Homocysteine Levels in Neurological Disorders

Ahmed A. Moustafa; Doaa H. Hewedi; Abeer M. Eissa; Dorota Frydecka; Błazej Misiak

doi:10.1002/9781118840634.ch7

Homocysteine Levels in Neurological Disorders

Ahmed A. Moustafa^*, Doaa H. Hewedi, Abeer M. Eissa, Dorota Frydecka, Błazej Misiak

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

7 Citations (Scopus)

Abstract

The chapter reviews prior data on the relationship between homocysteine (Hcy) levels and cognitive function (such as learning, memory, and attentional processes) in various neurological disorders, including (but not limited to) mild cognitive impairment (MCI), vascular dementia, Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), as well as fibromyalgia and chronic fatigue syndrome. Specifically, we will review data showing how hyperhomocysteinemia (i.e., abnormal increase in Hcy levels) contributes to various neurological disorders. We also review prior studies showing the relationship between Hcy levels and different symptoms of MCI and AD. Further, we will discuss the neural substrates underlying the effects of Hcy levels on the brain, behavior, and cognition. Some of these brain structures include the hippocampus, cortex, as well as neurotransmitters (including acetylcholine and dopamine).

Original language	English
Title of host publication	Diet and Exercise in Cognitive Function and Neurological Diseases
Editors	Tahira Farooqui, Akhlaq A Farooqui
Publisher	Wiley-Blackwell
Chapter	7
Pages	73-81
Number of pages	9
ISBN (Electronic)	9781118840634
ISBN (Print)	9781118840559
DOIs	https://doi.org/10.1002/9781118840634.ch7
Publication status	Published - 6 Feb 2015
Externally published	Yes

Access to Document

10.1002/9781118840634.ch7

Cite this

@inbook{f52b39cf570440cea40a59e19033ebaa,

title = "Homocysteine Levels in Neurological Disorders",

abstract = "The chapter reviews prior data on the relationship between homocysteine (Hcy) levels and cognitive function (such as learning, memory, and attentional processes) in various neurological disorders, including (but not limited to) mild cognitive impairment (MCI), vascular dementia, Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), as well as fibromyalgia and chronic fatigue syndrome. Specifically, we will review data showing how hyperhomocysteinemia (i.e., abnormal increase in Hcy levels) contributes to various neurological disorders. We also review prior studies showing the relationship between Hcy levels and different symptoms of MCI and AD. Further, we will discuss the neural substrates underlying the effects of Hcy levels on the brain, behavior, and cognition. Some of these brain structures include the hippocampus, cortex, as well as neurotransmitters (including acetylcholine and dopamine).",

author = "Moustafa, {Ahmed A.} and Hewedi, {Doaa H.} and Eissa, {Abeer M.} and Dorota Frydecka and B{\l}azej Misiak",

year = "2015",

month = feb,

day = "6",

doi = "10.1002/9781118840634.ch7",

language = "English",

isbn = "9781118840559",

pages = "73--81",

editor = "Tahira Farooqui and Farooqui, {Akhlaq A}",

booktitle = "Diet and Exercise in Cognitive Function and Neurological Diseases",

publisher = "Wiley-Blackwell",

address = "United Kingdom",

}

TY - CHAP

T1 - Homocysteine Levels in Neurological Disorders

AU - Moustafa, Ahmed A.

AU - Hewedi, Doaa H.

AU - Eissa, Abeer M.

AU - Frydecka, Dorota

AU - Misiak, Błazej

PY - 2015/2/6

Y1 - 2015/2/6

N2 - The chapter reviews prior data on the relationship between homocysteine (Hcy) levels and cognitive function (such as learning, memory, and attentional processes) in various neurological disorders, including (but not limited to) mild cognitive impairment (MCI), vascular dementia, Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), as well as fibromyalgia and chronic fatigue syndrome. Specifically, we will review data showing how hyperhomocysteinemia (i.e., abnormal increase in Hcy levels) contributes to various neurological disorders. We also review prior studies showing the relationship between Hcy levels and different symptoms of MCI and AD. Further, we will discuss the neural substrates underlying the effects of Hcy levels on the brain, behavior, and cognition. Some of these brain structures include the hippocampus, cortex, as well as neurotransmitters (including acetylcholine and dopamine).

AB - The chapter reviews prior data on the relationship between homocysteine (Hcy) levels and cognitive function (such as learning, memory, and attentional processes) in various neurological disorders, including (but not limited to) mild cognitive impairment (MCI), vascular dementia, Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), as well as fibromyalgia and chronic fatigue syndrome. Specifically, we will review data showing how hyperhomocysteinemia (i.e., abnormal increase in Hcy levels) contributes to various neurological disorders. We also review prior studies showing the relationship between Hcy levels and different symptoms of MCI and AD. Further, we will discuss the neural substrates underlying the effects of Hcy levels on the brain, behavior, and cognition. Some of these brain structures include the hippocampus, cortex, as well as neurotransmitters (including acetylcholine and dopamine).

UR - http://www.scopus.com/inward/record.url?scp=85016347262&partnerID=8YFLogxK

U2 - 10.1002/9781118840634.ch7

DO - 10.1002/9781118840634.ch7

M3 - Chapter

AN - SCOPUS:85016347262

SN - 9781118840559

SP - 73

EP - 81

BT - Diet and Exercise in Cognitive Function and Neurological Diseases

A2 - Farooqui, Tahira

A2 - Farooqui, Akhlaq A

PB - Wiley-Blackwell

ER -

Homocysteine Levels in Neurological Disorders

Abstract

Access to Document

Other files and links

Fingerprint

Cite this