Abstract
Hypothesis / aims of study
Faecal incontinence affects over 18 million adults in the US and has a huge impact on the quality of life of patients. The internal anal sphincter smooth muscle is central in maintaining faecal continence, contributing up to 85% to the anal resting pressure (1). Thus, understandably, it is a potential target for drugs to treat faecal incontinence. In the lower urinary tract, the lining of the bladder, the urothelium/lamina propria, releases a number of factors thought to be involved in bladder control. Specifically of interest, the urothelium/lamina propria releases a factor which inhibits contraction of the smooth muscle (2, 3). The aim of this study was to examine whether a similar mechanism operates to inhibit contractility of the smooth muscle of the internal anal sphincter.
Faecal incontinence affects over 18 million adults in the US and has a huge impact on the quality of life of patients. The internal anal sphincter smooth muscle is central in maintaining faecal continence, contributing up to 85% to the anal resting pressure (1). Thus, understandably, it is a potential target for drugs to treat faecal incontinence. In the lower urinary tract, the lining of the bladder, the urothelium/lamina propria, releases a number of factors thought to be involved in bladder control. Specifically of interest, the urothelium/lamina propria releases a factor which inhibits contraction of the smooth muscle (2, 3). The aim of this study was to examine whether a similar mechanism operates to inhibit contractility of the smooth muscle of the internal anal sphincter.
Original language | English |
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Article number | 457 |
Pages (from-to) | S414-S415 |
Number of pages | 2 |
Journal | Neurourology and Urodynamics |
Volume | 35 |
Issue number | S4 |
DOIs | |
Publication status | Published - Aug 2016 |
Event | Annual Meeting of the International-Continence-Society (ICS) - Tokyo, Japan Duration: 13 Sept 2016 → 16 Sept 2016 |