TY - JOUR
T1 - Genetic contribution of chemokine receptor 2 (CCR2) polymorphisms towards increased serum total IgE levels in Indian asthmatics
AU - Batra, Jyotsna
AU - Ghosh, Balaram
PY - 2009/9/1
Y1 - 2009/9/1
N2 - The chemokine (C-C motif) receptors (CCR) 2 and 5 are members of a large family of G protein-coupled receptors, playing important roles in asthma pathogenesis. Using standard sequencing techniques, a total of 15 single nucleotide and 8 insertion/deletion polymorphisms (DIPs) (5 novels) were identified in and around these two genes. None of the studied polymorphisms (N = 7, selected on the basis on linkage disequilibrium) was associated with asthma in a case (N = 315) - control (N = 337) study and showed no evidence for non-random transmission to individuals with asthma/atopy in Indian pedigrees (n = 235). However, multilocus haplotype analysis based on simulations yielded a P = 0.00005 in the case-control study and a P = 0.03 for the family-based association studies. Furthermore, rs3918356 and rs743660 polymorphisms in CCR2 were found to be associated with total serum IgE levels in both the study designs. Thus, our study supports a significant role for chemokine receptor polymorphisms in genetic susceptibility to asthma. © 2009 Elsevier Inc. All rights reserved.
AB - The chemokine (C-C motif) receptors (CCR) 2 and 5 are members of a large family of G protein-coupled receptors, playing important roles in asthma pathogenesis. Using standard sequencing techniques, a total of 15 single nucleotide and 8 insertion/deletion polymorphisms (DIPs) (5 novels) were identified in and around these two genes. None of the studied polymorphisms (N = 7, selected on the basis on linkage disequilibrium) was associated with asthma in a case (N = 315) - control (N = 337) study and showed no evidence for non-random transmission to individuals with asthma/atopy in Indian pedigrees (n = 235). However, multilocus haplotype analysis based on simulations yielded a P = 0.00005 in the case-control study and a P = 0.03 for the family-based association studies. Furthermore, rs3918356 and rs743660 polymorphisms in CCR2 were found to be associated with total serum IgE levels in both the study designs. Thus, our study supports a significant role for chemokine receptor polymorphisms in genetic susceptibility to asthma. © 2009 Elsevier Inc. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=68549117001&partnerID=8YFLogxK
U2 - 10.1016/j.ygeno.2009.05.013
DO - 10.1016/j.ygeno.2009.05.013
M3 - Article
C2 - 19520154
AN - SCOPUS:68549117001
SN - 0888-7543
VL - 94
SP - 161
EP - 168
JO - Genomics
JF - Genomics
IS - 3
ER -