-Marsh, ND, Hausken, T, Jones, KL, Horowitz, M, Chapman, I & Soenen, S 2015, 'Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls' American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 309, no. 8, pp. R845-R854. https://doi.org/10.1152/ajpregu.00213.2015

Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls. / Giezenaar, Caroline; Trahair, Laurence G.; Rigda, Rachael; Hutchison, Amy T.; Feinle-Bisset, Christine; Luscombe-Marsh, Natalie D.; Hausken, Trygve; Jones, Karen L.; Horowitz, Michael; Chapman, Ian; Soenen, Stijn.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 309, No. 8, 01.01.2015, p. R845-R854.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls

AU - Giezenaar, Caroline

AU - Trahair, Laurence G.

AU - Rigda, Rachael

AU - Hutchison, Amy T.

AU - Feinle-Bisset, Christine

AU - Luscombe-Marsh, Natalie D.

AU - Hausken, Trygve

AU - Jones, Karen L.

AU - Horowitz, Michael

AU - Chapman, Ian

AU - Soenen, Stijn

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Y1 - 2015/1/1

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AB - Protein-rich supplements are used widely for the management of malnutrition in young and older people. Protein is the most satiating of the macronutrients in young. It is not known how the effects of oral protein ingestion on energy intake, appetite, and gastric emptying are modified by age. The aim of the study was to determine the suppression of energy intake by protein compared with control and underlying gastric-emptying and appetite responses of oral whey protein drinks in eight healthy older men (69-80 yr) compared with eight young male controls (18-34 yr). Subjects were studied on three occasions to determine the effects of protein loads of 30 g/120 kcal and 70 g/280 kcal compared with a flavored water control-drink (0 g whey protein) on energy intake (ad libitum buffet-style meal), and gastric emptying (three-dimensional-ultrasonography) and appetite (0-180 min) in a randomized, double-blind, cross-over design. Energy intake was suppressed by the protein compared with control (P = 0.034). Suppression of energy intake by protein was less in older men (1 ± 5%) than in young controls (15 ± 2%; P= 0.008). Cumulative energy intake (meal+drink) on the protein drink days compared with the control day increased more in older (18 ± 6%) men than young (1 ± 3%) controls (P = 0.008). Gastric emptying of all three drinks was slower in older men (50% gastric-emptying time: 68 ± 5 min) than young controls (36 ± 5 min; P= 0.007). Appetite decreased in young, while it increased in older (P < 0.05). In summary, despite having slower gastric emptying, elderly men exhibited blunted protein-induced suppression of energy intake by whey protein compared with young controls, so that in the elderly men, protein ingestion increased overall energy intake more than in the young men.

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