From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression

N J C Stapelberg, R Pratt, D L Neumann, D H K Shum, S Brandis, V Muthukkumarasamy, B Stantic, M Blumenstein, J P Headrick

Research output: Contribution to journalReview articleResearchpeer-review

7 Citations (Scopus)
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Abstract

BACKGROUND: 

Biological pathways underlying major depressive disorder (MDD) can be viewed as systems biology networks. The psycho-immune-neuroendocrine (PINE) network comprises central nervous, immune, endocrine and autonomic systems, integrating biological mechanisms of MDD. Such networks exhibit recurrent motifs with specific functions, including positive and negative feedback loops, and are subject to critical transitions, influenced by feedback loop transitions (FLTs).

AIMS: 

We aim to identify critical feedback loops and their FLTs, as well sentinel network nodes (SNNs), key network nodes that drive FLTs, within the PINE network. Examples of biomarkers are provided which may reflect early warning signs of impending critical transition to MDD.

RESULTS: 

Disruption of homeostatic feedback loops reflects the physiological transition to MDD. Putative FLTs are identified within hypothalamic-pituitary-adrenal (HPA) and sympathetic-parasympathetic axes, the kynurenine pathway, gut function and dysbiosis.

CONCLUSIONS: 

Progression from health to disease is driven by FLTs in the PINE network, which is likely to undergo changes characteristic of system instability. Biomarkers of system instability may effectively predict the critical transition to MDD.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalNeuroscience and Biobehavioral Reviews
Volume90
Early online date8 Mar 2018
DOIs
Publication statusPublished - Jul 2018

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Health Transition
Biomarkers
Depression
Major Depressive Disorder
Dysbiosis
Kynurenine
Endocrine System
Systems Biology
Central Nervous System

Cite this

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title = "From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression",
abstract = "BACKGROUND: Biological pathways underlying major depressive disorder (MDD) can be viewed as systems biology networks. The psycho-immune-neuroendocrine (PINE) network comprises central nervous, immune, endocrine and autonomic systems, integrating biological mechanisms of MDD. Such networks exhibit recurrent motifs with specific functions, including positive and negative feedback loops, and are subject to critical transitions, influenced by feedback loop transitions (FLTs).AIMS: We aim to identify critical feedback loops and their FLTs, as well sentinel network nodes (SNNs), key network nodes that drive FLTs, within the PINE network. Examples of biomarkers are provided which may reflect early warning signs of impending critical transition to MDD.RESULTS: Disruption of homeostatic feedback loops reflects the physiological transition to MDD. Putative FLTs are identified within hypothalamic-pituitary-adrenal (HPA) and sympathetic-parasympathetic axes, the kynurenine pathway, gut function and dysbiosis.CONCLUSIONS: Progression from health to disease is driven by FLTs in the PINE network, which is likely to undergo changes characteristic of system instability. Biomarkers of system instability may effectively predict the critical transition to MDD.",
author = "Stapelberg, {N J C} and R Pratt and Neumann, {D L} and Shum, {D H K} and S Brandis and V Muthukkumarasamy and B Stantic and M Blumenstein and Headrick, {J P}",
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From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network : Detecting the critical transition from health to major depression. / Stapelberg, N J C; Pratt, R; Neumann, D L; Shum, D H K; Brandis, S; Muthukkumarasamy, V; Stantic, B; Blumenstein, M; Headrick, J P.

In: Neuroscience and Biobehavioral Reviews, Vol. 90, 07.2018, p. 1-15.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network

T2 - Detecting the critical transition from health to major depression

AU - Stapelberg, N J C

AU - Pratt, R

AU - Neumann, D L

AU - Shum, D H K

AU - Brandis, S

AU - Muthukkumarasamy, V

AU - Stantic, B

AU - Blumenstein, M

AU - Headrick, J P

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/7

Y1 - 2018/7

N2 - BACKGROUND: Biological pathways underlying major depressive disorder (MDD) can be viewed as systems biology networks. The psycho-immune-neuroendocrine (PINE) network comprises central nervous, immune, endocrine and autonomic systems, integrating biological mechanisms of MDD. Such networks exhibit recurrent motifs with specific functions, including positive and negative feedback loops, and are subject to critical transitions, influenced by feedback loop transitions (FLTs).AIMS: We aim to identify critical feedback loops and their FLTs, as well sentinel network nodes (SNNs), key network nodes that drive FLTs, within the PINE network. Examples of biomarkers are provided which may reflect early warning signs of impending critical transition to MDD.RESULTS: Disruption of homeostatic feedback loops reflects the physiological transition to MDD. Putative FLTs are identified within hypothalamic-pituitary-adrenal (HPA) and sympathetic-parasympathetic axes, the kynurenine pathway, gut function and dysbiosis.CONCLUSIONS: Progression from health to disease is driven by FLTs in the PINE network, which is likely to undergo changes characteristic of system instability. Biomarkers of system instability may effectively predict the critical transition to MDD.

AB - BACKGROUND: Biological pathways underlying major depressive disorder (MDD) can be viewed as systems biology networks. The psycho-immune-neuroendocrine (PINE) network comprises central nervous, immune, endocrine and autonomic systems, integrating biological mechanisms of MDD. Such networks exhibit recurrent motifs with specific functions, including positive and negative feedback loops, and are subject to critical transitions, influenced by feedback loop transitions (FLTs).AIMS: We aim to identify critical feedback loops and their FLTs, as well sentinel network nodes (SNNs), key network nodes that drive FLTs, within the PINE network. Examples of biomarkers are provided which may reflect early warning signs of impending critical transition to MDD.RESULTS: Disruption of homeostatic feedback loops reflects the physiological transition to MDD. Putative FLTs are identified within hypothalamic-pituitary-adrenal (HPA) and sympathetic-parasympathetic axes, the kynurenine pathway, gut function and dysbiosis.CONCLUSIONS: Progression from health to disease is driven by FLTs in the PINE network, which is likely to undergo changes characteristic of system instability. Biomarkers of system instability may effectively predict the critical transition to MDD.

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JF - Biobehavioral Reviews

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