Inhibitory effect of the mucosa on contractile responses of the internal anal sphincter

O. Dixelius, R. Chess-Williams, M. Winder, D. Sellers

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Abstract

Hypothesis / aims of study
Faecal incontinence affects over 18 million adults in the US and has a huge impact on the quality of life of patients. The internal anal sphincter smooth muscle is central in maintaining faecal continence, contributing up to 85% to the anal resting pressure (1). Thus, understandably, it is a potential target for drugs to treat faecal incontinence. In the lower urinary tract, the lining of the bladder, the urothelium/lamina propria, releases a number of factors thought to be involved in bladder control. Specifically of interest, the urothelium/lamina propria releases a factor which inhibits contraction of the smooth muscle (2, 3). The aim of this study was to examine whether a similar mechanism operates to inhibit contractility of the smooth muscle of the internal anal sphincter.
Original languageEnglish
Article number457
Pages (from-to)S414-S415
Number of pages2
JournalNeurourology and Urodynamics
Volume35
Issue numberS4
DOIs
Publication statusPublished - Aug 2016
EventAnnual Meeting of the International-Continence-Society (ICS) - Tokyo, Japan
Duration: 13 Sep 201616 Sep 2016

Cite this

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title = "Inhibitory effect of the mucosa on contractile responses of the internal anal sphincter",
abstract = "Hypothesis / aims of study Faecal incontinence affects over 18 million adults in the US and has a huge impact on the quality of life of patients. The internal anal sphincter smooth muscle is central in maintaining faecal continence, contributing up to 85{\%} to the anal resting pressure (1). Thus, understandably, it is a potential target for drugs to treat faecal incontinence. In the lower urinary tract, the lining of the bladder, the urothelium/lamina propria, releases a number of factors thought to be involved in bladder control. Specifically of interest, the urothelium/lamina propria releases a factor which inhibits contraction of the smooth muscle (2, 3). The aim of this study was to examine whether a similar mechanism operates to inhibit contractility of the smooth muscle of the internal anal sphincter.",
author = "O. Dixelius and R. Chess-Williams and M. Winder and D. Sellers",
year = "2016",
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journal = "Neurourology and Urodynamics",
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Inhibitory effect of the mucosa on contractile responses of the internal anal sphincter. / Dixelius, O.; Chess-Williams, R.; Winder, M.; Sellers, D.

In: Neurourology and Urodynamics, Vol. 35, No. S4, 457, 08.2016, p. S414-S415.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

TY - JOUR

T1 - Inhibitory effect of the mucosa on contractile responses of the internal anal sphincter

AU - Dixelius, O.

AU - Chess-Williams, R.

AU - Winder, M.

AU - Sellers, D.

PY - 2016/8

Y1 - 2016/8

N2 - Hypothesis / aims of study Faecal incontinence affects over 18 million adults in the US and has a huge impact on the quality of life of patients. The internal anal sphincter smooth muscle is central in maintaining faecal continence, contributing up to 85% to the anal resting pressure (1). Thus, understandably, it is a potential target for drugs to treat faecal incontinence. In the lower urinary tract, the lining of the bladder, the urothelium/lamina propria, releases a number of factors thought to be involved in bladder control. Specifically of interest, the urothelium/lamina propria releases a factor which inhibits contraction of the smooth muscle (2, 3). The aim of this study was to examine whether a similar mechanism operates to inhibit contractility of the smooth muscle of the internal anal sphincter.

AB - Hypothesis / aims of study Faecal incontinence affects over 18 million adults in the US and has a huge impact on the quality of life of patients. The internal anal sphincter smooth muscle is central in maintaining faecal continence, contributing up to 85% to the anal resting pressure (1). Thus, understandably, it is a potential target for drugs to treat faecal incontinence. In the lower urinary tract, the lining of the bladder, the urothelium/lamina propria, releases a number of factors thought to be involved in bladder control. Specifically of interest, the urothelium/lamina propria releases a factor which inhibits contraction of the smooth muscle (2, 3). The aim of this study was to examine whether a similar mechanism operates to inhibit contractility of the smooth muscle of the internal anal sphincter.

U2 - 10.1002/nau.23074

DO - 10.1002/nau.23074

M3 - Meeting Abstract

VL - 35

SP - S414-S415

JO - Neurourology and Urodynamics

JF - Neurourology and Urodynamics

SN - 0733-2467

IS - S4

M1 - 457

ER -