Hypercortisolaemia and neurobiological structural alterations during depression: How do current treatments fit?

Christopher F. Sharpley

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


Although several treatment options exist for mild, moderate and severe depression, few reports have closely linked the sequence of neuroendocrinal and regional brain structural and connectivity alterations which accompany depression with the therapeutic processes underlying a range of common treatments. By examining the neurobiological correlates of depression (particularly Major Depressive Disorder), and then discussing the underlying causal mechanisms of common treatments, this review suggests that only tangential links may be found between these two sets of variables.

Original languageEnglish
Pages (from-to)104-115
Number of pages12
JournalGerman Journal of Psychiatry
Issue number2
Publication statusPublished - 2010
Externally publishedYes


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