Isolation of a thymus-homing Lyt-2-, L3T4- T-cell line from mouse spleen

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Abstract

We have selectively isolated and transformed a population of T-cell-receptor+, Lyt-2-, L3T4- cytotoxic T cells from mouse spleen following stimulation in vivo with a radiation leukemia virus-induced thymoma, C6VL/1. The two sublines analyzed here were found to induce tumors with primarily thymic involvement and one of these has been shown to have specific homing capacity for the thymus. Properties displayed by this cell line are evidence that T cells do exist in peripheral lymphoid tissue which can traffic back to the thymus and that Lyt-2-, L3T4- immature T cells can enter peripheral lymphoid organs.

Original languageEnglish
Pages (from-to)222-230
Number of pages9
JournalCellular Immunology
Volume109
Issue number1
DOIs
Publication statusPublished - 1 Oct 1987
Externally publishedYes

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Thymus Gland
Spleen
T-Lymphocytes
Cell Line
Radiation Leukemia Virus
Thymoma
Lymphoid Tissue
T-Cell Antigen Receptor
Population
Neoplasms

Cite this

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abstract = "We have selectively isolated and transformed a population of T-cell-receptor+, Lyt-2-, L3T4- cytotoxic T cells from mouse spleen following stimulation in vivo with a radiation leukemia virus-induced thymoma, C6VL/1. The two sublines analyzed here were found to induce tumors with primarily thymic involvement and one of these has been shown to have specific homing capacity for the thymus. Properties displayed by this cell line are evidence that T cells do exist in peripheral lymphoid tissue which can traffic back to the thymus and that Lyt-2-, L3T4- immature T cells can enter peripheral lymphoid organs.",
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Isolation of a thymus-homing Lyt-2-, L3T4- T-cell line from mouse spleen. / O'Neill, H C.

In: Cellular Immunology, Vol. 109, No. 1, 01.10.1987, p. 222-230.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Isolation of a thymus-homing Lyt-2-, L3T4- T-cell line from mouse spleen

AU - O'Neill, H C

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N2 - We have selectively isolated and transformed a population of T-cell-receptor+, Lyt-2-, L3T4- cytotoxic T cells from mouse spleen following stimulation in vivo with a radiation leukemia virus-induced thymoma, C6VL/1. The two sublines analyzed here were found to induce tumors with primarily thymic involvement and one of these has been shown to have specific homing capacity for the thymus. Properties displayed by this cell line are evidence that T cells do exist in peripheral lymphoid tissue which can traffic back to the thymus and that Lyt-2-, L3T4- immature T cells can enter peripheral lymphoid organs.

AB - We have selectively isolated and transformed a population of T-cell-receptor+, Lyt-2-, L3T4- cytotoxic T cells from mouse spleen following stimulation in vivo with a radiation leukemia virus-induced thymoma, C6VL/1. The two sublines analyzed here were found to induce tumors with primarily thymic involvement and one of these has been shown to have specific homing capacity for the thymus. Properties displayed by this cell line are evidence that T cells do exist in peripheral lymphoid tissue which can traffic back to the thymus and that Lyt-2-, L3T4- immature T cells can enter peripheral lymphoid organs.

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JO - Cellular Immunology

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