TY - JOUR
T1 - GRADE guidelines
T2 - 2. Framing the question and deciding on important outcomes
AU - Guyatt, Gordon H.
AU - Oxman, Andrew D.
AU - Kunz, Regina
AU - Atkins, David
AU - Brozek, Jan
AU - Vist, Gunn
AU - Alderson, Philip
AU - Glasziou, Paul
AU - Falck-Ytter, Yngve
AU - Schünemann, Holger J.
PY - 2011/4
Y1 - 2011/4
N2 - GRADE requires a clear specification of the relevant setting, population, intervention, and comparator. It also requires specification of all important outcomes - whether evidence from research studies is, or is not, available. For a particular management question, the population, intervention, and outcome should be sufficiently similar across studies that a similar magnitude of effect is plausible. Guideline developers should specify the relative importance of the outcomes before gathering the evidence and again when evidence summaries are complete. In considering the importance of a surrogate outcome, authors should rate the importance of the patient-important outcome for which the surrogate is a substitute and subsequently rate down the quality of evidence for indirectness of outcome.
AB - GRADE requires a clear specification of the relevant setting, population, intervention, and comparator. It also requires specification of all important outcomes - whether evidence from research studies is, or is not, available. For a particular management question, the population, intervention, and outcome should be sufficiently similar across studies that a similar magnitude of effect is plausible. Guideline developers should specify the relative importance of the outcomes before gathering the evidence and again when evidence summaries are complete. In considering the importance of a surrogate outcome, authors should rate the importance of the patient-important outcome for which the surrogate is a substitute and subsequently rate down the quality of evidence for indirectness of outcome.
UR - http://www.scopus.com/inward/record.url?scp=79951951792&partnerID=8YFLogxK
U2 - 10.1016/j.jclinepi.2010.09.012
DO - 10.1016/j.jclinepi.2010.09.012
M3 - Review article
C2 - 21194891
AN - SCOPUS:79951951792
SN - 0895-4356
VL - 64
SP - 395
EP - 400
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 4
ER -