Is afternoon cortisol more reliable than waking cortisol in association studies of children with an ASD?

Christopher F. Sharpley, Vicki Bitsika, Nicholas M. Andronicos, Linda L. Agnew

    Research output: Contribution to journalReview articleResearchpeer-review

    5 Citations (Scopus)

    Abstract

    Salivary cortisol may be used as a biomarker of stress and anxiety in children with an Autism Spectrum Disorder (ASD) and is particularly valuable in studies of the association between stress-related cortisol concentrations and other factors such as comorbid disorders or aspects of the ASD phenotype. Although protocols for the collection of cortisol shortly after waking are often based on the assumption of the presence of a diurnal rhythm in cortisol, that rhythm may not be as reliable in children with an ASD as in non-ASD children. Alternatively, collecting cortisol during the afternoon may represent a more reliable procedure with less inter-participant variability.

    Original languageEnglish
    Pages (from-to)218-223
    Number of pages6
    JournalPhysiology and Behavior
    Volume155
    DOIs
    Publication statusPublished - 1 Mar 2016

    Fingerprint

    Hydrocortisone
    Circadian Rhythm
    Anxiety
    Biomarkers
    Autism Spectrum Disorder
    Cortisol
    Autism Spectrum Disorders
    Phenotype
    Rhythm

    Cite this

    Sharpley, Christopher F. ; Bitsika, Vicki ; Andronicos, Nicholas M. ; Agnew, Linda L. / Is afternoon cortisol more reliable than waking cortisol in association studies of children with an ASD?. In: Physiology and Behavior. 2016 ; Vol. 155. pp. 218-223.
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    Is afternoon cortisol more reliable than waking cortisol in association studies of children with an ASD? / Sharpley, Christopher F.; Bitsika, Vicki; Andronicos, Nicholas M.; Agnew, Linda L.

    In: Physiology and Behavior, Vol. 155, 01.03.2016, p. 218-223.

    Research output: Contribution to journalReview articleResearchpeer-review

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