In aging males low serum testosterone is associated with cardiovascular disease. Testosterone replacement (TRT) can improve symptoms of cardiovascular disease, and in animal models of early atherosclerosis, such as the cholesterol-fed testicular feminised mouse (Tfm), TRT is also atheroprotective (Nettleship et al. 2007). The mechanisms underlying this are unclear, but since atherosclerosis is a chronic inflammatory disease testosterone may have an anti-inflammatory role.
|Number of pages||1|
|Publication status||Published - 2010|
|Event||ASCEPT 44th Annual Scientific Meeting 2010 : Found in Translation: Integrated Approaches to Drug Development - Melbourne , Australia|
Duration: 28 Nov 2010 → 1 Dec 2010
|Conference||ASCEPT 44th Annual Scientific Meeting 2010|
|Period||28/11/10 → 1/12/10|
Sellers, D. J., Woodroofe, M. N., Jones, T. H., Channer, K. S., & Kelly, D. M. (2010). Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model. 12-12. Abstract from ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia. http://ascept.eproceedings.com.au/papers/p13.pdf