Growth regulation of a T-cell lymphoma via the T-cell receptor

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Autocrine stimulation is described for a Radiation leukaemia virus (RadLV)-induced T-cell lymphoma, C6VL/1. The proliferation of this tumour cell line can be regulated by several agents, including interleukin-2 (IL-2), antibodies to the IL-2 receptor and the T-cell antigen-specific receptor (TCR), as well as RadLV retrovirus particles produced by the cell itself. This information has been gained using various procedures to slow or arrest C6VL/1 proliferation, including the addition of gamma interferon (gamma-IFN) and cell culture at low density. All data suggest that these cells can receive growth stimulation via the T-cell receptor (TCR) and IL-2 receptor, implicating autocrine stimulation of growth involving IL-2 and retroviral gene products.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalLeukemia Research
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1994
Externally publishedYes

Fingerprint

T-Cell Lymphoma
Radiation Leukemia Virus
T-Cell Antigen Receptor
Interleukin-2 Receptors
Interleukin-2
Growth
Retroviridae
Tumor Cell Line
Virion
Interferon-gamma
Cell Culture Techniques
Antibodies
Genes

Cite this

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title = "Growth regulation of a T-cell lymphoma via the T-cell receptor",
abstract = "Autocrine stimulation is described for a Radiation leukaemia virus (RadLV)-induced T-cell lymphoma, C6VL/1. The proliferation of this tumour cell line can be regulated by several agents, including interleukin-2 (IL-2), antibodies to the IL-2 receptor and the T-cell antigen-specific receptor (TCR), as well as RadLV retrovirus particles produced by the cell itself. This information has been gained using various procedures to slow or arrest C6VL/1 proliferation, including the addition of gamma interferon (gamma-IFN) and cell culture at low density. All data suggest that these cells can receive growth stimulation via the T-cell receptor (TCR) and IL-2 receptor, implicating autocrine stimulation of growth involving IL-2 and retroviral gene products.",
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Growth regulation of a T-cell lymphoma via the T-cell receptor. / O'Neill, H C.

In: Leukemia Research, Vol. 18, No. 1, 01.1994, p. 23-28.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

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AU - O'Neill, H C

PY - 1994/1

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AB - Autocrine stimulation is described for a Radiation leukaemia virus (RadLV)-induced T-cell lymphoma, C6VL/1. The proliferation of this tumour cell line can be regulated by several agents, including interleukin-2 (IL-2), antibodies to the IL-2 receptor and the T-cell antigen-specific receptor (TCR), as well as RadLV retrovirus particles produced by the cell itself. This information has been gained using various procedures to slow or arrest C6VL/1 proliferation, including the addition of gamma interferon (gamma-IFN) and cell culture at low density. All data suggest that these cells can receive growth stimulation via the T-cell receptor (TCR) and IL-2 receptor, implicating autocrine stimulation of growth involving IL-2 and retroviral gene products.

U2 - 10.1016/0145-2126(94)90005-1

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