Glutamate transport modulation: A possible role in retinal neuroprotection

Nigel L. Barnett, Kei Takamoto, Natalie D. Bull

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

1 Citation (Scopus)

Abstract

The regulation of extracellular glutamate levels in the retina, under physiological and pathophysiological conditions, is essential for the prevention of excitotoxic neurodegeneration. Glial and neuronal high-affinity glutamate transporters (excitatory amino acid transporters, EAATs) facilitate the rapid removal of glutamate from the extracellular space, thereby terminating the excitatory signal and reducing the possibility of excitotoxic neuronal damage. Failure or reversal of these transport systems leads to raised levels of extracellular glutamate and contributes to the development of excitotoxic retinal degeneration.
Original languageEnglish
Title of host publicationRetinal Degenerative Diseases
EditorsJoe G. Hollyfield, Robert E. Anderson, Matthew M. LaVail
Place of PublicationBoston
PublisherSpringer
Pages327-332
Number of pages6
ISBN (Electronic)978-0-387-32442-5
ISBN (Print)978-0-387-28464-4
DOIs
Publication statusPublished - 2006
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer
Volume572
ISSN (Print)0065-2598

Fingerprint

Glutamic Acid
Modulation
Amino Acid Transport Systems
Amino Acid Transport System X-AG
Retinal Degeneration
Excitatory Amino Acids
Extracellular Space
Neuroglia
Retina
Neuroprotection

Cite this

Barnett, N. L., Takamoto, K., & Bull, N. D. (2006). Glutamate transport modulation: A possible role in retinal neuroprotection. In J. G. Hollyfield, R. E. Anderson, & M. M. LaVail (Eds.), Retinal Degenerative Diseases (pp. 327-332). (Advances in Experimental Medicine and Biology; Vol. 572). Boston: Springer. https://doi.org/10.1007/0-387-32442-9_46
Barnett, Nigel L. ; Takamoto, Kei ; Bull, Natalie D. / Glutamate transport modulation : A possible role in retinal neuroprotection. Retinal Degenerative Diseases. editor / Joe G. Hollyfield ; Robert E. Anderson ; Matthew M. LaVail. Boston : Springer, 2006. pp. 327-332 (Advances in Experimental Medicine and Biology).
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Barnett, NL, Takamoto, K & Bull, ND 2006, Glutamate transport modulation: A possible role in retinal neuroprotection. in JG Hollyfield, RE Anderson & MM LaVail (eds), Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol. 572, Springer, Boston, pp. 327-332. https://doi.org/10.1007/0-387-32442-9_46

Glutamate transport modulation : A possible role in retinal neuroprotection. / Barnett, Nigel L.; Takamoto, Kei; Bull, Natalie D.

Retinal Degenerative Diseases. ed. / Joe G. Hollyfield; Robert E. Anderson; Matthew M. LaVail. Boston : Springer, 2006. p. 327-332 (Advances in Experimental Medicine and Biology; Vol. 572).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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Barnett NL, Takamoto K, Bull ND. Glutamate transport modulation: A possible role in retinal neuroprotection. In Hollyfield JG, Anderson RE, LaVail MM, editors, Retinal Degenerative Diseases. Boston: Springer. 2006. p. 327-332. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/0-387-32442-9_46