Hypothalamus-pituitary-adrenal-axis associations with self- vs. parental ratings of depression in boys with an autism spectrum disorder

Vicki Bitsika, Christopher F. Sharpley, Nicholas M. Andronicos, Linda L. Agnew

    Research output: Contribution to journalArticleResearchpeer-review

    1 Citation (Scopus)

    Abstract

    Background: Depression can be a major comorbidity in young people with an autism spectrum disorder (ASD). Although there is an association between major depressive disorder (MDD) and cortisol concentrations in non-ASD children, relatively little is known about that relationship in children with an ASD, or whether there are development effects on the relationship. It is also unclear whether self-reports or parents' reports of depression in these children are more closely associated with cortisol. Methods: Salivary cortisol from morning and afternoon, plus Child and Adolescent Symptom Inventory responses for MDD, were collected from a sample of 139 boys with an ASD. Parents of these boys also provided ratings of their sons on the Child and Adolescent Symptom Inventory for MDD. Results: Afternoon cortisol was significantly correlated with total depression scores for younger boys but not for older boys. There were also significant differences between the parents' and the boys' ratings for five of the 10 MDD symptoms. Parents' ratings of their sons' MDD symptoms of irritability, feeling sad or depressed, and sleeping problems were significantly correlated with the boys' cortisol concentrations. Both boys' and their parents' ratings for thoughts of death, feeling worthless, and concentration problems were significantly associated with the boys' cortisol concentrations. Conclusion: A reliable assessment of MDD in young people with an ASD requires careful consideration of the relative validity of parents' and children's reports of the latter's individual MDD symptomatology.

    Original languageEnglish
    Pages (from-to)69-75
    Number of pages7
    JournalInternational Journal on Disability and Human Development
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 1 Feb 2016

    Fingerprint

    Major Depressive Disorder
    Hypothalamus
    Depression
    Hydrocortisone
    Parents
    Nuclear Family
    Emotions
    Equipment and Supplies
    Autism Spectrum Disorder
    Self Report
    Comorbidity

    Cite this

    Bitsika, Vicki ; Sharpley, Christopher F. ; Andronicos, Nicholas M. ; Agnew, Linda L. / Hypothalamus-pituitary-adrenal-axis associations with self- vs. parental ratings of depression in boys with an autism spectrum disorder. In: International Journal on Disability and Human Development. 2016 ; Vol. 15, No. 1. pp. 69-75.
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    abstract = "Background: Depression can be a major comorbidity in young people with an autism spectrum disorder (ASD). Although there is an association between major depressive disorder (MDD) and cortisol concentrations in non-ASD children, relatively little is known about that relationship in children with an ASD, or whether there are development effects on the relationship. It is also unclear whether self-reports or parents' reports of depression in these children are more closely associated with cortisol. Methods: Salivary cortisol from morning and afternoon, plus Child and Adolescent Symptom Inventory responses for MDD, were collected from a sample of 139 boys with an ASD. Parents of these boys also provided ratings of their sons on the Child and Adolescent Symptom Inventory for MDD. Results: Afternoon cortisol was significantly correlated with total depression scores for younger boys but not for older boys. There were also significant differences between the parents' and the boys' ratings for five of the 10 MDD symptoms. Parents' ratings of their sons' MDD symptoms of irritability, feeling sad or depressed, and sleeping problems were significantly correlated with the boys' cortisol concentrations. Both boys' and their parents' ratings for thoughts of death, feeling worthless, and concentration problems were significantly associated with the boys' cortisol concentrations. Conclusion: A reliable assessment of MDD in young people with an ASD requires careful consideration of the relative validity of parents' and children's reports of the latter's individual MDD symptomatology.",
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    Hypothalamus-pituitary-adrenal-axis associations with self- vs. parental ratings of depression in boys with an autism spectrum disorder. / Bitsika, Vicki; Sharpley, Christopher F.; Andronicos, Nicholas M.; Agnew, Linda L.

    In: International Journal on Disability and Human Development, Vol. 15, No. 1, 01.02.2016, p. 69-75.

    Research output: Contribution to journalArticleResearchpeer-review

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