Glutamate transport modulation: A possible role in retinal neuroprotection

Nigel L. Barnett; Kei Takamoto; Natalie D. Bull

doi:10.1007/0-387-32442-9_46

Glutamate transport modulation: A possible role in retinal neuroprotection

Nigel L. Barnett, Kei Takamoto, Natalie D. Bull

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

1 Citation (Scopus)

Abstract

The regulation of extracellular glutamate levels in the retina, under physiological and pathophysiological conditions, is essential for the prevention of excitotoxic neurodegeneration. Glial and neuronal high-affinity glutamate transporters (excitatory amino acid transporters, EAATs) facilitate the rapid removal of glutamate from the extracellular space, thereby terminating the excitatory signal and reducing the possibility of excitotoxic neuronal damage. Failure or reversal of these transport systems leads to raised levels of extracellular glutamate and contributes to the development of excitotoxic retinal degeneration.

Original language	English
Title of host publication	Retinal Degenerative Diseases
Editors	Joe G. Hollyfield, Robert E. Anderson, Matthew M. LaVail
Place of Publication	Boston
Publisher	Springer
Pages	327-332
Number of pages	6
ISBN (Electronic)	978-0-387-32442-5
ISBN (Print)	978-0-387-28464-4
DOIs	https://doi.org/10.1007/0-387-32442-9_46
Publication status	Published - 2006
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Publisher	Springer
Volume	572
ISSN (Print)	0065-2598

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10.1007/0-387-32442-9_46

Cite this

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title = "Glutamate transport modulation: A possible role in retinal neuroprotection",

abstract = "The regulation of extracellular glutamate levels in the retina, under physiological and pathophysiological conditions, is essential for the prevention of excitotoxic neurodegeneration. Glial and neuronal high-affinity glutamate transporters (excitatory amino acid transporters, EAATs) facilitate the rapid removal of glutamate from the extracellular space, thereby terminating the excitatory signal and reducing the possibility of excitotoxic neuronal damage. Failure or reversal of these transport systems leads to raised levels of extracellular glutamate and contributes to the development of excitotoxic retinal degeneration.",

author = "Barnett, {Nigel L.} and Kei Takamoto and Bull, {Natalie D.}",

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Glutamate transport modulation: A possible role in retinal neuroprotection. / Barnett, Nigel L.; Takamoto, Kei; Bull, Natalie D.
Retinal Degenerative Diseases. ed. / Joe G. Hollyfield; Robert E. Anderson; Matthew M. LaVail. Boston: Springer, 2006. p. 327-332 (Advances in Experimental Medicine and Biology; Vol. 572).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

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AU - Barnett, Nigel L.

AU - Takamoto, Kei

AU - Bull, Natalie D.

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N2 - The regulation of extracellular glutamate levels in the retina, under physiological and pathophysiological conditions, is essential for the prevention of excitotoxic neurodegeneration. Glial and neuronal high-affinity glutamate transporters (excitatory amino acid transporters, EAATs) facilitate the rapid removal of glutamate from the extracellular space, thereby terminating the excitatory signal and reducing the possibility of excitotoxic neuronal damage. Failure or reversal of these transport systems leads to raised levels of extracellular glutamate and contributes to the development of excitotoxic retinal degeneration.

AB - The regulation of extracellular glutamate levels in the retina, under physiological and pathophysiological conditions, is essential for the prevention of excitotoxic neurodegeneration. Glial and neuronal high-affinity glutamate transporters (excitatory amino acid transporters, EAATs) facilitate the rapid removal of glutamate from the extracellular space, thereby terminating the excitatory signal and reducing the possibility of excitotoxic neuronal damage. Failure or reversal of these transport systems leads to raised levels of extracellular glutamate and contributes to the development of excitotoxic retinal degeneration.

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SN - 978-0-387-28464-4

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A2 - Anderson, Robert E.

A2 - LaVail, Matthew M.

PB - Springer

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ER -

Glutamate transport modulation: A possible role in retinal neuroprotection

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Assessing the efficacy of gene therapy in Rpe65^-/- mice using photoentrainment of circadian rhythm

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Glutamate transport modulation: A possible role in retinal neuroprotection

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Related Research Outputs

Assessing the efficacy of gene therapy in Rpe65-/- mice using photoentrainment of circadian rhythm

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Assessing the efficacy of gene therapy in Rpe65^-/- mice using photoentrainment of circadian rhythm