Investigation of the role of the GABRG2 gene variant in migraine

Timothy Chen, Melanie Murrell, Javed Y Fowdar, Bishakha Roy, Rebecca Grealy, Lyn R Griffiths

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Migraine is the most common neurological disorder worldwide affecting about 12% of the worldwide population. This disorder has been classed into two main types of migraine-with and without aura. While a number of factors can influence the onset of migraine, a major factor is that of genetics. The GABAA gene encodes for the GABAA receptor. Along with other receptors, the GABAA receptor is involved in the mediation of neuronal activities. In this study, a GABRG2 gene (GABAA receptor gamma-2-subunit) SNP (rs211037) was genotyped on a migraine case-control population of 546 (273 affected and an equal number of healthy) individuals. Using specifically designed primers, a high resolution melt (HRM) assay was carried out in the genotyping process. After genotyping, results were compared in the case and control populations. Analysis of results showed no significant differences in the allele frequencies between case and control populations. Similarly no differences were detected for subtypes or for a specific gender of migraine (p>0.05). Although this gene has been previously found to be involved in febrile seizures and there is some co-morbidity between epilepsy and migraine, we decided to investigate this marker for involvement in migraine. The results did not support a role for the tested GABRG2 variant in migraine.

Original languageEnglish
Pages (from-to)112-4
Number of pages3
JournalJournal of the Neurological Sciences
Volume318
Issue number1-2
DOIs
Publication statusPublished - 15 Jul 2012
Externally publishedYes

Fingerprint

Migraine Disorders
Genes
GABA-A Receptors
Population
Migraine without Aura
Migraine with Aura
Febrile Seizures
Nervous System Diseases
Gene Frequency
Single Nucleotide Polymorphism
Epilepsy
Morbidity

Cite this

Chen, T., Murrell, M., Fowdar, J. Y., Roy, B., Grealy, R., & Griffiths, L. R. (2012). Investigation of the role of the GABRG2 gene variant in migraine. Journal of the Neurological Sciences, 318(1-2), 112-4. https://doi.org/10.1016/j.jns.2012.03.014
Chen, Timothy ; Murrell, Melanie ; Fowdar, Javed Y ; Roy, Bishakha ; Grealy, Rebecca ; Griffiths, Lyn R. / Investigation of the role of the GABRG2 gene variant in migraine. In: Journal of the Neurological Sciences. 2012 ; Vol. 318, No. 1-2. pp. 112-4.
@article{8312d381fecd496fa65ef26fd73133e2,
title = "Investigation of the role of the GABRG2 gene variant in migraine",
abstract = "Migraine is the most common neurological disorder worldwide affecting about 12{\%} of the worldwide population. This disorder has been classed into two main types of migraine-with and without aura. While a number of factors can influence the onset of migraine, a major factor is that of genetics. The GABAA gene encodes for the GABAA receptor. Along with other receptors, the GABAA receptor is involved in the mediation of neuronal activities. In this study, a GABRG2 gene (GABAA receptor gamma-2-subunit) SNP (rs211037) was genotyped on a migraine case-control population of 546 (273 affected and an equal number of healthy) individuals. Using specifically designed primers, a high resolution melt (HRM) assay was carried out in the genotyping process. After genotyping, results were compared in the case and control populations. Analysis of results showed no significant differences in the allele frequencies between case and control populations. Similarly no differences were detected for subtypes or for a specific gender of migraine (p>0.05). Although this gene has been previously found to be involved in febrile seizures and there is some co-morbidity between epilepsy and migraine, we decided to investigate this marker for involvement in migraine. The results did not support a role for the tested GABRG2 variant in migraine.",
author = "Timothy Chen and Melanie Murrell and Fowdar, {Javed Y} and Bishakha Roy and Rebecca Grealy and Griffiths, {Lyn R}",
note = "Copyright {\circledC} 2012 Elsevier B.V. All rights reserved.",
year = "2012",
month = "7",
day = "15",
doi = "10.1016/j.jns.2012.03.014",
language = "English",
volume = "318",
pages = "112--4",
journal = "World neurology",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

Chen, T, Murrell, M, Fowdar, JY, Roy, B, Grealy, R & Griffiths, LR 2012, 'Investigation of the role of the GABRG2 gene variant in migraine' Journal of the Neurological Sciences, vol. 318, no. 1-2, pp. 112-4. https://doi.org/10.1016/j.jns.2012.03.014

Investigation of the role of the GABRG2 gene variant in migraine. / Chen, Timothy; Murrell, Melanie; Fowdar, Javed Y; Roy, Bishakha; Grealy, Rebecca; Griffiths, Lyn R.

In: Journal of the Neurological Sciences, Vol. 318, No. 1-2, 15.07.2012, p. 112-4.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Investigation of the role of the GABRG2 gene variant in migraine

AU - Chen, Timothy

AU - Murrell, Melanie

AU - Fowdar, Javed Y

AU - Roy, Bishakha

AU - Grealy, Rebecca

AU - Griffiths, Lyn R

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2012/7/15

Y1 - 2012/7/15

N2 - Migraine is the most common neurological disorder worldwide affecting about 12% of the worldwide population. This disorder has been classed into two main types of migraine-with and without aura. While a number of factors can influence the onset of migraine, a major factor is that of genetics. The GABAA gene encodes for the GABAA receptor. Along with other receptors, the GABAA receptor is involved in the mediation of neuronal activities. In this study, a GABRG2 gene (GABAA receptor gamma-2-subunit) SNP (rs211037) was genotyped on a migraine case-control population of 546 (273 affected and an equal number of healthy) individuals. Using specifically designed primers, a high resolution melt (HRM) assay was carried out in the genotyping process. After genotyping, results were compared in the case and control populations. Analysis of results showed no significant differences in the allele frequencies between case and control populations. Similarly no differences were detected for subtypes or for a specific gender of migraine (p>0.05). Although this gene has been previously found to be involved in febrile seizures and there is some co-morbidity between epilepsy and migraine, we decided to investigate this marker for involvement in migraine. The results did not support a role for the tested GABRG2 variant in migraine.

AB - Migraine is the most common neurological disorder worldwide affecting about 12% of the worldwide population. This disorder has been classed into two main types of migraine-with and without aura. While a number of factors can influence the onset of migraine, a major factor is that of genetics. The GABAA gene encodes for the GABAA receptor. Along with other receptors, the GABAA receptor is involved in the mediation of neuronal activities. In this study, a GABRG2 gene (GABAA receptor gamma-2-subunit) SNP (rs211037) was genotyped on a migraine case-control population of 546 (273 affected and an equal number of healthy) individuals. Using specifically designed primers, a high resolution melt (HRM) assay was carried out in the genotyping process. After genotyping, results were compared in the case and control populations. Analysis of results showed no significant differences in the allele frequencies between case and control populations. Similarly no differences were detected for subtypes or for a specific gender of migraine (p>0.05). Although this gene has been previously found to be involved in febrile seizures and there is some co-morbidity between epilepsy and migraine, we decided to investigate this marker for involvement in migraine. The results did not support a role for the tested GABRG2 variant in migraine.

U2 - 10.1016/j.jns.2012.03.014

DO - 10.1016/j.jns.2012.03.014

M3 - Article

VL - 318

SP - 112

EP - 114

JO - World neurology

JF - World neurology

SN - 0022-510X

IS - 1-2

ER -