Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review

Wolfgang Marx, Karin Ried, Alexandra L. McCarthy, Luis Vitetta, Avni Sali, Daniel McKavanagh, Liz Isenring

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
89 Downloads (Pure)

Abstract

Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT 3, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalCritical Reviews in Food Science and Nutrition
Volume57
Issue number1
Early online date7 Apr 2015
DOIs
Publication statusPublished - 2 Jan 2017

Fingerprint

nausea
Chemotherapy
vomiting
Nausea
drug therapy
Vomiting
Ginger
ginger
Drug Therapy
antiemetics
Neurokinin-1 Receptors
gastrointestinal motility
gastric emptying
Rhizome
substance P
Gastrointestinal Motility
vasopressin
Antiemetics
cholinergic receptors
Gastric Emptying

Cite this

Marx, Wolfgang ; Ried, Karin ; McCarthy, Alexandra L. ; Vitetta, Luis ; Sali, Avni ; McKavanagh, Daniel ; Isenring, Liz. / Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review. In: Critical Reviews in Food Science and Nutrition. 2017 ; Vol. 57, No. 1. pp. 141-146.
@article{677ed0bbedbf4194aabe6636f9c92ad6,
title = "Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review",
abstract = "Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT 3, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.",
author = "Wolfgang Marx and Karin Ried and McCarthy, {Alexandra L.} and Luis Vitetta and Avni Sali and Daniel McKavanagh and Liz Isenring",
year = "2017",
month = "1",
day = "2",
doi = "10.1080/10408398.2013.865590",
language = "English",
volume = "57",
pages = "141--146",
journal = "CRC Critical Reviews in Food Science and Nutrition",
issn = "0007-9006",
publisher = "Taylor & Francis",
number = "1",

}

Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review. / Marx, Wolfgang; Ried, Karin; McCarthy, Alexandra L.; Vitetta, Luis; Sali, Avni; McKavanagh, Daniel; Isenring, Liz.

In: Critical Reviews in Food Science and Nutrition, Vol. 57, No. 1, 02.01.2017, p. 141-146.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review

AU - Marx, Wolfgang

AU - Ried, Karin

AU - McCarthy, Alexandra L.

AU - Vitetta, Luis

AU - Sali, Avni

AU - McKavanagh, Daniel

AU - Isenring, Liz

PY - 2017/1/2

Y1 - 2017/1/2

N2 - Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT 3, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.

AB - Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT 3, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.

UR - http://www.scopus.com/inward/record.url?scp=84991735389&partnerID=8YFLogxK

U2 - 10.1080/10408398.2013.865590

DO - 10.1080/10408398.2013.865590

M3 - Article

VL - 57

SP - 141

EP - 146

JO - CRC Critical Reviews in Food Science and Nutrition

JF - CRC Critical Reviews in Food Science and Nutrition

SN - 0007-9006

IS - 1

ER -