Herb-drug interactions: An evidence based approach

P. D. Coxeter, Andrew J McLachlan, C. C. Duke, B. D. Roufogalis

Research output: Contribution to journalReview articleResearchpeer-review

64 Citations (Scopus)


The increasing use of herbal medicinal products (HMPs) in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be of significant public health consequence. The evidence available to guide practitioners in decision making is complex and consists of a range of sources including adverse event database entries, spontaneous or case reports, in vivo and in vitro drug metabolism studies, and in vivo drug interaction studies in healthy subjects and patients. In the absence of further rigorous studies to assess the clinical significance of herb-drug interactions, an evidence-based appraisal of the current literature is essential to guide practitioners involved in patient care.

Original languageEnglish
Pages (from-to)1513-1525
Number of pages13
JournalCurrent Medicinal Chemistry
Issue number11
Publication statusPublished - Jun 2004
Externally publishedYes


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