TY - JOUR
T1 - Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review
AU - Misiak, Błażej
AU - Stramecki, Filip
AU - Gawęda, Łukasz
AU - Prochwicz, Katarzyna
AU - Sąsiadek, Maria M.
AU - Moustafa, Ahmed A.
AU - Frydecka, Dorota
N1 - Funding Information:
Acknowledgements ŁG was supported by the Ministry of Higher Education and Science of Republic of Poland (0295/E-393/STY/10/ 2015, 1258/MOB/IV/2015/0).
Publisher Copyright:
© 2017, The Author(s).
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution of genetic factors to the etiology of these disorders is increasingly being recognized as the action of multiple risk variants with small effect sizes, which might explain only a minor part of susceptibility. On the other site, numerous environmental factors have been found to play an important role in their causality. Therefore, in recent years, several studies focused on gene × environment interactions that are believed to bridge the gap between genetic underpinnings and environmental insults. In this article, we performed a systematic review of studies investigating gene × environment interactions in BD and schizophrenia spectrum phenotypes. In the majority of studies from this field, interacting effects of variation in genes encoding catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF), and FK506-binding protein 5 (FKBP5) have been explored. Almost consistently, these studies revealed that polymorphisms in COMT, BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or dependence, influencing various outcomes of schizophrenia spectrum disorders and BD. Other interactions still require further replication in larger clinical and non-clinical samples. In addition, future studies should address the direction of causality and potential mechanisms of the relationship between gene × environment interactions and various categories of outcomes in schizophrenia and BD.
AB - Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution of genetic factors to the etiology of these disorders is increasingly being recognized as the action of multiple risk variants with small effect sizes, which might explain only a minor part of susceptibility. On the other site, numerous environmental factors have been found to play an important role in their causality. Therefore, in recent years, several studies focused on gene × environment interactions that are believed to bridge the gap between genetic underpinnings and environmental insults. In this article, we performed a systematic review of studies investigating gene × environment interactions in BD and schizophrenia spectrum phenotypes. In the majority of studies from this field, interacting effects of variation in genes encoding catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF), and FK506-binding protein 5 (FKBP5) have been explored. Almost consistently, these studies revealed that polymorphisms in COMT, BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or dependence, influencing various outcomes of schizophrenia spectrum disorders and BD. Other interactions still require further replication in larger clinical and non-clinical samples. In addition, future studies should address the direction of causality and potential mechanisms of the relationship between gene × environment interactions and various categories of outcomes in schizophrenia and BD.
UR - http://www.scopus.com/inward/record.url?scp=85027704866&partnerID=8YFLogxK
U2 - 10.1007/s12035-017-0708-y
DO - 10.1007/s12035-017-0708-y
M3 - Review article
C2 - 28822116
AN - SCOPUS:85027704866
SN - 0893-7648
VL - 55
SP - 5075
EP - 5100
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 6
ER -