TY - JOUR
T1 - Interrelations between cognitive dysfunction and motor symptoms of Parkinson's disease: Behavioral and neural studies
AU - Moustafa, Ahmed A.
AU - Chakravarthy, Srinivasa
AU - Phillips, Joseph R.
AU - Crouse, Jacob J.
AU - Gupta, Ankur
AU - Frank, Michael J.
AU - Hall, Julie M.
AU - Jahanshahi, Marjan
N1 - De Gruyter allows authors the use of the final published version of an article (publisher pdf) for self-archiving (author's personal website) and/or archiving in an institutional repository (on a non-profit server) after an embargo period of 12 months after publication.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (tremor, bradykinesia/akinesia, and rigidity), PD patients also show other motor deficits, including gait disturbance, speech deficits, and impaired handwriting. However, along with these key motor symptoms, PD patients also experience cognitive deficits in attention, executive function, working memory, and learning. Recent evidence suggests that these motor and cognitive deficits of PD are not completely dissociable, as aspects of cognitive dysfunction can impact motor performance in PD. In this article, we provide a review of behavioral and neural studies on the associations between motor symptoms and cognitive deficits in PD, specifically akinesia/bradykinesia, tremor, gait, handwriting, precision grip, and speech production. This review paves the way for providing a framework for understanding how treatment of cognitive dysfunction, for example cognitive rehabilitation programs, may in turn influence the motor symptoms of PD.
AB - Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (tremor, bradykinesia/akinesia, and rigidity), PD patients also show other motor deficits, including gait disturbance, speech deficits, and impaired handwriting. However, along with these key motor symptoms, PD patients also experience cognitive deficits in attention, executive function, working memory, and learning. Recent evidence suggests that these motor and cognitive deficits of PD are not completely dissociable, as aspects of cognitive dysfunction can impact motor performance in PD. In this article, we provide a review of behavioral and neural studies on the associations between motor symptoms and cognitive deficits in PD, specifically akinesia/bradykinesia, tremor, gait, handwriting, precision grip, and speech production. This review paves the way for providing a framework for understanding how treatment of cognitive dysfunction, for example cognitive rehabilitation programs, may in turn influence the motor symptoms of PD.
UR - http://www.scopus.com/inward/record.url?scp=84978043713&partnerID=8YFLogxK
U2 - 10.1515/revneuro-2015-0070
DO - 10.1515/revneuro-2015-0070
M3 - Review article
C2 - 26982614
AN - SCOPUS:84978043713
SN - 0334-1763
VL - 27
SP - 535
EP - 548
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
IS - 5
ER -