Inhibitory effect of the mucosa on contractile responses of the internal anal sphincter

O. Dixelius, R. Chess-Williams, M. Winder, D. Sellers

Research output: Contribution to journalMeeting AbstractResearchpeer-review


Hypothesis / aims of study
Faecal incontinence affects over 18 million adults in the US and has a huge impact on the quality of life of patients. The internal anal sphincter smooth muscle is central in maintaining faecal continence, contributing up to 85% to the anal resting pressure (1). Thus, understandably, it is a potential target for drugs to treat faecal incontinence. In the lower urinary tract, the lining of the bladder, the urothelium/lamina propria, releases a number of factors thought to be involved in bladder control. Specifically of interest, the urothelium/lamina propria releases a factor which inhibits contraction of the smooth muscle (2, 3). The aim of this study was to examine whether a similar mechanism operates to inhibit contractility of the smooth muscle of the internal anal sphincter.
Original languageEnglish
Article number457
Pages (from-to)S414-S415
Number of pages2
JournalNeurourology and Urodynamics
Issue numberS4
Publication statusPublished - Aug 2016
EventAnnual Meeting of the International-Continence-Society (ICS) - Tokyo, Japan
Duration: 13 Sept 201616 Sept 2016


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