Heart rate variability is related to impaired haemorheology in older women with type 2 diabetes

Michael J. Simmonds, Surendran Sabapathy, Gregory C. Gass, Sonya M. Marshall-Gradisnik, Luke J. Haseler, Rhys M. Christy, Clare L. Minahan

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Abstract

Impaired heart rate variability (HRV)and haemorheology are independently associated with cardiovascular disease and diabetic complications. The aim of the present study was to investigate the relationships between parameters of HRV,and red blood cell (RBC) aggregation and deformability, in older women with type 2 diabetes. Twenty women (age 69 ± 2 yr) with uncomplicated type 2 diabetes and twenty controls (age 69 ± 3 yr) participated in the study. Beat-to-beat cardiac (RR) intervals over 5 min were analysed for HRV parameters in the time and frequency domains. Blood was sampled for RBC deformability, as well as RBC aggregation in two suspending mediums: haematocrit adjusted plasma and 3% dextran 70. RBC aggregation was increased and HRV was impaired for those with type 2 diabetes when compared with control. RBC aggregation was negatively related to low frequency power of HRV, and was positively related to high frequency power of HRV, for subjects with type 2 diabetes. RBC deformability was positively related to HRV only for those with type 2 diabetes. Impaired haemorheology is associated with reduced HRV in older women with type 2 diabetes, suggesting changes in the microcirculation may result in impaired modulation of cardiac cycles.

Original languageEnglish
Pages (from-to)57-68
Number of pages12
JournalClinical Hemorheology and Microcirculation
Volume46
Issue number1
DOIs
Publication statusPublished - 2010

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Hemorheology
Type 2 Diabetes Mellitus
Heart Rate
Cell Aggregation
Erythrocytes
Diabetes Complications
Microcirculation
Dextrans
Hematocrit
Cardiovascular Diseases

Cite this

Simmonds, M. J., Sabapathy, S., Gass, G. C., Marshall-Gradisnik, S. M., Haseler, L. J., Christy, R. M., & Minahan, C. L. (2010). Heart rate variability is related to impaired haemorheology in older women with type 2 diabetes. Clinical Hemorheology and Microcirculation, 46(1), 57-68. https://doi.org/10.3233/CH-2010-1333
Simmonds, Michael J. ; Sabapathy, Surendran ; Gass, Gregory C. ; Marshall-Gradisnik, Sonya M. ; Haseler, Luke J. ; Christy, Rhys M. ; Minahan, Clare L. / Heart rate variability is related to impaired haemorheology in older women with type 2 diabetes. In: Clinical Hemorheology and Microcirculation. 2010 ; Vol. 46, No. 1. pp. 57-68.
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Simmonds, MJ, Sabapathy, S, Gass, GC, Marshall-Gradisnik, SM, Haseler, LJ, Christy, RM & Minahan, CL 2010, 'Heart rate variability is related to impaired haemorheology in older women with type 2 diabetes' Clinical Hemorheology and Microcirculation, vol. 46, no. 1, pp. 57-68. https://doi.org/10.3233/CH-2010-1333

Heart rate variability is related to impaired haemorheology in older women with type 2 diabetes. / Simmonds, Michael J.; Sabapathy, Surendran; Gass, Gregory C.; Marshall-Gradisnik, Sonya M.; Haseler, Luke J.; Christy, Rhys M.; Minahan, Clare L.

In: Clinical Hemorheology and Microcirculation, Vol. 46, No. 1, 2010, p. 57-68.

Research output: Contribution to journalArticleResearchpeer-review

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