TY - JOUR
T1 - Hepatocyte nuclear factor 1 beta: A perspective in cancer
AU - Chandra, Shubhra
AU - Srinivasan, Srilakshmi
AU - Batra, Jyotsna
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Hepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity-onset diabetes of the young (MODY), HNF1β expression deregulation and single nucleotide polymorphisms in HNF1β have now been associated with several tumours including endometrial, prostate, ovarian, hepatocellular, renal and colorectal cancers. Its function has been studied either as homodimer or heterodimer with HNF1α. In this review, the role of HNF1B in different cancers will be discussed along with the role of its splice variants, and its emerging role as a potential biomarker in cancer.
AB - Hepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity-onset diabetes of the young (MODY), HNF1β expression deregulation and single nucleotide polymorphisms in HNF1β have now been associated with several tumours including endometrial, prostate, ovarian, hepatocellular, renal and colorectal cancers. Its function has been studied either as homodimer or heterodimer with HNF1α. In this review, the role of HNF1B in different cancers will be discussed along with the role of its splice variants, and its emerging role as a potential biomarker in cancer.
UR - http://www.scopus.com/inward/record.url?scp=85101440043&partnerID=8YFLogxK
U2 - 10.1002/cam4.3676
DO - 10.1002/cam4.3676
M3 - Review article
C2 - 33580750
AN - SCOPUS:85101440043
SN - 2045-7634
VL - 10
SP - 1791
EP - 1804
JO - Cancer Medicine
JF - Cancer Medicine
IS - 5
ER -
