In vitro haematopoiesis of a novel dendritic-like cell present in murine spleen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for haematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell subset has been shown to exist in spleen also supports that hypothesis. Studies have been directed at investigating the specific functional role of this novel subset as an APC accessible to blood-borne antigen, as well as the conditions under which haematopoiesis is initiated in spleen, and the type of progenitor involved.

Original languageEnglish
Pages (from-to)367-71
Number of pages5
JournalCurrent Stem Cell Research and Therapy
Volume5
Issue number4
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

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Hematopoiesis
Dendritic Cells
Spleen
Antigen-Presenting Cells
Adaptive Immunity
Lymphoid Tissue
In Vitro Techniques
Seeds
Bone Marrow
Phenotype
Antigens

Cite this

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title = "In vitro haematopoiesis of a novel dendritic-like cell present in murine spleen",
abstract = "Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for haematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell subset has been shown to exist in spleen also supports that hypothesis. Studies have been directed at investigating the specific functional role of this novel subset as an APC accessible to blood-borne antigen, as well as the conditions under which haematopoiesis is initiated in spleen, and the type of progenitor involved.",
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In vitro haematopoiesis of a novel dendritic-like cell present in murine spleen. / Tan, Jonathan K H; O'Neill, Helen C.

In: Current Stem Cell Research and Therapy, Vol. 5, No. 4, 12.2010, p. 367-71.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for haematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell subset has been shown to exist in spleen also supports that hypothesis. Studies have been directed at investigating the specific functional role of this novel subset as an APC accessible to blood-borne antigen, as well as the conditions under which haematopoiesis is initiated in spleen, and the type of progenitor involved.

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