TY - JOUR
T1 - Is Vitamin D level at melanoma diagnosis associated with stage of tumor? An observational study of melanoma patients living in a high ultraviolet radiation environment
AU - Kimlin, Michael G.
AU - Youl, Pip
AU - Baade, Peter
AU - Rye, Sheree
AU - Brodie, Alison
N1 - Funding Information:
This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Cancer Research Program Log number CA140415, under Award No. W81XWH-15-1-0541. Michael G. Kimlin is supported through a Cancer Council Queensland Professorial Chair in Cancer Prevention. This supplement was sponsored by the Office of the Secretary of Defense for Health Affairs.
Publisher Copyright:
© 2019 Association of Military Surgeons of the United States. All rights reserved.
PY - 2019/3/21
Y1 - 2019/3/21
N2 - Objectives:This study will assess the relationship between vitamin D concentration at melanoma diagnosis and melanoma tumor characteristics, in individuals in a high ultraviolet radiation (UVR) environment. Methods:We aim to recruit 600 recently diagnosed melanoma patients from Queensland, Australia, a high UVR location with one of the world's highest melanoma incidence rates. Patients are recruited through general practitioner, skin cancer specialist, dermatological and hospital-based practices. As close as possible to diagnosis, participants provide a blood sample for vitamin D analysis and have their sun exposure/sun protection behavior, melanoma risk factors and dietary vitamin D intake assessed by questionnaire and phone interview. Details of tumor pathology, including tumor level, thickness, and ulceration, are abstracted from cancer registry records. Here, we describe the study methods and present preliminary findings from early participants. Results:As of December 2017, we have recruited 128 participants (48% male, mean age 60.2 years, mean Breslow thickness 0.63 mm). Conclusions:When complete, this study will give insights into the association between vitamin D at diagnosis and melanoma tumor characteristics whilst adjusting for recent sun exposure and sun protection use. This study may impact military sun exposure and nutrition policies as vitamin D may play a role in melanomagenesis.
AB - Objectives:This study will assess the relationship between vitamin D concentration at melanoma diagnosis and melanoma tumor characteristics, in individuals in a high ultraviolet radiation (UVR) environment. Methods:We aim to recruit 600 recently diagnosed melanoma patients from Queensland, Australia, a high UVR location with one of the world's highest melanoma incidence rates. Patients are recruited through general practitioner, skin cancer specialist, dermatological and hospital-based practices. As close as possible to diagnosis, participants provide a blood sample for vitamin D analysis and have their sun exposure/sun protection behavior, melanoma risk factors and dietary vitamin D intake assessed by questionnaire and phone interview. Details of tumor pathology, including tumor level, thickness, and ulceration, are abstracted from cancer registry records. Here, we describe the study methods and present preliminary findings from early participants. Results:As of December 2017, we have recruited 128 participants (48% male, mean age 60.2 years, mean Breslow thickness 0.63 mm). Conclusions:When complete, this study will give insights into the association between vitamin D at diagnosis and melanoma tumor characteristics whilst adjusting for recent sun exposure and sun protection use. This study may impact military sun exposure and nutrition policies as vitamin D may play a role in melanomagenesis.
UR - http://www.scopus.com/inward/record.url?scp=85063674623&partnerID=8YFLogxK
U2 - 10.1093/milmed/usy384
DO - 10.1093/milmed/usy384
M3 - Article
C2 - 30901465
AN - SCOPUS:85063674623
SN - 0026-4075
VL - 184
SP - 506
EP - 510
JO - Military Medicine
JF - Military Medicine
ER -