Inter- and intra-subject variability of neuromagnetic resting state networks

Vincent Wens*, Mathieu Bourguignon, Serge Goldman, Brice Marty, Marc Op De Beeck, Catherine Clumeck, Alison Mary, Philippe Peigneux, Patrick Van Bogaert, Matthew J. Brookes, Xavier De Tiège

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Functional connectivity studies conducted at the group level using magnetoencephalography (MEG) suggest that resting state networks (RSNs) emerge from the large-scale envelope correlation structure within spontaneous oscillatory brain activity. However, little is known about the consistency of MEG RSNs at the individual level. This paper investigates the inter- and intra-subject variability of three MEG RSNs (sensorimotor, auditory and visual) using seed-based source space envelope correlation analysis applied to 5 min of resting state MEG data acquired from a 306-channel whole-scalp neuromagnetometer (Elekta Oy, Helsinki, Finland) and source projected with minimum norm estimation. The main finding is that these three MEG RSNs exhibit substantial variability at the single-subject level across and within individuals, which depends on the RSN type, but can be reduced after averaging over subjects or sessions. Over- and under-estimations of true RSNs variability are respectively obtained using template seeds, which are potentially mislocated due to inter-subject variations, and a seed optimization method minimizing variability. In particular, bounds on the minimal number of subjects or sessions required to obtain highly consistent between- or within-subject averages of MEG RSNs are derived. Furthermore, MEG RSN topography positively correlates with their mean connectivity at the inter-subject level. These results indicate that MEG RSNs associated with primary cortices can be robustly extracted from seed-based envelope correlation and adequate averaging. MEG thus appears to be a valid technique to compare RSNs across subjects or conditions, at least when using the current methods.

Original languageEnglish
Pages (from-to)620-634
Number of pages15
JournalBrain Topography
Volume27
Issue number5
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

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Magnetoencephalography
Seeds
Finland
Scalp

Cite this

Wens, V., Bourguignon, M., Goldman, S., Marty, B., Op De Beeck, M., Clumeck, C., ... De Tiège, X. (2014). Inter- and intra-subject variability of neuromagnetic resting state networks. Brain Topography, 27(5), 620-634. https://doi.org/10.1007/s10548-014-0364-8
Wens, Vincent ; Bourguignon, Mathieu ; Goldman, Serge ; Marty, Brice ; Op De Beeck, Marc ; Clumeck, Catherine ; Mary, Alison ; Peigneux, Philippe ; Van Bogaert, Patrick ; Brookes, Matthew J. ; De Tiège, Xavier. / Inter- and intra-subject variability of neuromagnetic resting state networks. In: Brain Topography. 2014 ; Vol. 27, No. 5. pp. 620-634.
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Wens, V, Bourguignon, M, Goldman, S, Marty, B, Op De Beeck, M, Clumeck, C, Mary, A, Peigneux, P, Van Bogaert, P, Brookes, MJ & De Tiège, X 2014, 'Inter- and intra-subject variability of neuromagnetic resting state networks', Brain Topography, vol. 27, no. 5, pp. 620-634. https://doi.org/10.1007/s10548-014-0364-8

Inter- and intra-subject variability of neuromagnetic resting state networks. / Wens, Vincent; Bourguignon, Mathieu; Goldman, Serge; Marty, Brice; Op De Beeck, Marc; Clumeck, Catherine; Mary, Alison; Peigneux, Philippe; Van Bogaert, Patrick; Brookes, Matthew J.; De Tiège, Xavier.

In: Brain Topography, Vol. 27, No. 5, 01.01.2014, p. 620-634.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Bourguignon, Mathieu

AU - Goldman, Serge

AU - Marty, Brice

AU - Op De Beeck, Marc

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AU - Mary, Alison

AU - Peigneux, Philippe

AU - Van Bogaert, Patrick

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AU - De Tiège, Xavier

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Wens V, Bourguignon M, Goldman S, Marty B, Op De Beeck M, Clumeck C et al. Inter- and intra-subject variability of neuromagnetic resting state networks. Brain Topography. 2014 Jan 1;27(5):620-634. https://doi.org/10.1007/s10548-014-0364-8