From physiome to pathome: A systems biology model of major depressive disorder and the psycho-immune-neuroendocrine network

N. J.C. Stapelberg*, D. L. Neumann, D. H.K. Shum, H. McConnell, I. Hamilton-Craig

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

This article introduces a systems biology model of the psycho-immune-neuroendocrine (PINE) network. It provides a comprehensive synthesis of the network of biological mechanisms which link major depressive disorder (MDD) with several diseases including hypertension, atherosclerosis, coronary heart disease (CHD), cerebrovascular accident (CVA) and type 2 diabetes. The first part of this article provides an overview of concepts such as the PINE physiome and pathome, as well as the application of a systems biology framework to explain the significant reciprocal associations of MDD with the above named medical illnesses. The second part describes the normal physiological pathways of immune mechanisms, the hypothalamic-pituitary-adrenal (HPA) axis, autonomic pathways and central nervous system function, which form the PINE physiome. The third section describes how homeostasis of the PINE physiome is disrupted by chronic stress, on a background of genetic and developmental diathesis factors, resulting in a network of pathophysiological pathways called the PINE pathome. MDD, CHD, type 2 diabetes, CVA, hypertension and atherosclerosis can act to maintain the PINE network in a stable pathological state. This article presents comprehensive topographical maps of both the PINE physiome and the PINE pathome. Implications of the model and the importance of adopting a systems approach to understanding the relationship between these diseases is discussed in the last section, including the possibility of novel treatments for MDD and areas of future research.

Original languageEnglish
Pages (from-to)32-62
Number of pages31
JournalCurrent Psychiatry Reviews
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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Systems Biology
Major Depressive Disorder
Type 2 Diabetes Mellitus
Coronary Disease
Atherosclerosis
Stroke
Hypertension
Autonomic Pathways
Autonomic Nervous System
Disease Susceptibility
Systems Analysis
Homeostasis
Central Nervous System
Patient-Specific Modeling

Cite this

Stapelberg, N. J.C. ; Neumann, D. L. ; Shum, D. H.K. ; McConnell, H. ; Hamilton-Craig, I. / From physiome to pathome: A systems biology model of major depressive disorder and the psycho-immune-neuroendocrine network. In: Current Psychiatry Reviews. 2015 ; Vol. 11, No. 1. pp. 32-62.
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From physiome to pathome: A systems biology model of major depressive disorder and the psycho-immune-neuroendocrine network. / Stapelberg, N. J.C.; Neumann, D. L.; Shum, D. H.K.; McConnell, H.; Hamilton-Craig, I.

In: Current Psychiatry Reviews, Vol. 11, No. 1, 01.01.2015, p. 32-62.

Research output: Contribution to journalArticleResearchpeer-review

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