Genome-wide association study of prostate cancer-specific survival

Robert Szulkin; Robert Karlsson; Thomas Whitington; Markus Aly; Henrik Gronberg; Rosalind A. Eeles; Douglas F. Easton; Zsofia Kote-Jarai; Ali Amin Al Olama; Sara Benlloch; Australian Prostate Cancer BioResource; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; BPC3 Consortium; Jyotsna Batra

doi:10.1158/1055-9965.EPI-15-0543

Genome-wide association study of prostate cancer-specific survival

Robert Szulkin^*, Robert Karlsson, Thomas Whitington, Markus Aly, Henrik Gronberg, Rosalind A. Eeles, Douglas F. Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Australian Prostate Cancer BioResource, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, BPC3 Consortium, Jyotsna Batra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Background:
Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.

Methods:
We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).

Results:
We observed no significant association between genetic variants and prostate cancer survival.

Conclusions:
Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

Original language	English
Pages (from-to)	1796-1800
Number of pages	5
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	24
Issue number	11
DOIs	https://doi.org/10.1158/1055-9965.EPI-15-0543
Publication status	Published - 1 Nov 2015
Externally published	Yes

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Szulkin, R., Karlsson, R., Whitington, T., Aly, M., Gronberg, H., Eeles, R. A., Easton, D. F., Kote-Jarai, Z., Al Olama, A. A., Benlloch, S., Australian Prostate Cancer BioResource, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, BPC3 Consortium, & Batra, J. (2015). Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiology Biomarkers and Prevention, 24(11), 1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543

@article{bc40ef12a8404721a021a59797872996,

title = "Genome-wide association study of prostate cancer-specific survival",

abstract = "Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.",

author = "Robert Szulkin and Robert Karlsson and Thomas Whitington and Markus Aly and Henrik Gronberg and Eeles, {Rosalind A.} and Easton, {Douglas F.} and Zsofia Kote-Jarai and {Al Olama}, {Ali Amin} and Sara Benlloch and {Australian Prostate Cancer BioResource} and {The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium} and {BPC3 Consortium} and Kenneth Muir and Giles, {Graham G.} and Southey, {Melissa C.} and Fitzgerald, {Liesel M.} and Henderson, {Brian E.} and Schumacher, {Fredrick R.} and Haiman, {Christopher A.} and Csilla Sipeky and Tammela, {Teuvol J.} and Nordestgaard, {B{\o}rge G.} and Key, {Timothy J.} and Travis, {Ruth C.} and Neal, {David E.} and Donovan, {Jenny L.} and Hamdy, {Freddie C.} and Pharoah, {Paul D.P.} and Nora Pashayan and Khaw, {Kay Tee} and Stanford, {Janet L.} and Thibodeau, {Stephen N.} and McDonnell, {Shannon K.} and Schaid, {Daniel J.} and Christiane Maier and Walther Vogel and Manuel Luedeke and Kathleen Herkommer and Kibel, {Adam S.} and Cezary Cybulski and Jan Lubinski and Wojciech Kluzniak and Lisa Cannon-Albright and Hermann Brenner and Volker Herrmann and Bernd Holleczek and Park, {Jong Y.} and Sellers, {Thomas A.} and Lim, {Hui Yi} and Chavdar Slavov and Kaneva, {Radka P.} and Mitev, {Vanio I.} and Amanda Spurdle and Teixeira, {Manuel R.} and Paula Paulo and Sofia Maia and Hardev Pandha and Agnieszka Michael and Andrzej Kierzek and Jyotsna Batra and Clements, {Judith A.} and Demetrius Albanes and Andriole, {Gerald L.} and Berndt, {Sonja I.} and Stephen Chanock and Gapstur, {Susan M.} and Giovannucci, {Edward L.} and Hunter, {David J.} and Peter Kraft and {Le Marchand}, Loic and Jing Ma and Mondul, {Alison M.} and Penney, {Kathryn L.} and Stampfer, {Meir J.} and Stevens, {Victoria L.} and Weinstein, {Stephanie J.} and Antonia Trichopoulou and Bueno-De-mesquita, {Bas H.} and Anne Tj{\o}nneland and Cox, {David G.} and Lovise Maehle and Johanna Schleutker and Sara Lindstrom and Fredrik Wiklund",

year = "2015",

month = nov,

day = "1",

doi = "10.1158/1055-9965.EPI-15-0543",

language = "English",

volume = "24",

pages = "1796--1800",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

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}

Szulkin, R, Karlsson, R, Whitington, T, Aly, M, Gronberg, H, Eeles, RA, Easton, DF, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Australian Prostate Cancer BioResource, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, BPC3 Consortium & Batra, J 2015, 'Genome-wide association study of prostate cancer-specific survival', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 11, pp. 1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543

TY - JOUR

T1 - Genome-wide association study of prostate cancer-specific survival

AU - Szulkin, Robert

AU - Karlsson, Robert

AU - Whitington, Thomas

AU - Aly, Markus

AU - Gronberg, Henrik

AU - Eeles, Rosalind A.

AU - Easton, Douglas F.

AU - Kote-Jarai, Zsofia

AU - Al Olama, Ali Amin

AU - Benlloch, Sara

AU - Australian Prostate Cancer BioResource

AU - The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium

AU - BPC3 Consortium

AU - Muir, Kenneth

AU - Giles, Graham G.

AU - Southey, Melissa C.

AU - Fitzgerald, Liesel M.

AU - Henderson, Brian E.

AU - Schumacher, Fredrick R.

AU - Haiman, Christopher A.

AU - Sipeky, Csilla

AU - Tammela, Teuvol J.

AU - Nordestgaard, Børge G.

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Neal, David E.

AU - Donovan, Jenny L.

AU - Hamdy, Freddie C.

AU - Pharoah, Paul D.P.

AU - Pashayan, Nora

AU - Khaw, Kay Tee

AU - Stanford, Janet L.

AU - Thibodeau, Stephen N.

AU - McDonnell, Shannon K.

AU - Schaid, Daniel J.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Luedeke, Manuel

AU - Herkommer, Kathleen

AU - Kibel, Adam S.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Kluzniak, Wojciech

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Herrmann, Volker

AU - Holleczek, Bernd

AU - Park, Jong Y.

AU - Sellers, Thomas A.

AU - Lim, Hui Yi

AU - Slavov, Chavdar

AU - Kaneva, Radka P.

AU - Mitev, Vanio I.

AU - Spurdle, Amanda

AU - Teixeira, Manuel R.

AU - Paulo, Paula

AU - Maia, Sofia

AU - Pandha, Hardev

AU - Michael, Agnieszka

AU - Kierzek, Andrzej

AU - Batra, Jyotsna

AU - Clements, Judith A.

AU - Albanes, Demetrius

AU - Andriole, Gerald L.

AU - Berndt, Sonja I.

AU - Chanock, Stephen

AU - Gapstur, Susan M.

AU - Giovannucci, Edward L.

AU - Hunter, David J.

AU - Kraft, Peter

AU - Le Marchand, Loic

AU - Ma, Jing

AU - Mondul, Alison M.

AU - Penney, Kathryn L.

AU - Stampfer, Meir J.

AU - Stevens, Victoria L.

AU - Weinstein, Stephanie J.

AU - Trichopoulou, Antonia

AU - Bueno-De-mesquita, Bas H.

AU - Tjønneland, Anne

AU - Cox, David G.

AU - Maehle, Lovise

AU - Schleutker, Johanna

AU - Lindstrom, Sara

AU - Wiklund, Fredrik

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

AB - Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

UR - http://www.scopus.com/inward/record.url?scp=84946594253&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-15-0543

DO - 10.1158/1055-9965.EPI-15-0543

M3 - Article

C2 - 26307654

AN - SCOPUS:84946594253

SN - 1055-9965

VL - 24

SP - 1796

EP - 1800

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 11

ER -

Genome-wide association study of prostate cancer-specific survival

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