General functioning predicts reward and punishment learning in schizophrenia

Zsuzsanna Somlai, Ahmed A. Moustafa*, Szabolcs Kéri, Catherine E. Myers, Mark A. Gluck

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Previous studies investigating feedback-driven reinforcement learning in patients with schizophrenia have provided mixed results. In this study, we explored the clinical predictors of reward and punishment learning using a probabilistic classification learning task. Patients with schizophrenia (n = 40) performed similarly to healthy controls (n = 30) on the classification learning task. However, more severe negative and general symptoms were associated with lower reward-learning performance, whereas poorer general psychosocial functioning was correlated with both lower reward- and punishment-learning performances. Multiple linear regression analyses indicated that general psychosocial functioning was the only significant predictor of reinforcement learning performance when education, antipsychotic dose, and positive, negative and general symptoms were included in the analysis. These results suggest a close relationship between reinforcement learning and general psychosocial functioning in schizophrenia.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalSchizophrenia Research
Volume127
Issue number1-3
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

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