Homocysteine Levels in Neurological Disorders

Ahmed A. Moustafa*, Doaa H. Hewedi, Abeer M. Eissa, Dorota Frydecka, Błazej Misiak

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

7 Citations (Scopus)


The chapter reviews prior data on the relationship between homocysteine (Hcy) levels and cognitive function (such as learning, memory, and attentional processes) in various neurological disorders, including (but not limited to) mild cognitive impairment (MCI), vascular dementia, Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), as well as fibromyalgia and chronic fatigue syndrome. Specifically, we will review data showing how hyperhomocysteinemia (i.e., abnormal increase in Hcy levels) contributes to various neurological disorders. We also review prior studies showing the relationship between Hcy levels and different symptoms of MCI and AD. Further, we will discuss the neural substrates underlying the effects of Hcy levels on the brain, behavior, and cognition. Some of these brain structures include the hippocampus, cortex, as well as neurotransmitters (including acetylcholine and dopamine).

Original languageEnglish
Title of host publicationDiet and Exercise in Cognitive Function and Neurological Diseases
EditorsTahira Farooqui, Akhlaq A Farooqui
Number of pages9
ISBN (Electronic)9781118840634
ISBN (Print)9781118840559
Publication statusPublished - 6 Feb 2015
Externally publishedYes


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