Hypothalamus-pituitary-adrenal axis daily fluctuation, anxiety and age interact to predict cortisol concentrations in boys with an autism spectrum disorder

Vicki Bitsika, Christopher F. Sharpley, Nicholas M. Andronicos, Linda L. Agnew

    Research output: Contribution to journalArticleResearchpeer-review

    22 Citations (Scopus)

    Abstract

    There is considerable evidence of a confound between symptoms of generalised anxiety disorder (GAD) and autism spectrum disorder (ASD) in children who have an ASD. Although there have been several attempts to describe how these two disorders overlap and interact to influence the assessment and diagnosis of children with an ASD, principally by reference to cortisol assayed from these children's saliva, the overall evidence is inconsistent. Because previous models of these relationships have focused upon cortisol and GAD to the exclusion of age, diurnal fluctuation in the HPA axis and the source of GAD data, these variables were examined in a sample of 150 young males with an ASD. Results indicated that there was a significant interaction between these variables, with the association between GAD and cortisol demonstrated for children but not for adolescents, with an interaction between the source of GAD information (self- vs parent-ratings) and whether the child's cortisol concentrations followed the expected diurnal reduction during the day. These data suggest that the validity of cortisol as a biomarker of GAD in children and adolescents with an ASD may be established for only selected subgroups of this population.

    Original languageEnglish
    Pages (from-to)200-207
    Number of pages8
    JournalPhysiology and Behavior
    Volume138
    DOIs
    Publication statusPublished - 1 Jan 2015

    Fingerprint

    Anxiety Disorders
    Hypothalamus
    Hydrocortisone
    Anxiety
    Saliva
    Autism Spectrum Disorder
    Fluctuations
    Autism Spectrum Disorders
    Boys
    Cortisol
    Biomarkers
    Population

    Cite this

    Bitsika, Vicki ; Sharpley, Christopher F. ; Andronicos, Nicholas M. ; Agnew, Linda L. / Hypothalamus-pituitary-adrenal axis daily fluctuation, anxiety and age interact to predict cortisol concentrations in boys with an autism spectrum disorder. In: Physiology and Behavior. 2015 ; Vol. 138. pp. 200-207.
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    abstract = "There is considerable evidence of a confound between symptoms of generalised anxiety disorder (GAD) and autism spectrum disorder (ASD) in children who have an ASD. Although there have been several attempts to describe how these two disorders overlap and interact to influence the assessment and diagnosis of children with an ASD, principally by reference to cortisol assayed from these children's saliva, the overall evidence is inconsistent. Because previous models of these relationships have focused upon cortisol and GAD to the exclusion of age, diurnal fluctuation in the HPA axis and the source of GAD data, these variables were examined in a sample of 150 young males with an ASD. Results indicated that there was a significant interaction between these variables, with the association between GAD and cortisol demonstrated for children but not for adolescents, with an interaction between the source of GAD information (self- vs parent-ratings) and whether the child's cortisol concentrations followed the expected diurnal reduction during the day. These data suggest that the validity of cortisol as a biomarker of GAD in children and adolescents with an ASD may be established for only selected subgroups of this population.",
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    Hypothalamus-pituitary-adrenal axis daily fluctuation, anxiety and age interact to predict cortisol concentrations in boys with an autism spectrum disorder. / Bitsika, Vicki; Sharpley, Christopher F.; Andronicos, Nicholas M.; Agnew, Linda L.

    In: Physiology and Behavior, Vol. 138, 01.01.2015, p. 200-207.

    Research output: Contribution to journalArticleResearchpeer-review

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