Genetics and cardiovascular disease: Design and development of a DNA biobank

Satyajit Rohan Jayasinghe, Akshay Mishra, Angela Van Daal, Edmond Kwan

Research output: Contribution to journalReview articleResearchpeer-review

8 Citations (Scopus)

Abstract

Coronary artery disease (CAD) is a complex disease with environmental and genetic determinants. Many other cardiovascular (CV) conditions also have a genetic basis. A positive family history of CV disease in first-degree relatives is a strong independent risk factor for CAD as well as several other cardiac disorders. This genetic susceptibility to CV diseases will be understood more clearly when combined with genomics, proteomics and genotyping. The Department of Cardiology at Gold Coast Hospital (Queensland, Australia) with the Faculty of Health, Science and Medicine at Bond University (Queensland, Australia) established the Gold Coast Cardiovascular DNA bank in 2006. The dataset on each individual volunteer includes coronary angiograms, clinical information (including a coronary risk factor profile), biochemical (including cardiac biomarkers) and hematological parameters, and electrocardiograms and echocardiograms. The establishment of the DNA biobank was associated with several key challenges, both technical and logistic. Given the comprehensive nature of the information gathered, the present study has the added potential of identifying genes associated with nonischemic cardiomyopathies, valvular heart disease, congenital heart diseases and other cardiomyopathies. Pooling data from results obtained here with multiple existing DNA biobanks and registries will help in finding answers to the genetic conundrum in CV diseases. The present DNA biobank will serve as a resource well into the future as the technology and science of medical genetics evolve. The most frequent pathology encountered in the biobank is CAD. The significance of the familial occurrence of CAD has been the focus of research for at least 50 years, with a positive family history of CV disease emerging as an independent predictor of risk in the development of CAD. By applying the knowledge learned from studies on CV genetics together with the data from the DNA biobank, scientists may be able to effectively prevent and treat CV diseases in the future.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalExperimental and Clinical Cardiology
Volume14
Issue number3
Publication statusPublished - Sep 2009

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Inborn Genetic Diseases
Coronary Artery Disease
Cardiovascular Diseases
DNA
Ghana
Queensland
Cardiomyopathies
Medical Genetics
Genetic Predisposition to Disease
Genomics
Cardiology
Proteomics
Registries
Meta-Analysis
Volunteers
Heart Diseases
Angiography
Electrocardiography
Biomarkers
Medicine

Cite this

Jayasinghe, S. R., Mishra, A., Van Daal, A., & Kwan, E. (2009). Genetics and cardiovascular disease: Design and development of a DNA biobank. Experimental and Clinical Cardiology, 14(3), 33-37.
Jayasinghe, Satyajit Rohan ; Mishra, Akshay ; Van Daal, Angela ; Kwan, Edmond. / Genetics and cardiovascular disease : Design and development of a DNA biobank. In: Experimental and Clinical Cardiology. 2009 ; Vol. 14, No. 3. pp. 33-37.
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Jayasinghe, SR, Mishra, A, Van Daal, A & Kwan, E 2009, 'Genetics and cardiovascular disease: Design and development of a DNA biobank' Experimental and Clinical Cardiology, vol. 14, no. 3, pp. 33-37.

Genetics and cardiovascular disease : Design and development of a DNA biobank. / Jayasinghe, Satyajit Rohan; Mishra, Akshay; Van Daal, Angela; Kwan, Edmond.

In: Experimental and Clinical Cardiology, Vol. 14, No. 3, 09.2009, p. 33-37.

Research output: Contribution to journalReview articleResearchpeer-review

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T1 - Genetics and cardiovascular disease

T2 - Design and development of a DNA biobank

AU - Jayasinghe, Satyajit Rohan

AU - Mishra, Akshay

AU - Van Daal, Angela

AU - Kwan, Edmond

PY - 2009/9

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N2 - Coronary artery disease (CAD) is a complex disease with environmental and genetic determinants. Many other cardiovascular (CV) conditions also have a genetic basis. A positive family history of CV disease in first-degree relatives is a strong independent risk factor for CAD as well as several other cardiac disorders. This genetic susceptibility to CV diseases will be understood more clearly when combined with genomics, proteomics and genotyping. The Department of Cardiology at Gold Coast Hospital (Queensland, Australia) with the Faculty of Health, Science and Medicine at Bond University (Queensland, Australia) established the Gold Coast Cardiovascular DNA bank in 2006. The dataset on each individual volunteer includes coronary angiograms, clinical information (including a coronary risk factor profile), biochemical (including cardiac biomarkers) and hematological parameters, and electrocardiograms and echocardiograms. The establishment of the DNA biobank was associated with several key challenges, both technical and logistic. Given the comprehensive nature of the information gathered, the present study has the added potential of identifying genes associated with nonischemic cardiomyopathies, valvular heart disease, congenital heart diseases and other cardiomyopathies. Pooling data from results obtained here with multiple existing DNA biobanks and registries will help in finding answers to the genetic conundrum in CV diseases. The present DNA biobank will serve as a resource well into the future as the technology and science of medical genetics evolve. The most frequent pathology encountered in the biobank is CAD. The significance of the familial occurrence of CAD has been the focus of research for at least 50 years, with a positive family history of CV disease emerging as an independent predictor of risk in the development of CAD. By applying the knowledge learned from studies on CV genetics together with the data from the DNA biobank, scientists may be able to effectively prevent and treat CV diseases in the future.

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M3 - Review article

VL - 14

SP - 33

EP - 37

JO - Experimental and Clinical Cardiology

JF - Experimental and Clinical Cardiology

SN - 1205-6626

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