In vitro hematopoiesis reveals a novel dendritic-like cell present in murine spleen

Pravin Periasamy, Helen C O'Neill

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for hematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell subset has been shown to exist in spleen also supports that hypothesis. Studies have been directed at investigating the specific functional role of this novel subset as an APC accessible to blood-borne antigen, as well as the conditions under which hematopoiesis is initiated in spleen, and the type of progenitor involved.

Original languageEnglish
Pages (from-to)365-369
Number of pages5
JournalCurrent Stem Cell Research and Therapy
Volume8
Issue number5
DOIs
Publication statusPublished - Sep 2013
Externally publishedYes

Fingerprint

Hematopoiesis
Dendritic Cells
Spleen
Antigen-Presenting Cells
Adaptive Immunity
Lymphoid Tissue
In Vitro Techniques
Seeds
Bone Marrow
Phenotype
Antigens

Cite this

@article{a46093b841904a2f968e3d456d8376d1,
title = "In vitro hematopoiesis reveals a novel dendritic-like cell present in murine spleen",
abstract = "Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for hematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell subset has been shown to exist in spleen also supports that hypothesis. Studies have been directed at investigating the specific functional role of this novel subset as an APC accessible to blood-borne antigen, as well as the conditions under which hematopoiesis is initiated in spleen, and the type of progenitor involved.",
author = "Pravin Periasamy and O'Neill, {Helen C}",
year = "2013",
month = "9",
doi = "10.2174/1574888X113089990050",
language = "English",
volume = "8",
pages = "365--369",
journal = "Current stem cell research & therapy",
issn = "1574-888X",
publisher = "Bentham Science Publishers",
number = "5",

}

In vitro hematopoiesis reveals a novel dendritic-like cell present in murine spleen. / Periasamy, Pravin; O'Neill, Helen C.

In: Current Stem Cell Research and Therapy, Vol. 8, No. 5, 09.2013, p. 365-369.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - In vitro hematopoiesis reveals a novel dendritic-like cell present in murine spleen

AU - Periasamy, Pravin

AU - O'Neill, Helen C

PY - 2013/9

Y1 - 2013/9

N2 - Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for hematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell subset has been shown to exist in spleen also supports that hypothesis. Studies have been directed at investigating the specific functional role of this novel subset as an APC accessible to blood-borne antigen, as well as the conditions under which hematopoiesis is initiated in spleen, and the type of progenitor involved.

AB - Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for hematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell subset has been shown to exist in spleen also supports that hypothesis. Studies have been directed at investigating the specific functional role of this novel subset as an APC accessible to blood-borne antigen, as well as the conditions under which hematopoiesis is initiated in spleen, and the type of progenitor involved.

U2 - 10.2174/1574888X113089990050

DO - 10.2174/1574888X113089990050

M3 - Article

VL - 8

SP - 365

EP - 369

JO - Current stem cell research & therapy

JF - Current stem cell research & therapy

SN - 1574-888X

IS - 5

ER -