Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model

Donna J Sellers; M Nicola Woodroofe; T. Hugh Jones; Kevin S. Channer; Daniel M. Kelly

Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model

Donna J Sellers, M Nicola Woodroofe, T. Hugh Jones, Kevin S. Channer, Daniel M. Kelly

Faculty of Health Sciences & Medicine

Research output: Contribution to conference › Abstract › Research › peer-review

Abstract

In aging males low serum testosterone is associated with cardiovascular disease. Testosterone replacement (TRT) can improve symptoms of cardiovascular disease, and in animal models of early atherosclerosis, such as the cholesterol-fed testicular feminised mouse (Tfm), TRT is also atheroprotective (Nettleship et al. 2007). The mechanisms underlying this are unclear, but since atherosclerosis is a chronic inflammatory disease testosterone may have an anti-inflammatory role.

Original language	English
Pages	12-12
Number of pages	1
Publication status	Published - 2010
Event	ASCEPT 44th Annual Scientific Meeting 2010 : Found in Translation: Integrated Approaches to Drug Development - Melbourne , Australia Duration: 28 Nov 2010 → 1 Dec 2010 http://ascept.eproceedings.com.au/

Conference

Conference	ASCEPT 44th Annual Scientific Meeting 2010
Abbreviated title	ASCEPT
Country/Territory	Australia
City	Melbourne
Period	28/11/10 → 1/12/10
Internet address	http://ascept.eproceedings.com.au/

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Sellers, D. J., Woodroofe, M. N., Jones, T. H., Channer, K. S., & Kelly, D. M. (2010). Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model. 12-12. Abstract from ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia. http://ascept.eproceedings.com.au/papers/p13.pdf

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title = "Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model",

abstract = "In aging males low serum testosterone is associated with cardiovascular disease. Testosterone replacement (TRT) can improve symptoms of cardiovascular disease, and in animal models of early atherosclerosis, such as the cholesterol-fed testicular feminised mouse (Tfm), TRT is also atheroprotective (Nettleship et al. 2007). The mechanisms underlying this are unclear, but since atherosclerosis is a chronic inflammatory disease testosterone may have an anti-inflammatory role.",

author = "Sellers, {Donna J} and Woodroofe, {M Nicola} and Jones, {T. Hugh} and Channer, {Kevin S.} and Kelly, {Daniel M.}",

year = "2010",

language = "English",

pages = "12--12",

note = "ASCEPT 44th Annual Scientific Meeting 2010 : Found in Translation: Integrated Approaches to Drug Development, ASCEPT ; Conference date: 28-11-2010 Through 01-12-2010",

url = "http://ascept.eproceedings.com.au/",

}

Sellers, DJ, Woodroofe, MN, Jones, TH, Channer, KS & Kelly, DM 2010, 'Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model', ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia, 28/11/10 - 1/12/10 pp. 12-12. <http://ascept.eproceedings.com.au/papers/p13.pdf>

Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model. / Sellers, Donna J; Woodroofe, M Nicola; Jones, T. Hugh et al.
2010. 12-12 Abstract from ASCEPT 44th Annual Scientific Meeting 2010 , Melbourne , Australia.

Research output: Contribution to conference › Abstract › Research › peer-review

TY - CONF

T1 - Investigating the atheroprotective effect of testosterone

T2 - ASCEPT 44th Annual Scientific Meeting 2010

AU - Sellers, Donna J

AU - Woodroofe, M Nicola

AU - Jones, T. Hugh

AU - Channer, Kevin S.

AU - Kelly, Daniel M.

PY - 2010

Y1 - 2010

N2 - In aging males low serum testosterone is associated with cardiovascular disease. Testosterone replacement (TRT) can improve symptoms of cardiovascular disease, and in animal models of early atherosclerosis, such as the cholesterol-fed testicular feminised mouse (Tfm), TRT is also atheroprotective (Nettleship et al. 2007). The mechanisms underlying this are unclear, but since atherosclerosis is a chronic inflammatory disease testosterone may have an anti-inflammatory role.

AB - In aging males low serum testosterone is associated with cardiovascular disease. Testosterone replacement (TRT) can improve symptoms of cardiovascular disease, and in animal models of early atherosclerosis, such as the cholesterol-fed testicular feminised mouse (Tfm), TRT is also atheroprotective (Nettleship et al. 2007). The mechanisms underlying this are unclear, but since atherosclerosis is a chronic inflammatory disease testosterone may have an anti-inflammatory role.

M3 - Abstract

SP - 12

EP - 12

Y2 - 28 November 2010 through 1 December 2010

ER -

Investigating the atheroprotective effect of testosterone: Role in modulation of inflammatory markers in the development of early atherogenesis in the testicular feminised mouse model

Abstract

Conference

UN SDGs

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