Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A. Eeles; Ali Amin Al Olama; Sara Benlloch; Edward J. Saunders; Daniel A. Leongamornlert; Malgorzata Tymrakiewicz; Maya Ghoussaini; Craig Luccarini; Joe Dennis; Sarah Jugurnauth-Little; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Jyotsna Batra

doi:10.1038/ng.2560

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A. Eeles^*
, Ali Amin Al Olama
, Sara Benlloch
, Edward J. Saunders
, Daniel A. Leongamornlert
, Malgorzata Tymrakiewicz
, Maya Ghoussaini
, Craig Luccarini
, Joe Dennis
, Sarah Jugurnauth-Little
, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
, Jyotsna Batra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

Original language	English
Pages (from-to)	385-391
Number of pages	7
Journal	Nature Genetics
Volume	45
Issue number	4
DOIs	https://doi.org/10.1038/ng.2560
Publication status	Published - 27 Mar 2013
Externally published	Yes

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10.1038/ng.2560

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Eeles, R. A., Olama, A. A. A., Benlloch, S., Saunders, E. J., Leongamornlert, D. A., Tymrakiewicz, M., Ghoussaini, M., Luccarini, C., Dennis, J., Jugurnauth-Little, S., The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, & Batra, J. (2013). Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics, 45(4), 385-391. https://doi.org/10.1038/ng.2560

@article{2ee3d57600de4468bd98346cc6fbcc10,

title = "Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array",

abstract = "Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30\% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1\% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.",

author = "Eeles, \{Rosalind A.\} and Olama, \{Ali Amin Al\} and Sara Benlloch and Saunders, \{Edward J.\} and Leongamornlert, \{Daniel A.\} and Malgorzata Tymrakiewicz and Maya Ghoussaini and Craig Luccarini and Joe Dennis and Sarah Jugurnauth-Little and \{The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium\} and Tokhir Dadaev and Neal, \{David E.\} and Hamdy, \{Freddie C.\} and Donovan, \{Jenny L.\} and Ken Muir and Giles, \{Graham G.\} and Gianluca Severi and Fredrik Wiklund and Henrik Gronberg and Haiman, \{Christopher A.\} and Fredrick Schumacher and Henderson, \{Brian E.\} and \{Le Marchand\}, Loic and Sara Lindstrom and Peter Kraft and Hunter, \{David J.\} and Susan Gapstur and Chanock, \{Stephen J.\} and Berndt, \{Sonja I.\} and Demetrius Albanes and Gerald Andriole and Johanna Schleutker and Maren Weischer and Federico Canzian and Elio Riboli and Key, \{Tim J.\} and Travis, \{Ruth C.\} and Daniele Campa and Ingles, \{Sue A.\} and John, \{Esther M.\} and Hayes, \{Richard B.\} and Pharoah, \{Paul D.P.\} and Nora Pashayan and Khaw, \{Kay Tee\} and Stanford, \{Janet L.\} and Ostrander, \{Elaine A.\} and Signorello, \{Lisa B.\} and Thibodeau, \{Stephen N.\} and Dan Schaid and Christiane Maier and Walther Vogel and Kibel, \{Adam S.\} and Cezary Cybulski and Jan Lubinski and Lisa Cannon-Albright and Hermann Brenner and Park, \{Jong Y.\} and Radka Kaneva and Jyotsna Batra and Spurdle, \{Amanda B.\} and Clements, \{Judith A.\} and Teixeira, \{Manuel R.\} and Ed Dicks and Andrew Lee and Dunning, \{Alison M.\} and Caroline Baynes and Don Conroy and Maranian, \{Melanie J.\} and Shahana Ahmed and Koveela Govindasami and Michelle Guy and Wilkinson, \{Rosemary A.\} and Sawyer, \{Emma J.\} and Angela Morgan and Dearnaley, \{David P.\} and Alan Horwich and Huddart, \{Robert A.\} and Khoo, \{Vincent S.\} and Parker, \{Christopher C.\} and \{Van As\}, \{Nicholas J.\} and Woodhouse, \{Christopher J.\} and Alan Thompson and Tim Dudderidge and Chris Ogden and Cooper, \{Colin S.\} and Artitaya Lophatananon and Angela Cox and Southey, \{Melissa C.\} and Hopper, \{John L.\} and English, \{Dallas R.\} and Markus Aly and Jan Adolfsson and Jiangfeng Xu and Zheng, \{Siqun L.\} and Meredith Yeager and Rudolf Kaaks and Diver, \{W. Ryan\} and Gaudet, \{Mia M.\} and Stern, \{Mariana C.\} and Roman Corral",

year = "2013",

month = mar,

day = "27",

doi = "10.1038/ng.2560",

language = "English",

volume = "45",

pages = "385--391",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "4",

}

Eeles, RA, Olama, AAA, Benlloch, S, Saunders, EJ, Leongamornlert, DA, Tymrakiewicz, M, Ghoussaini, M, Luccarini, C, Dennis, J, Jugurnauth-Little, S, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium & Batra, J 2013, 'Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array', Nature Genetics, vol. 45, no. 4, pp. 385-391. https://doi.org/10.1038/ng.2560

TY - JOUR

T1 - Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

AU - Eeles, Rosalind A.

AU - Olama, Ali Amin Al

AU - Benlloch, Sara

AU - Saunders, Edward J.

AU - Leongamornlert, Daniel A.

AU - Tymrakiewicz, Malgorzata

AU - Ghoussaini, Maya

AU - Luccarini, Craig

AU - Dennis, Joe

AU - Jugurnauth-Little, Sarah

AU - The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium

AU - Dadaev, Tokhir

AU - Neal, David E.

AU - Hamdy, Freddie C.

AU - Donovan, Jenny L.

AU - Muir, Ken

AU - Giles, Graham G.

AU - Severi, Gianluca

AU - Wiklund, Fredrik

AU - Gronberg, Henrik

AU - Haiman, Christopher A.

AU - Schumacher, Fredrick

AU - Henderson, Brian E.

AU - Le Marchand, Loic

AU - Lindstrom, Sara

AU - Kraft, Peter

AU - Hunter, David J.

AU - Gapstur, Susan

AU - Chanock, Stephen J.

AU - Berndt, Sonja I.

AU - Albanes, Demetrius

AU - Andriole, Gerald

AU - Schleutker, Johanna

AU - Weischer, Maren

AU - Canzian, Federico

AU - Riboli, Elio

AU - Key, Tim J.

AU - Travis, Ruth C.

AU - Campa, Daniele

AU - Ingles, Sue A.

AU - John, Esther M.

AU - Hayes, Richard B.

AU - Pharoah, Paul D.P.

AU - Pashayan, Nora

AU - Khaw, Kay Tee

AU - Stanford, Janet L.

AU - Ostrander, Elaine A.

AU - Signorello, Lisa B.

AU - Thibodeau, Stephen N.

AU - Schaid, Dan

AU - Maier, Christiane

AU - Vogel, Walther

AU - Kibel, Adam S.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Park, Jong Y.

AU - Kaneva, Radka

AU - Batra, Jyotsna

AU - Spurdle, Amanda B.

AU - Clements, Judith A.

AU - Teixeira, Manuel R.

AU - Dicks, Ed

AU - Lee, Andrew

AU - Dunning, Alison M.

AU - Baynes, Caroline

AU - Conroy, Don

AU - Maranian, Melanie J.

AU - Ahmed, Shahana

AU - Govindasami, Koveela

AU - Guy, Michelle

AU - Wilkinson, Rosemary A.

AU - Sawyer, Emma J.

AU - Morgan, Angela

AU - Dearnaley, David P.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Van As, Nicholas J.

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Dudderidge, Tim

AU - Ogden, Chris

AU - Cooper, Colin S.

AU - Lophatananon, Artitaya

AU - Cox, Angela

AU - Southey, Melissa C.

AU - Hopper, John L.

AU - English, Dallas R.

AU - Aly, Markus

AU - Adolfsson, Jan

AU - Xu, Jiangfeng

AU - Zheng, Siqun L.

AU - Yeager, Meredith

AU - Kaaks, Rudolf

AU - Diver, W. Ryan

AU - Gaudet, Mia M.

AU - Stern, Mariana C.

AU - Corral, Roman

PY - 2013/3/27

Y1 - 2013/3/27

N2 - Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

AB - Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

UR - https://www.scopus.com/pages/publications/84875739291

U2 - 10.1038/ng.2560

DO - 10.1038/ng.2560

M3 - Article

C2 - 23535732

AN - SCOPUS:84875739291

SN - 1061-4036

VL - 45

SP - 385

EP - 391

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

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