Interpreting diagnostic tests with continuous results and no gold standard: A common scenario explained using the tuberculin skin test

Claudia C. Dobler*, M. Hassan Murad

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
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Practitioners of evidence-based medicine commonly encounter diagnostic tests with continuous results and no gold standard. In contrast, the traditional critical appraisal teachings assume a binary test (2×2 table) with a gold standard. In this guide, we use the example of the tuberculin skin test to illustrate a simple approach facilitated by using stratum-specific likelihood ratios and odds of developing future patient-important events. This approach can aid practitioners in the interpretation and application of diagnostic tests to patient care.

Original languageEnglish
Pages (from-to)199-201
Number of pages3
JournalBMJ Evidence-Based Medicine
Issue number6
Publication statusPublished - 1 Dec 2017
Externally publishedYes


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