TY - JOUR
T1 - Inhibition of cell proliferation, vascular endothelial growth factor and tumor growth by albendazole
AU - Pourgholami, Mohammad Hossein
AU - Cai, Zhao Yan
AU - Wang, L.isa
AU - Badar, Samina
AU - Links, M.
AU - Morris, David Lawson
PY - 2009
Y1 - 2009
N2 - Vascular endothelial growth factor (VEGF) is the key molecule mediating tumor growth and malignant ascites formation. We recently reported that, in an end stage OVCAR-3 xenograft model, albendazole (ABZ) suppresses ascites formation, but not tumor growth. Hence, in the present study, we assessed the effect of ABZ on in vitro OVCAR-3 cell proliferation plus in vivo tumor growth, however, initiating ABZ treatment at mid stage (3 weeks post cell inoculation) rather than end stage disease. Here, ABZ treatment led to potent inhibition of cell proliferation, VEGF suppression, complete inhibition of ascites formation and most strikingly arrest of tumor growth.
AB - Vascular endothelial growth factor (VEGF) is the key molecule mediating tumor growth and malignant ascites formation. We recently reported that, in an end stage OVCAR-3 xenograft model, albendazole (ABZ) suppresses ascites formation, but not tumor growth. Hence, in the present study, we assessed the effect of ABZ on in vitro OVCAR-3 cell proliferation plus in vivo tumor growth, however, initiating ABZ treatment at mid stage (3 weeks post cell inoculation) rather than end stage disease. Here, ABZ treatment led to potent inhibition of cell proliferation, VEGF suppression, complete inhibition of ascites formation and most strikingly arrest of tumor growth.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-60849094088&partnerID=MN8TOARS
U2 - 10.1080/07357900802210752
DO - 10.1080/07357900802210752
M3 - Article
SN - 0735-7907
VL - 27
SP - 171
EP - 177
JO - Cancer Investigation
JF - Cancer Investigation
IS - 2
ER -