How do detrusor responses to clinical antimuscarinic medications vary between differently aged porcine bladders?

Antimuscarinics are the first line medications for overactive bladder (OAB) patients, with a mechanism involving the inhibition of detrusor spontaneous contractions during the filling phase. However, 70% of OAB patients discontinue their antimuscarinic treatments due to lower-than-expected treatment benefits or adverse side effects. With an increasing prevalence of OAB with age, there is a benefit to identifying whether the influence of antimuscarinics on bladder tissue alters due to ageing.3 This study aims to find the variations in the ability of common clinical antimuscarinics to inhibit contractions of the detrusor and compare these responses in juvenile and adult porcine tissues.