Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model

Donna J Sellers, M Nicola Woodroofe, T. Hugh Jones, Kevin S. Channer, Daniel M. Kelly

Research output: Contribution to conferenceAbstractResearchpeer-review

Abstract

In aging males low serum testosterone is associated with cardiovascular disease. Testosterone replacement (TRT) can improve symptoms of cardiovascular disease, and in animal models of early atherosclerosis, such as the cholesterol-fed testicular feminised mouse (Tfm), TRT is also atheroprotective (Nettleship et al. 2007). The mechanisms underlying this are unclear, but since atherosclerosis is a chronic inflammatory disease testosterone may have an anti-inflammatory role.
Original languageEnglish
Pages12-12
Number of pages1
Publication statusPublished - 2010
EventASCEPT 44th Annual Scientific Meeting 2010 : Found in Translation: Integrated Approaches to Drug Development - Melbourne , Australia
Duration: 28 Nov 20101 Dec 2010
http://ascept.eproceedings.com.au/

Conference

ConferenceASCEPT 44th Annual Scientific Meeting 2010
Abbreviated titleASCEPT
CountryAustralia
CityMelbourne
Period28/11/101/12/10
Internet address

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Testosterone
Atherosclerosis
Cardiovascular Diseases
Chronic Disease
Anti-Inflammatory Agents
Animal Models
Cholesterol
Serum

Cite this

Sellers, D. J., Woodroofe, M. N., Jones, T. H., Channer, K. S., & Kelly, D. M. (2010). Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model. 12-12. Abstract from ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia.
Sellers, Donna J ; Woodroofe, M Nicola ; Jones, T. Hugh ; Channer, Kevin S. ; Kelly, Daniel M. / Investigating the atheroprotective effect of testosterone : Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model. Abstract from ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia.1 p.
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Sellers, DJ, Woodroofe, MN, Jones, TH, Channer, KS & Kelly, DM 2010, 'Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model' ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia, 28/11/10 - 1/12/10, pp. 12-12.

Investigating the atheroprotective effect of testosterone : Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model. / Sellers, Donna J; Woodroofe, M Nicola; Jones, T. Hugh; Channer, Kevin S.; Kelly, Daniel M.

2010. 12-12 Abstract from ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia.

Research output: Contribution to conferenceAbstractResearchpeer-review

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AB - In aging males low serum testosterone is associated with cardiovascular disease. Testosterone replacement (TRT) can improve symptoms of cardiovascular disease, and in animal models of early atherosclerosis, such as the cholesterol-fed testicular feminised mouse (Tfm), TRT is also atheroprotective (Nettleship et al. 2007). The mechanisms underlying this are unclear, but since atherosclerosis is a chronic inflammatory disease testosterone may have an anti-inflammatory role.

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Sellers DJ, Woodroofe MN, Jones TH, Channer KS, Kelly DM. Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model. 2010. Abstract from ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia.