Interrelations between cognitive dysfunction and motor symptoms of Parkinson's disease: Behavioral and neural studies

Ahmed A. Moustafa*, Srinivasa Chakravarthy, Joseph R. Phillips, Jacob J. Crouse, Ankur Gupta, Michael J. Frank, Julie M. Hall, Marjan Jahanshahi

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

17 Citations (Scopus)
4 Downloads (Pure)

Abstract

Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (tremor, bradykinesia/akinesia, and rigidity), PD patients also show other motor deficits, including gait disturbance, speech deficits, and impaired handwriting. However, along with these key motor symptoms, PD patients also experience cognitive deficits in attention, executive function, working memory, and learning. Recent evidence suggests that these motor and cognitive deficits of PD are not completely dissociable, as aspects of cognitive dysfunction can impact motor performance in PD. In this article, we provide a review of behavioral and neural studies on the associations between motor symptoms and cognitive deficits in PD, specifically akinesia/bradykinesia, tremor, gait, handwriting, precision grip, and speech production. This review paves the way for providing a framework for understanding how treatment of cognitive dysfunction, for example cognitive rehabilitation programs, may in turn influence the motor symptoms of PD.

Original languageEnglish
Pages (from-to)535-548
Number of pages14
JournalReviews in the Neurosciences
Volume27
Issue number5
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

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