Genome-wide association study of prostate cancer-specific survival

Robert Szulkin; Robert Karlsson; Thomas Whitington; Markus Aly; Henrik Gronberg; Rosalind A. Eeles; Douglas F. Easton; Zsofia Kote-Jarai; Ali Amin Al Olama; Sara Benlloch; Australian Prostate Cancer BioResource; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; BPC3 Consortium; Jyotsna Batra

doi:10.1158/1055-9965.EPI-15-0543

Genome-wide association study of prostate cancer-specific survival

Robert Szulkin^*
, Robert Karlsson
, Thomas Whitington
, Markus Aly
, Henrik Gronberg
, Rosalind A. Eeles
, Douglas F. Easton
, Zsofia Kote-Jarai
, Ali Amin Al Olama
, Sara Benlloch
, Australian Prostate Cancer BioResource
, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
, BPC3 Consortium
, Jyotsna Batra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

Background:
Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.

Methods:
We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).

Results:
We observed no significant association between genetic variants and prostate cancer survival.

Conclusions:
Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

Original language	English
Pages (from-to)	1796-1800
Number of pages	5
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	24
Issue number	11
DOIs	https://doi.org/10.1158/1055-9965.EPI-15-0543
Publication status	Published - 1 Nov 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1158/1055-9965.EPI-15-0543Licence: Free to read

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Szulkin, R., Karlsson, R., Whitington, T., Aly, M., Gronberg, H., Eeles, R. A., Easton, D. F., Kote-Jarai, Z., Al Olama, A. A., Benlloch, S., Australian Prostate Cancer BioResource, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, BPC3 Consortium, & Batra, J. (2015). Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiology Biomarkers and Prevention, 24(11), 1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543

@article{bc40ef12a8404721a021a59797872996,

title = "Genome-wide association study of prostate cancer-specific survival",

abstract = "Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.",

author = "Robert Szulkin and Robert Karlsson and Thomas Whitington and Markus Aly and Henrik Gronberg and Eeles, \{Rosalind A.\} and Easton, \{Douglas F.\} and Zsofia Kote-Jarai and \{Al Olama\}, \{Ali Amin\} and Sara Benlloch and \{Australian Prostate Cancer BioResource\} and \{The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium\} and \{BPC3 Consortium\} and Kenneth Muir and Giles, \{Graham G.\} and Southey, \{Melissa C.\} and Fitzgerald, \{Liesel M.\} and Henderson, \{Brian E.\} and Schumacher, \{Fredrick R.\} and Haiman, \{Christopher A.\} and Csilla Sipeky and Tammela, \{Teuvol J.\} and Nordestgaard, \{B{\o}rge G.\} and Key, \{Timothy J.\} and Travis, \{Ruth C.\} and Neal, \{David E.\} and Donovan, \{Jenny L.\} and Hamdy, \{Freddie C.\} and Pharoah, \{Paul D.P.\} and Nora Pashayan and Khaw, \{Kay Tee\} and Stanford, \{Janet L.\} and Thibodeau, \{Stephen N.\} and McDonnell, \{Shannon K.\} and Schaid, \{Daniel J.\} and Christiane Maier and Walther Vogel and Manuel Luedeke and Kathleen Herkommer and Kibel, \{Adam S.\} and Cezary Cybulski and Jan Lubinski and Wojciech Kluzniak and Lisa Cannon-Albright and Hermann Brenner and Volker Herrmann and Bernd Holleczek and Park, \{Jong Y.\} and Sellers, \{Thomas A.\} and Lim, \{Hui Yi\} and Chavdar Slavov and Kaneva, \{Radka P.\} and Mitev, \{Vanio I.\} and Amanda Spurdle and Teixeira, \{Manuel R.\} and Paula Paulo and Sofia Maia and Hardev Pandha and Agnieszka Michael and Andrzej Kierzek and Jyotsna Batra and Clements, \{Judith A.\} and Demetrius Albanes and Andriole, \{Gerald L.\} and Berndt, \{Sonja I.\} and Stephen Chanock and Gapstur, \{Susan M.\} and Giovannucci, \{Edward L.\} and Hunter, \{David J.\} and Peter Kraft and \{Le Marchand\}, Loic and Jing Ma and Mondul, \{Alison M.\} and Penney, \{Kathryn L.\} and Stampfer, \{Meir J.\} and Stevens, \{Victoria L.\} and Weinstein, \{Stephanie J.\} and Antonia Trichopoulou and Bueno-De-mesquita, \{Bas H.\} and Anne Tj{\o}nneland and Cox, \{David G.\} and Lovise Maehle and Johanna Schleutker and Sara Lindstrom and Fredrik Wiklund",

note = "Publisher Copyright: {\textcopyright} 2015 AACR.",

year = "2015",

month = nov,

day = "1",

doi = "10.1158/1055-9965.EPI-15-0543",

language = "English",

volume = "24",

pages = "1796--1800",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "11",

}

Szulkin, R, Karlsson, R, Whitington, T, Aly, M, Gronberg, H, Eeles, RA, Easton, DF, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Australian Prostate Cancer BioResource, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, BPC3 Consortium & Batra, J 2015, 'Genome-wide association study of prostate cancer-specific survival', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 11, pp. 1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543

TY - JOUR

T1 - Genome-wide association study of prostate cancer-specific survival

AU - Szulkin, Robert

AU - Karlsson, Robert

AU - Whitington, Thomas

AU - Aly, Markus

AU - Gronberg, Henrik

AU - Eeles, Rosalind A.

AU - Easton, Douglas F.

AU - Kote-Jarai, Zsofia

AU - Al Olama, Ali Amin

AU - Benlloch, Sara

AU - Australian Prostate Cancer BioResource

AU - The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium

AU - BPC3 Consortium

AU - Muir, Kenneth

AU - Giles, Graham G.

AU - Southey, Melissa C.

AU - Fitzgerald, Liesel M.

AU - Henderson, Brian E.

AU - Schumacher, Fredrick R.

AU - Haiman, Christopher A.

AU - Sipeky, Csilla

AU - Tammela, Teuvol J.

AU - Nordestgaard, Børge G.

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Neal, David E.

AU - Donovan, Jenny L.

AU - Hamdy, Freddie C.

AU - Pharoah, Paul D.P.

AU - Pashayan, Nora

AU - Khaw, Kay Tee

AU - Stanford, Janet L.

AU - Thibodeau, Stephen N.

AU - McDonnell, Shannon K.

AU - Schaid, Daniel J.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Luedeke, Manuel

AU - Herkommer, Kathleen

AU - Kibel, Adam S.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Kluzniak, Wojciech

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Herrmann, Volker

AU - Holleczek, Bernd

AU - Park, Jong Y.

AU - Sellers, Thomas A.

AU - Lim, Hui Yi

AU - Slavov, Chavdar

AU - Kaneva, Radka P.

AU - Mitev, Vanio I.

AU - Spurdle, Amanda

AU - Teixeira, Manuel R.

AU - Paulo, Paula

AU - Maia, Sofia

AU - Pandha, Hardev

AU - Michael, Agnieszka

AU - Kierzek, Andrzej

AU - Batra, Jyotsna

AU - Clements, Judith A.

AU - Albanes, Demetrius

AU - Andriole, Gerald L.

AU - Berndt, Sonja I.

AU - Chanock, Stephen

AU - Gapstur, Susan M.

AU - Giovannucci, Edward L.

AU - Hunter, David J.

AU - Kraft, Peter

AU - Le Marchand, Loic

AU - Ma, Jing

AU - Mondul, Alison M.

AU - Penney, Kathryn L.

AU - Stampfer, Meir J.

AU - Stevens, Victoria L.

AU - Weinstein, Stephanie J.

AU - Trichopoulou, Antonia

AU - Bueno-De-mesquita, Bas H.

AU - Tjønneland, Anne

AU - Cox, David G.

AU - Maehle, Lovise

AU - Schleutker, Johanna

AU - Lindstrom, Sara

AU - Wiklund, Fredrik

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

AB - Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

UR - https://www.scopus.com/pages/publications/84946594253

U2 - 10.1158/1055-9965.EPI-15-0543

DO - 10.1158/1055-9965.EPI-15-0543

M3 - Article

C2 - 26307654

AN - SCOPUS:84946594253

SN - 1055-9965

VL - 24

SP - 1796

EP - 1800

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 11

ER -

Genome-wide association study of prostate cancer-specific survival

Abstract

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