H-2U: A new region at the D end of the murine MHC

H C O'Neill, C R Parish

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

A new genetic region, mapping within the H-2 complex, has been serologically defined with several alloantisera raised in mice which differ at the D region. When these antisera were absorbed to remove H-2D antibodies, residual antibody activity remained that reacted in a strain-specific manner, and the antigens involved mapped to a new genetic region between the S and D regions. Two allelic variants relating to the d and k haplotypes have been defined by genetic mapping studies. This new region has been designated H-2U and the antigens it controls appear to resemble Ia antigens in their cellular distribution and molecular weight. The new antigen is primarily expressed on B cells, and is carried on protein molecules having approximate molecular weights of 36 000 and 60 000 daltons and resembling the alpha and alpha--beta chain dimer characteristic of Ia antigens.

Original languageEnglish
Pages (from-to)247-59
Number of pages13
JournalImmunogenetics
Volume13
Issue number3
DOIs
Publication statusPublished - May 1981
Externally publishedYes

Fingerprint

Histocompatibility Antigens Class II
Molecular Weight
Antigens
Antibodies
Haplotypes
Immune Sera
B-Lymphocytes
Proteins
H antigen

Cite this

O'Neill, H C ; Parish, C R. / H-2U : A new region at the D end of the murine MHC. In: Immunogenetics. 1981 ; Vol. 13, No. 3. pp. 247-59.
@article{661b26a53c6044708692b7e9e07f5d4e,
title = "H-2U: A new region at the D end of the murine MHC",
abstract = "A new genetic region, mapping within the H-2 complex, has been serologically defined with several alloantisera raised in mice which differ at the D region. When these antisera were absorbed to remove H-2D antibodies, residual antibody activity remained that reacted in a strain-specific manner, and the antigens involved mapped to a new genetic region between the S and D regions. Two allelic variants relating to the d and k haplotypes have been defined by genetic mapping studies. This new region has been designated H-2U and the antigens it controls appear to resemble Ia antigens in their cellular distribution and molecular weight. The new antigen is primarily expressed on B cells, and is carried on protein molecules having approximate molecular weights of 36 000 and 60 000 daltons and resembling the alpha and alpha--beta chain dimer characteristic of Ia antigens.",
author = "O'Neill, {H C} and Parish, {C R}",
year = "1981",
month = "5",
doi = "10.1007/BF00350791",
language = "English",
volume = "13",
pages = "247--59",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer",
number = "3",

}

H-2U : A new region at the D end of the murine MHC. / O'Neill, H C; Parish, C R.

In: Immunogenetics, Vol. 13, No. 3, 05.1981, p. 247-59.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - H-2U

T2 - A new region at the D end of the murine MHC

AU - O'Neill, H C

AU - Parish, C R

PY - 1981/5

Y1 - 1981/5

N2 - A new genetic region, mapping within the H-2 complex, has been serologically defined with several alloantisera raised in mice which differ at the D region. When these antisera were absorbed to remove H-2D antibodies, residual antibody activity remained that reacted in a strain-specific manner, and the antigens involved mapped to a new genetic region between the S and D regions. Two allelic variants relating to the d and k haplotypes have been defined by genetic mapping studies. This new region has been designated H-2U and the antigens it controls appear to resemble Ia antigens in their cellular distribution and molecular weight. The new antigen is primarily expressed on B cells, and is carried on protein molecules having approximate molecular weights of 36 000 and 60 000 daltons and resembling the alpha and alpha--beta chain dimer characteristic of Ia antigens.

AB - A new genetic region, mapping within the H-2 complex, has been serologically defined with several alloantisera raised in mice which differ at the D region. When these antisera were absorbed to remove H-2D antibodies, residual antibody activity remained that reacted in a strain-specific manner, and the antigens involved mapped to a new genetic region between the S and D regions. Two allelic variants relating to the d and k haplotypes have been defined by genetic mapping studies. This new region has been designated H-2U and the antigens it controls appear to resemble Ia antigens in their cellular distribution and molecular weight. The new antigen is primarily expressed on B cells, and is carried on protein molecules having approximate molecular weights of 36 000 and 60 000 daltons and resembling the alpha and alpha--beta chain dimer characteristic of Ia antigens.

U2 - 10.1007/BF00350791

DO - 10.1007/BF00350791

M3 - Article

VL - 13

SP - 247

EP - 259

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 3

ER -