Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS: An open protocol case series

Caroline H S Barwood, Bruce E. Murdoch, Brooke Mai Whelan, David Lloyd, Stephan Riek, John D. O'Sullivan, Alan Coulthard, Andrew Wong

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) has been identified as a potentially valuable tool for the rehabilitation of language impairment after left hemisphere (LH) stroke, in populations of persons with chronic aphasia. Applied to a homologue to Broca's area, rTMS is posited to modulate bilateral language networks, promoting measurable behavioral language change, in accordance with theories of transcallosal disinhibition arising from the damaged LH. Objective/Hypothesis: The current investigation is an open-label study, presenting detailed case and group presentations on a population of seven nonfluent aphasic participants. Behavioral language performance is presented on expressive and receptive language measures up to 8 months after a 10-day protocol of 1 Hz stimulation. This research aims to provide longitudinal behavioral language outcomes for persons with aphasia, subsequent to rTMS and supplement previous studies to inform the clinical efficacy of rTMS. Results: In accordance with previous investigations, significant improvements in picture naming, spontaneous elicited speech and auditory comprehension were found. Time of testing was identified as a significant main effect. Significant improvements in picture naming accuracy and decreases in picture naming latency were also identified. The results demonstrate sustained language improvements up to 8 months subsequent to TMS application. Conclusions: The results of this investigation are consistent with the findings of previous research studies, reporting behavioral language changes after rTMS in nonfluent aphasia. Additional evidence is provided to demonstrate that rTMS may facilitate retrieval mechanisms involved in picture naming.

Original languageEnglish
Pages (from-to)274-286
Number of pages13
JournalBrain Stimulation
Volume5
Issue number3
DOIs
Publication statusPublished - Jul 2012
Externally publishedYes

Fingerprint

Aptitude
Transcranial Magnetic Stimulation
Language
Stroke
Aphasia
Broca Aphasia
Research
Population
Rehabilitation

Cite this

Barwood, Caroline H S ; Murdoch, Bruce E. ; Whelan, Brooke Mai ; Lloyd, David ; Riek, Stephan ; O'Sullivan, John D. ; Coulthard, Alan ; Wong, Andrew. / Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS : An open protocol case series. In: Brain Stimulation. 2012 ; Vol. 5, No. 3. pp. 274-286.
@article{4cb2b00e796b4a888591546e28e4d4c4,
title = "Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS: An open protocol case series",
abstract = "Background: Repetitive transcranial magnetic stimulation (rTMS) has been identified as a potentially valuable tool for the rehabilitation of language impairment after left hemisphere (LH) stroke, in populations of persons with chronic aphasia. Applied to a homologue to Broca's area, rTMS is posited to modulate bilateral language networks, promoting measurable behavioral language change, in accordance with theories of transcallosal disinhibition arising from the damaged LH. Objective/Hypothesis: The current investigation is an open-label study, presenting detailed case and group presentations on a population of seven nonfluent aphasic participants. Behavioral language performance is presented on expressive and receptive language measures up to 8 months after a 10-day protocol of 1 Hz stimulation. This research aims to provide longitudinal behavioral language outcomes for persons with aphasia, subsequent to rTMS and supplement previous studies to inform the clinical efficacy of rTMS. Results: In accordance with previous investigations, significant improvements in picture naming, spontaneous elicited speech and auditory comprehension were found. Time of testing was identified as a significant main effect. Significant improvements in picture naming accuracy and decreases in picture naming latency were also identified. The results demonstrate sustained language improvements up to 8 months subsequent to TMS application. Conclusions: The results of this investigation are consistent with the findings of previous research studies, reporting behavioral language changes after rTMS in nonfluent aphasia. Additional evidence is provided to demonstrate that rTMS may facilitate retrieval mechanisms involved in picture naming.",
author = "Barwood, {Caroline H S} and Murdoch, {Bruce E.} and Whelan, {Brooke Mai} and David Lloyd and Stephan Riek and O'Sullivan, {John D.} and Alan Coulthard and Andrew Wong",
year = "2012",
month = "7",
doi = "10.1016/j.brs.2011.03.005",
language = "English",
volume = "5",
pages = "274--286",
journal = "Brain Stimulation",
issn = "1935-861X",
publisher = "Elsevier",
number = "3",

}

Barwood, CHS, Murdoch, BE, Whelan, BM, Lloyd, D, Riek, S, O'Sullivan, JD, Coulthard, A & Wong, A 2012, 'Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS: An open protocol case series' Brain Stimulation, vol. 5, no. 3, pp. 274-286. https://doi.org/10.1016/j.brs.2011.03.005

Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS : An open protocol case series. / Barwood, Caroline H S; Murdoch, Bruce E.; Whelan, Brooke Mai; Lloyd, David; Riek, Stephan; O'Sullivan, John D.; Coulthard, Alan; Wong, Andrew.

In: Brain Stimulation, Vol. 5, No. 3, 07.2012, p. 274-286.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS

T2 - An open protocol case series

AU - Barwood, Caroline H S

AU - Murdoch, Bruce E.

AU - Whelan, Brooke Mai

AU - Lloyd, David

AU - Riek, Stephan

AU - O'Sullivan, John D.

AU - Coulthard, Alan

AU - Wong, Andrew

PY - 2012/7

Y1 - 2012/7

N2 - Background: Repetitive transcranial magnetic stimulation (rTMS) has been identified as a potentially valuable tool for the rehabilitation of language impairment after left hemisphere (LH) stroke, in populations of persons with chronic aphasia. Applied to a homologue to Broca's area, rTMS is posited to modulate bilateral language networks, promoting measurable behavioral language change, in accordance with theories of transcallosal disinhibition arising from the damaged LH. Objective/Hypothesis: The current investigation is an open-label study, presenting detailed case and group presentations on a population of seven nonfluent aphasic participants. Behavioral language performance is presented on expressive and receptive language measures up to 8 months after a 10-day protocol of 1 Hz stimulation. This research aims to provide longitudinal behavioral language outcomes for persons with aphasia, subsequent to rTMS and supplement previous studies to inform the clinical efficacy of rTMS. Results: In accordance with previous investigations, significant improvements in picture naming, spontaneous elicited speech and auditory comprehension were found. Time of testing was identified as a significant main effect. Significant improvements in picture naming accuracy and decreases in picture naming latency were also identified. The results demonstrate sustained language improvements up to 8 months subsequent to TMS application. Conclusions: The results of this investigation are consistent with the findings of previous research studies, reporting behavioral language changes after rTMS in nonfluent aphasia. Additional evidence is provided to demonstrate that rTMS may facilitate retrieval mechanisms involved in picture naming.

AB - Background: Repetitive transcranial magnetic stimulation (rTMS) has been identified as a potentially valuable tool for the rehabilitation of language impairment after left hemisphere (LH) stroke, in populations of persons with chronic aphasia. Applied to a homologue to Broca's area, rTMS is posited to modulate bilateral language networks, promoting measurable behavioral language change, in accordance with theories of transcallosal disinhibition arising from the damaged LH. Objective/Hypothesis: The current investigation is an open-label study, presenting detailed case and group presentations on a population of seven nonfluent aphasic participants. Behavioral language performance is presented on expressive and receptive language measures up to 8 months after a 10-day protocol of 1 Hz stimulation. This research aims to provide longitudinal behavioral language outcomes for persons with aphasia, subsequent to rTMS and supplement previous studies to inform the clinical efficacy of rTMS. Results: In accordance with previous investigations, significant improvements in picture naming, spontaneous elicited speech and auditory comprehension were found. Time of testing was identified as a significant main effect. Significant improvements in picture naming accuracy and decreases in picture naming latency were also identified. The results demonstrate sustained language improvements up to 8 months subsequent to TMS application. Conclusions: The results of this investigation are consistent with the findings of previous research studies, reporting behavioral language changes after rTMS in nonfluent aphasia. Additional evidence is provided to demonstrate that rTMS may facilitate retrieval mechanisms involved in picture naming.

UR - http://www.scopus.com/inward/record.url?scp=84861309697&partnerID=8YFLogxK

U2 - 10.1016/j.brs.2011.03.005

DO - 10.1016/j.brs.2011.03.005

M3 - Article

VL - 5

SP - 274

EP - 286

JO - Brain Stimulation

JF - Brain Stimulation

SN - 1935-861X

IS - 3

ER -