Is the antiprogestin RU486 luteolytic in rats?

Len Martin, L. H. Crane

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Subcutaneous injections of RU486 on Day 1, Day 4 or Days 3 and 4 of pregnancy in rats induced abortion of the embryo and transient vaginal cornification. Nevertheless, most corpora lutea appeared to be functional at autopsy on Day 12. The same treatments in pseudopregnant rats also produced transient vaginal cornification, but did not terminate pseudopregnancy. This suggests that transient antagonism of progesterone by RU486 does not terminate function of the corpus luteum in rats and that positive feedback by progesterone is not essential for continuing luteal function in rats.

Original languageEnglish
Pages (from-to)615-619
Number of pages5
JournalReproduction, Fertility and Development
Volume3
Issue number5
DOIs
Publication statusPublished - 1 Jan 1991
Externally publishedYes

Fingerprint

Corpus Luteum
corpus luteum
rats
Progesterone
progesterone
Pseudopregnancy
induced abortion
pseudopregnancy
Induced Abortion
subcutaneous injection
Subcutaneous Injections
Autopsy
necropsy
embryo (animal)
Embryonic Structures
pregnancy
Pregnancy
Therapeutics

Cite this

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title = "Is the antiprogestin RU486 luteolytic in rats?",
abstract = "Subcutaneous injections of RU486 on Day 1, Day 4 or Days 3 and 4 of pregnancy in rats induced abortion of the embryo and transient vaginal cornification. Nevertheless, most corpora lutea appeared to be functional at autopsy on Day 12. The same treatments in pseudopregnant rats also produced transient vaginal cornification, but did not terminate pseudopregnancy. This suggests that transient antagonism of progesterone by RU486 does not terminate function of the corpus luteum in rats and that positive feedback by progesterone is not essential for continuing luteal function in rats.",
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Is the antiprogestin RU486 luteolytic in rats? / Martin, Len; Crane, L. H.

In: Reproduction, Fertility and Development, Vol. 3, No. 5, 01.01.1991, p. 615-619.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Is the antiprogestin RU486 luteolytic in rats?

AU - Martin, Len

AU - Crane, L. H.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Subcutaneous injections of RU486 on Day 1, Day 4 or Days 3 and 4 of pregnancy in rats induced abortion of the embryo and transient vaginal cornification. Nevertheless, most corpora lutea appeared to be functional at autopsy on Day 12. The same treatments in pseudopregnant rats also produced transient vaginal cornification, but did not terminate pseudopregnancy. This suggests that transient antagonism of progesterone by RU486 does not terminate function of the corpus luteum in rats and that positive feedback by progesterone is not essential for continuing luteal function in rats.

AB - Subcutaneous injections of RU486 on Day 1, Day 4 or Days 3 and 4 of pregnancy in rats induced abortion of the embryo and transient vaginal cornification. Nevertheless, most corpora lutea appeared to be functional at autopsy on Day 12. The same treatments in pseudopregnant rats also produced transient vaginal cornification, but did not terminate pseudopregnancy. This suggests that transient antagonism of progesterone by RU486 does not terminate function of the corpus luteum in rats and that positive feedback by progesterone is not essential for continuing luteal function in rats.

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