Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine

Rob Curtain, Rod A. Lea, S. Quinlan, C. Bellis, L. Tajouri, R. Hughes, J MacMillan, Lyn R. Griffiths

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Abstract

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene on chromosome 19p13.2 performing an association analysis in 244 typical migraine-affected patients, 151 suffering from migraine with aura (MA), 96 with migraine without aura (MO) and 244 unaffected controls. The populations consisted of Caucasians only, and controls were age- and sex-matched. The results showed no significant difference between groups for allele frequency distributions of the (TA)n polymorphism even after separation of the migraine-affected individuals into subgroups of MA and MO affected patients. This is in contradiction to Mochi et al. [Mochi M, Cevoli S, Cortelli P, Pierangeli G, Scapoli C, Soriani S, Montagna P. Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migrane without aura. J Neurol Sci 2003; 213 (1-2): 7-10.] who found a positive association of this variant with MO. Our study discusses possible differences between the two studies and extends this research by investigating circulating cholesterol levels in a migraine-affected population.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalJournal of the Neurological Sciences
Volume227
Issue number1
DOIs
Publication statusPublished - 15 Dec 2004
Externally publishedYes

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LDL Receptors
Migraine Disorders
LDL Cholesterol
Migraine with Aura
Cholesterol
Genes
Migraine without Aura
Cell Surface Receptors
Psychological Stress
Gene Frequency
Population
Exons
Epilepsy
Homeostasis
Chromosomes
Research

Cite this

Curtain, Rob ; Lea, Rod A. ; Quinlan, S. ; Bellis, C. ; Tajouri, L. ; Hughes, R. ; MacMillan, J ; Griffiths, Lyn R. / Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine. In: Journal of the Neurological Sciences. 2004 ; Vol. 227, No. 1. pp. 95-100.
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Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine. / Curtain, Rob; Lea, Rod A.; Quinlan, S.; Bellis, C.; Tajouri, L.; Hughes, R.; MacMillan, J; Griffiths, Lyn R.

In: Journal of the Neurological Sciences, Vol. 227, No. 1, 15.12.2004, p. 95-100.

Research output: Contribution to journalArticleResearchpeer-review

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