TY - JOUR
T1 - Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
AU - Vijayakrishnan, Jayaram
AU - Studd, James
AU - Broderick, Peter
AU - Kinnersley, Ben
AU - Holroyd, Amy
AU - Law, Philip J.
AU - Kumar, Rajiv
AU - Allan, James M.
AU - Harrison, Christine J.
AU - Moorman, Anthony V.
AU - The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
AU - Vora, Ajay
AU - Roman, Eve
AU - Rachakonda, Sivaramakrishna
AU - Kinsey, Sally E.
AU - Sheridan, Eamonn
AU - Thompson, Pamela D.
AU - Irving, Julie A.
AU - Koehler, Rolf
AU - Hoffmann, Per
AU - Nöthen, Markus M.
AU - Heilmann-Heimbach, Stefanie
AU - Jöckel, Karl Heinz
AU - Easton, Douglas F.
AU - Pharaoh, Paul D.P.
AU - Dunning, Alison M.
AU - Peto, Julian
AU - Canzian, Frederico
AU - Swerdlow, Anthony
AU - Eeles, Rosalind A.
AU - Kote-Jarai, ZSofia
AU - Muir, Kenneth
AU - Pashayan, Nora
AU - Greaves, Mel
AU - Zimmerman, Martin
AU - Bartram, Claus R.
AU - Schrappe, Martin
AU - Stanulla, Martin
AU - Hemminki, Kari
AU - Houlston, Richard S.
AU - Henderson, Brian E.
AU - Haiman, Christopher A.
AU - Benlloch, Sara
AU - Schumacher, Fredrick R.
AU - Olama, Ali Amin Al
AU - Berndt, Sonja I.
AU - Conti, David V.
AU - Wiklund, Fredrik
AU - Chanock, Stephen
AU - Stevens, Victoria L.
AU - Tangen, Catherine M.
AU - Batra, Jyotsna
AU - Clements, Judith
AU - Gronberg, Henrik
AU - Schleutker, Johanna
AU - Albanes, Demetrius
AU - Weinstein, Stephanie
AU - Wolk, Alicja
AU - West, Catharine
AU - Mucci, Lorelei
AU - Cancel-Tassin, Géraldine
AU - Koutros, Stella
AU - Sorensen, Karina Dalsgaard
AU - Maehle, Lovise
AU - Neal, David E.
AU - Travis, Ruth C.
AU - Hamilton, Robert J.
AU - Ingles, Sue Ann
AU - Rosenstein, Barry
AU - Lu, Yong Jie
AU - Giles, Graham G.
AU - Kibel, Adam S.
AU - Vega, Ana
AU - Kogevinas, Manolis
AU - Penney, Kathryn L.
AU - Park, Jong Y.
AU - Stanford, Janet L.
AU - Cybulski, Cezary
AU - Nordestgaard, Børge G.
AU - Brenner, Hermann
AU - Maier, Christiane
AU - Kim, Jeri
AU - John, Esther M.
AU - Teixeira, Manuel R.
AU - Neuhausen, Susan L.
AU - De Ruyck, Kim
AU - Razack, Azad
AU - Newcomb, Lisa F.
AU - Lessel, Davor
AU - Kaneva, Radka
AU - Usmani, Nawaid
AU - Claessens, Frank
AU - Townsend, Paul A.
AU - Dominguez, Manuela Gago
AU - Roobol, Monique J.
AU - Menegaux, Florence
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
AB - Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
UR - https://www.scopus.com/pages/publications/85045221334
U2 - 10.1038/s41467-018-03178-z
DO - 10.1038/s41467-018-03178-z
M3 - Article
C2 - 29632299
AN - SCOPUS:85045221334
SN - 2041-1723
VL - 9
SP - 1
EP - 9
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 1340
ER -